Wilms tumour is a paediatric malignancy with features of halted kidney development. Here, we demonstrate that the Iroquois homeobox genes IRX3 and IRX5 are essential for mammalian nephrogenesis and govern the differentiation of Wilms tumour. Knock-out Irx3−/Irx5− mice showed a strongly reduced embryonic nephron formation. In human foetal kidney and Wilms tumour, IRX5 expression was already activat

Improving the lung function after experimental allergen challenge by blocking of mast cell (MC) mediators and the capability of MC mediators (including histamine, prostaglandin (PG) D2, and leukotriene (LT) C4) in induction of mucosal edema, bronchoconstriction, and mucus secretion provide evidence that MCs play a key role in pathophysiology of asthma. In asthma, the number of MCs increases in the

Hyperlocal media has repeatedly been framed as a potential saviour of local journalism, but the democratic and civic role that often is ascribed to hyperlocals is not obvious or uncomplicated. The hyperlocals’ vulnerable economic situation makes them dependent on free content, for example material produced by local councils or organizations. This paper investigates the role of hyperlocal media ent

Background: With improving survival in ovarian cancer, second primary cancers (SPCs) and their etiological foundations are becoming an issue. The ways in which family history may influence the occurrence of SPCs and the related mortality are not well known. Methods: Based on the Swedish Family-Cancer Database, we identified 11,300 ovarian cancer patients and followed them for diagnoses of SPCs unt

While a standard part of twin modeling, the magnitude of shared environment (c2) is rarely examined by comparing estimates obtained using other methods. To clarify these effects on familial resemblance, we estimated c2 for 20 diverse phenotypes in: (i) monozygotic and dizygotic twins, (ii) all step-siblings, and (iii) reared together and apart half-siblings, ascertained from the Swedish general po

Background: Familial clustering of upper gastrointestinal (UGI) cancers and the significance of family history has been addressed previously. We aimed to elucidate the familial risk based on the specified tumor location and histology. Method: In the Swedish Family-Cancer Database, we determined the familial risk of UGI cancer patients diagnosed (1958–2015) with esophageal and gastric cancer by tum

During recent years there has been an increasing demand for better operation of wastewater treatment plants in order to guarantee satisfactory effluent quality at minimal cost. The renewed interest in instrumentation and control comes after a period of huge investments in sewer networks and treatment plants. Several factors have contributed to the potential for better operation and control, such a

Problemet med förfalskade läkemedel är stort globalt. Patienter med svårbedömdasymtom kan ha biverkningar av sådana. Läkare behöver vara mer medvetna om förekomsten av förfalskade läkemedel, och veta hur de ska handskas med problemet.

A comparison of social impact categorisation in strategic planning across European Union Member States shows that Sweden neither categorises nor breaks down categories of social impact in areas such as transport infrastructure development. This is surprising because Sweden is known as a country concerned about social issues and having a high standard of welfare. This article accordingly studies ho

Buried waste in old landfills is an increasing problem as cities expand and grow into areas with former waste deposits. In order to be able to manage and as far as possible reclaim land in such areas, better tools are needed for mapping and characterisation of buried waste and contaminated land. Other problems associated with landfills are leachate water and methane emissions. In the results prese

Substandard and falsified (SF) medical products are a major danger to public health. They affect every region of the world, and have been identified in all major therapeutic categories. Studies from medicine, pharmacology, law and public health dominate this research area with a focus on the supply side. However, the spread of SF medical products cannot be fully understood without information abou

Most pastoralists’ in Sub Saharan Africa (SSA) are adversely affected by climate-change related shocks such as droughts and livestock diseases. These shocks lead to deterioration of livestock quality and even mass death of herds. This leaves pastoralists vulnerable as they derive most of their food and income needs from livestock, necessitating emergency disaster response and the need to build the

The general aim of the research programme SPEAK (Sustainable Planning andEnvironmental Assessment Knowledge, www.speakproject.se) was to generateknowledge on, and to strengthen the role of strategic environmental assessment(SEA) in planning as a measure to attain the environmental quality objectives andto promote sustainable development. The SPEAK programme had atransdisciplinary point of departur