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Cytology is central in the diagnosis of malignancy in effusions. Ancillary techniques, mainly immunocytochemistry, have considerably improved the sensitivity but some 10% of all cases remain equivocal and require the addition of new diagnostic modalities. We have previously shown that strong nuclear telomerase activity determined with Telomere Repeat Amplification Protocol (TRAP) in situ is specif

Simvastatin is widely used to lower cholesterol levels in patients with cardiovascular diseases, although accumulating evidence suggests that statins, such as simvastatin, also exert numerous anti-tumoral effects.

The pathogenesis of diabetic retinopathy (DR) remains unclear but hyperglycemia is an established risk factor. Endothelial dysfunction and changes in Ca(2+) signaling have been shown to precede the onset of DR. We recently demonstrated that high extracellular glucose activates the Ca(2+)/calcineurin-dependent transcription factor NFAT in cerebral arteries and aorta, promoting the expression of inf

Galectins are defined by a conserved beta-galactoside binding site, which has been linked to many of their important functions in e.g. cell adhesion, signaling and intracellular trafficking. Weak adjacent sites may enhance or decrease affinity for natural beta-galactoside containing glycoconjugates, but little is known about the biological role of this modulation of affinity (fine specificity). We

Photoinduced interaction of thioglycolic acid (TGA) capped CdTe quantum dots (QDs) with certain antioxidants such as estrogens and flavonoids has been investigated by using steady state and time resolved fluorescence spectroscopy. Reduction of electron-hole recombination has been observed (i.e., fluorescence quenching) while adding antioxidants to CdTe QDs. The Stern-Volmer constant (K-SV), quench

Niganda phichai Pellinen, sp. n., is described from northern Thailand. The new species is diagnosed and illustrated, including details of the genitalia and DNA sequencing. Variability in the male genitalia of Niganda radialis Gaede is reviewed, and notes are presented on the facies of female N. radialis

A comparative study of the central and southern parts of the Palaeoproterozoic Svecofennian orogen in the Baltic/Fennoscandian Shield and the platform area to the east and south of the Baltic Sea indicates that at least these parts of the orogen are built up of several NW-SE trending, 100-300 km wide tectonic megadomains separated from each other and complicated by major zones of mostly dextral sh

Back-arc volcanism in the western Argentinian provinces of Mendoza and Neuquen has been widespread from the Miocene to historic times. We present a detailed investigation of profiles through two of the major Miocene volcanic areas of the region, the neighboring Huantraico and La Matancilla plateaus, including new Ar-40/Ar-39 age results of major and trace elements as well as Nd, Sr and Pb isotopic

This manuscript presents the digital hardware realization of a wavelet based event detector for cardiac pacemaker applications. The architecture of the detector is partially folded to minimize hardware cost. An energy model is applied to evaluate the energy efficiency the sub-threshold (sub-VT ) domain. The design is synthesized in 65nm low leakage-high threshold CMOS technology, and it is shown t

The M-shell x-ray emission of highly charged tungsten ions has been investigated at the Livermore electron beam ion trap facility. Using the SuperEBIT electron beam ion trap and a NASA x-ray calorimeter array, transitions connecting to levels of the ground configurations in the 1500–3600 eV spectral range of zinc-like W44+ through cobalt-like W47+ have been measured. The measured spectra are compa

Abstract in UndeterminedUsing a sample of 7,260 university employees, we investigate how legitimacy, social and human capital influence the employees’ start-up propensity. We find that scientific legitimacy, as measured by the number of recently published peer reviewed scientific articles, and conference papers accepted had no significant effect. Scientific legitimacy measured as publications in n

Dyskinesias represent a major complication of dopamine replacement therapy in Parkinson's disease (PD) and have prompted a search for alternative treatments. The most radical advances in this field have been provided by surgical manipulations of the deep basal ganglia nuclei, and particularly by deep brain stimulation (DBS) of the subthalamic nucleus (STN). Although being very effective, high-freq

We describe two children with significant bleeding: one with multiple ecchymoses and the other with scrotal bleeding. In both patients, the activated partial thromboplastin time (APTT) was prolonged, with positivity for lupus anticoagulants (LA). However, the Owren prothrombin time (PT), usually insensitive for LA, was also prolonged. The presence of LA is associated with diverse clinical manifest

An updated search is performed for gluino, top squark, or bottom squark R-hadrons that have come to rest within the ATLAS calorimeter, and decay at some later time to hadronic jets and a neutralino, using 5.0 and 22.9 fb(-1) of pp collisions at 7 and 8 TeV, respectively. Candidate decay events are triggered in selected empty bunch crossings of the LHC in order to remove pp collision backgrounds. S

The signaling mechanisms controlling organ damage in the pancreas in severe acute pancreatitis (AP) remain elusive. Herein, we examined the role of farnesyltransferase signaling in AP.

Although previous studies have shown that people use both optic flow and target egocentric direction to walk or steer toward a goal, it remains in question how enriching the optic flow field affects the control of heading specified by optic flow and the control of target egocentric direction during goal-oriented locomotion. In the current study, we used a control-theoretic approach to separate the

Interest in monoclonal antibody aggregation is increasing as aggregates of biopharma-ceuticals can cause an immunogenic response when injected into the body. In this work a stoichiometric reaction model from concentration-time data is developed to predict the dimer ratio in stored antibody solutions over time. IgG1 was incubated at pH from 4.5 to 5.5, salt concentrations from 100 to 600 mmol/kg an

The purpose of the present study was to investigate the radiosensitivity of the prostate cancer cell lines LNCaP, DU145, and PC3 when irradiated with beta particles emitted from (177)Lu, and to compare the effect with irradiation using alpha particles or gamma rays.