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Objectives: To investigate informal caregivers’ psychological well-being and predicted increase in psychological well-being, when caring for persons with dementia (PwDs) living at home, related to caregiver, PwD and formal care (FC) factors. Method: A cohort study at baseline and 3 months’ follow-up in eight European countries. Caregivers included (n = 1223) were caring for PwDs aged ≥ 65 years at

The first of the so-called diffraction-limited storage rings (DLSRs), MAX I V, has now gone into operation. For this ring, a multibend achromat (MBA) lattice is employed in order to achieve a small electron beam emittance. Several non-conventional technical system solutions have been introduced in order to reduce size, cost, assembly time, installation effort and to increase the ring robustness. E

The MAX IV facility includes two storage rings operated at 1.5 GeV and 3 GeV. Both rings make use of a 100 MHz RF system and are designed to operate with a uniform multibunch fill pattern aswell as employ passive harmonic cavities to damp instabilities and increase Touschek lifetime. Recently, a discussion on timing modes at the MAX IV storage rings has been initiated by the user community. This i

The MAX IV facility includes two storage rings operated at 1.5 GeV and 3 GeV, which are both designed to operate with a uniform, multibunch fill pattern. Both rings have a 100 MHz RF system and employ passive harmonic cavities to damp instabilities and increase Touschek lifetime. Recently, a discussion on timing modes at the MAX IV storage rings has been initiated by the user community. Creating o

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An implicit water all-atom model is used to study folding, aggregation and mechanical unfolding of small proteins. Physically reasonable results obtained for a variety of applications indicate healthy global properties of the interaction potential.

Designing amino acid sequences that are stable in a given target structure amounts to maximizing a conditional probability. A straightforward approach to accomplish this is a nested Monte Carlo where the conformation space is explored over and over again for different fixed sequences. In this paper we discuss an alternative Monte Carlo approach, multisequence design, where conformation and sequenc

We study the phase behavior of single homopolymers in a simple hydrophobic/hydrophilic off-lattice model with sequence independent local interactions. The specific heat is, not unexpectedly, found to exhibit a pronounced peak well below the collapse temperature, signalling a possible low-temperature phase transition. The system size dependence at this maximum is investigated both with and without

We study a simple heteropolymer model containing sequence-independent local interactions on both square and triangular lattices. Sticking to a two-letter code, we investigate the model for varying strength κ of the local interactions; κ=0 corresponds to the well-known HP model [K. F. Lau and K. A. Dill, Macromolecules 22, 3986 (1989)]. By exhaustive enumerations for short chains, we obtain all str

A method for sequence optimization in protein models is presented. The approach, which has inherited its basic philosophy from recent work by Deutsch and Kurosky [Phys. Rev. Lett. 76, 323 (1996)] by maximizing conditional probabilities rather than minimizing energy functions, is based upon a different and very efficient multisequence Monte Carlo scheme. By construction, the method ensures that the

Folding properties of a two-dimensional toy protein model containing only two amino acid types, hydrophobic and hydrophilic, respectively, are analyzed. An efficient Monte Carlo procedure is employed to ensure that the ground states are found. The thermodynamic properties are found to be strongly sequence dependent in contrast to the kinetic ones. Hence, criteria for good folders are defined entir

The thermodynamic behavior of a three-dimensional off-lattice model for protein folding is probed. The model has only two types of residues, hydrophobia and hydrophilic. In absence of local interactions, native structure formation does not occur for the temperatures considered. By including sequence independent local interactions, which qualitatively reproduce local properties of functional protei