Background: Drug repurposing provides a cost-effective approach to address the need for breast cancer prevention and therapeutics. We aimed to identify actionable druggable targets using Mendelian randomization (MR) and then validate the candidate drugs using population-based analyses. Methods: We identified genetic instruments for 1406 actionable targets of approved non-oncological drugs based on

Résumé Français: Si l’écriture inclusive polarise largement l’opinion publique, les causes exactes des réticences envers son usage ne sont pas toujours très claires. Nous explorons les liens entre les attitudes envers l’écriture inclusive et différents facteurs, comme le niveau de connaissance linguistique ou historique de l’écriture inclusive. Nous avons également mesuré l’orientation politique dAlthough gender inclusive writing is widely polarised in public opinion, the exact causes of reluctance towards its use are not always clear. We explore the link between attitudes towards inclusive writing and different factors, such as the level of linguistic or historical knowledge of inclusive writing. We also measured the political orientation of the respondents, as well as their views on the

Models based on the Ornstein-Uhlenbeck process have become standard for the comparative study of adaptation. Cooper et al. (2016) have cast doubt on this practice by claiming statistical problems with fitting Ornstein-Uhlenbeck models to comparative data. Specifically, they claim that statistical tests of Brownian motion may have too high Type I error rates and that such error rates are exacerbate

Learning semantic-rich representations from raw unlabeled time series data is critical for downstream tasks such as classification and forecasting. Contrastive learning has recently shown its promising representation learning capability in the absence of expert annotations. However, existing contrastive approaches generally treat each instance independently, which leads to false negative pairs tha

Autophagy plays a critical role in the physiology and pathophysiology of hepatocytes. High level of homocysteine (Hcy) promotes autophagy in hepatocytes, but the underlying mechanism is still unknown. Here, we investigate the relationship between Hcy-induced autophagy level and the expression of nuclear transcription factor EB (TFEB). The results show that Hcy-induced autophagy level is mediated b

To explore the psychology of voting secrecy, we conducted a field experiment to examine voter sensitivity to arrangements for ballot paper selection under the French ballot system (i.e., multiple ballot papers). Working closely with Swedish election authorities, we randomly assigned participants to vote in a fictional election under low, medium-high and high privacy conditions with a follow up pap

We consider a class of weighted harmonic functions in the open upper half-plane known as α-harmonic functions. Of particular interest is the uniqueness problem for such functions subject to a vanishing Dirichlet boundary value on the real line and an appropriate vanishing condition at infinity. We find that the non-classical case (α ≠ 0) allows for a considerably more relaxed vanishing condition a

Purpose: Posterior fossa tumour surgery in children entails a high risk for severe speech and language impairments, but few studies have investigated the effect of the tumour on language prior to surgery. The current crosslinguistic study addresses this gap. We investigated the prevalence of preoperative word-finding difficulties, examined associations with medical and demographic characteristics,

Metal halide perovskites (MHPs) have garnered significant interest as promising candidates for nanoscale optoelectronic applications due to their excellent optical properties. Axially heterostructured CsPbBr3-CsPb(Br(1-x)Clx)3 nanowires can be produced by localized anion exchange of pregrown CsPbBr3 nanowires. However, characterizing such heterostructures with sufficient strain and real space reso

The European Society of Organ Transplantation (ESOT) strives to promote equity, diversity, and inclusion (EDI) across all its activities. We surveyed the transplant community’s experiences and perspectives regarding EDI within ESOT as an organization and its educational activities, and research in general. A total of 299 respondents completed the questionnaire. About half agreed that ESOT’s Execut

Singapore’s education system is globally recognized for its high academic standards. In this paper, I explore how Singaporean parents navigate sentiments of uncertainty and risk in relation to their children’s education. While academic achievements are still considered crucial to foster a competitive population, there has been a shift of attention in education policy towards social-emotional skillSingapore’s education system is globally recognized for its high academic standards. In this paper, I explore how Singaporean parents navigate sentiments of uncertainty and risk in relation to their children’s education. While academic achievements are still considered crucial to foster a competitive population, there has been a shift of attention in education policy towards social-emotional skill

The high energy electron beam was used for the local amorphisation of metallic multilayer. The observed effect is proposed for the application in nanometer-scale technology.

PTSD symptomatology is known to be associated with executive dysfunction. Inhibitory control is a core component of executive functioning, and inhibitory skills are essential both for adequate functioning in everyday life and important in situations following trauma. The aim of the present study was to examine the relationship between trauma exposure, inhibitory control and PTSD symptomatology in

Konsekvenserna av vad det blotta ögat inte når Epitelial äggstockscancer är den vanligaste dödsorsaken bland gynekologiska cancertyper, vilket beror av återkommande tumörer med resistens mot behandling. I cancerns slutstadier har jättecancerceller identifierats. Dessa formas till viss del av att två eller flera cancerceller smälter samman och kombinerar sitt yttre membran i bildandet en hybrid ce

Motivation: AliGater is an open-source framework to accelerate the development of bioinformatic pipelines for the analysis of large-scale, high-dimensional flow cytometry data. AliGater provides a Python package for automatic feature extraction workflows, as well as building blocks to construct analysis pipelines. Results: We illustrate the use of AliGater in a high-resolution flow cytometry-based

This chapter is a commentary on the book as a whole. Based on the overall PeTS project, the empirical findings from the four educational settings and the conceptual portions of the book, this chapter focuses on three specific aspects of peer group mentoring: the move from teaching as a private matter to teaching as a collegial responsibility, the relationship between collegiality and peer group me