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Interaction of haemin with albumin-based macroporous cryogel : Adsorption isotherm and fluorescence quenching studies

Albumin-based cryogels for capturing haemin were synthesised by crosslinking different biomolecules, bovine serum albumin (BSA) and ovalbumin (OVA). The impact of the protein and coupling agent concentrations on cryogel’s mechanical properties, swelling ratios and polymerisation yields, as well as autoclaving as a post-treatment on the cryogel, were studied. We found that BSA (50 mg/ml) and the cr

Playing in the moral imaginary : Interacting with monsters and animals in The Witcher 3: The Wild Hunt

This paper explores the dark gothic fantasy world of The Witcher 3: The Wild Hunt, an open-world video game from 2015. Using The Witcher 3 as a case study, the paper examines the moral dimensions of player interaction within the game beyond dialogue trees and NPC interaction. By investigating how the player is presented with monsters and animals within the game world, the paper makes an argument f

Diet and bowel function in children with Hirschsprung’s disease : development and content validation of a patient-reported questionnaire

Background: Although dietary adjustments are recommended frequently for bowel symptoms, evidence of diet’s impact on bowel function is lacking. The aim was to develop a patient-reported outcome instrument, for children with and without Hirschsprung’s disease (HD), to explore experiences of dietary effects on bowel function. Methods: Children with and without HD and their parents participated. Ques

Temperature-driven transition into vortex clusters in low-kappa intertype superconductors

In the vicinity of the type-I/type-II crossover in conventional superconductors, vortices exhibit a nonmonotonic interaction, which leads to exotic vortex matter states. We perform molecular dynamics simulations on a model superconductor in the intertype regime. In a field cooled approach, we examine the transition of a homogeneous vortex lattice (VL) into a structure consisting of VL domains and

Implementation of the measure of case discussion complexity to guide selection of prostate cancer patients for multidisciplinary team meetings

Background: Multidisciplinary team meetings (MDTMs) provide an integrated team approach to ensure individualized and evidence-based treatment recommendations and best expert advice in cancer care. A growing number of patients and more complex treatment options challenge MDTM resources and evoke needs for case prioritization. In this process, decision aids could provide streamlining and standardize

A reality check on the GARCH-MIDAS volatility models

We employ a battery of model evaluation tests for a broad set of GARCH-MIDAS models and account for data snooping bias. We document that inferences based on standard tests for GM variance components can be misleading. Our data mining free results show that the gain of macro-variables in forecasting total (long-run) variance by GM models is overstated (understated). Estimation of different componen

Burning a holy book: the dilemma of free speech

In recent weeks, Sweden has experienced several Quran-burning incidents. These can reinforce anti-religious discourse and politicised campaigns against religious minorities. They can also put Swedish multicultural harmony at risk. Azher Hameed Qamar argues that we must interpret the laws permitting Quran-burnings as being in the best interest of the people

Regulation of human oocyte maturation in vivo during the final maturation of follicles

STUDY QUESTION: Which substances and signal transduction pathways are potentially active downstream to the effect of FSH and LH in the regulation of human oocyte maturation in vivo? SUMMARY ANSWER: The regulation of human oocyte maturation appears to be a multifactorial process in which several different signal transduction pathways are active. WHAT IS KNOWN ALREADY: Many studies in animal species

Institutionalised Dreams : The Art of Managing Foreign Aid

Using examples from Poland, Elżbieta Drążkiewicz explores the question of why states become donors and individuals decide to share their wealth with others through foreign aid. She comes to the conclusion that the concept of foreign aid requires the establishment of a specific moral economy which links national ideologies and local cultures of charitable giving with broader ideas about the global

Synergistic Fluorine⋅⋅⋅Sulfur Intra- and Intermolecular Interactions on Dopant-Free Hole Transport Material for Efficient and Stable Inverted Perovskite Solar Cells

Designing dopant-free small-molecule hole transport materials (HTMs) with self-assembly behavior via noncovalent interactions is considered as one effective strategy to achieve high-performance inverted perovskite solar cells (PSCs). Herein, two donor-π bridge-donor (D–π–D) HTMs are presented, TPASF and TPAOF, containing 3,6-dimethoxythieno[3,2-b]thiophene as a core part with 3-fluoro-N,N-bis(4-(m

Recombinant factor IX Fc prophylaxis reduces pain and increases levels of physical activity, with sustained, long-term improvements in patients with hemophilia B : post hoc analysis of phase III trials using patient-reported outcomes

Background: Pain is a common symptom of hemophilia that may adversely affect patients’ quality of life (QoL). Previous post hoc analyses of prophylaxis with recombinant factor IX Fc fusion protein (rFIXFc) have been published for adults and adolescents, demonstrating improvements in health-related QoL (HRQoL) when assessed by the haemophilia-specific QoL (HaemAQoL) questionnaire. Objective: To des

Vulnerable Victims or Agents of Change? A qualitative content analysis on the representation of women in Nepal's National Adaptation Plan

Climate adaptation policies in Nepal have previously depicted women as vulnerable victims. Policy-makers have described women as a weak and voiceless group that needs “saving” in environmental politics. Several studies have emphasized that these simplistic representations perpetuate gender stereotypes and omit proactive roles in climate action. Recent developments in feminist academia recognize th

Nairobi on Board: Skateboarders' Sensory Experiences of Community, Body, and Space

In this paper, I argue skateboarding to be a ritualizing performance that acts as a catalyst for transformative energies and heightened emotional states. Aided by the sensory experience of riding a board, powerful feelings of connectedness and unity arise amongst those who practice skateboarding, so intense that they transgress day-to-day social boundaries and temporarily overcome the socioeconomi

Decision Tree Learning Algorithm for Classifying Knee Injury Status Using Return-to-Activity Criteria

Anterior cruciate ligament (ACL) injury rates in female adolescents are increasing. Irrespective of treatment options, approximately 1/3 will suffer secondary ACL injuries following their return to activity (RTA). Despite this, there are no evidence-informed RTA guidelines to aid clinicians in deciding when this should occur. The first step towards these guidelines is to identify relevant and feas

Wafer-Scale Synthesis of Semiconducting SnO Monolayers from Interfacial Oxide Layers of Metallic Liquid Tin

Atomically thin semiconductors are one of the fastest growing categories in materials science due to their promise to enable high-performance electronic and optical devices. Furthermore, a host of intriguing phenomena have been reported to occur when a semiconductor is confined within two dimensions. However, the synthesis of large area atomically thin materials remains as a significant technologi

The 'lost generation' in adult psychiatry : psychiatric, neurodevelopmental and sociodemographic characteristics of psychiatric patients with autism unrecognised in childhood

Background Patients with 'underlying' autism spectrum disorder (ASD) constitute a significant minority in adult out-patient psychiatry. Diagnoses of previously unrecognised ASD are increasing in adults. Characteristics of patients with autism within adult out-patient psychiatry have not been sufficiently explored, and there have not been any systematic comparisons of characteristics between patien

Jane Austen’s Exploration of Romanticism: Teaching “older” Literature Through Northanger Abbey in the Swedish Upper-Secondary English Classroom

This paper argues that Jane Austen’s Northanger Abbey is a valuable pedagogical resource that can address the Swedish National Agency for Education’s mandate on the coverage of “older” literature in Swedish EFL courses at upper secondary school in a flexible and thorough way. Presupposing that the novel comprises various literary genres and forms, the paper provides a close reading through a propo