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We have examined the effects of three macrophagederived cytokines, platelet-derived growth factor (PDGF), transforming growth factor-01 (TGF-01) and interleukin-1 a (IL-la) on the contraction of collagen type I gels populated by human foreskin fibroblasts. Contraction was quantified as loss in gel weight. Both PDGF-AA and PDGF-BB were found to induce a rapid collagen-gel contraction. TGF-/J1 also

The ISOLDE RIB-facility at CERN has today been producing a vast range of radioactive beams since more than 30 years. The low-energy beams of ISOLDE will be complemented by a post-accelerator, REX-ISOLDE, currently being assembled. In order to convert the pseudo-DC, singly-charged beam from the ISOLDE mass separators into a cooled and bunched beam at higher charge states, a novel scheme of trapping

We find effective, or homogenized, material parameters for Maxwell's equations when the microscopic scale becomes small compared to the scale induced by the frequencies of the imposed currents. After defining a singular value decomposition of the non-self-adjoint partial differential operator, we expand the electromagnetic field in the modes corresponding to the singular values and show that only

Different simple methods for evaluating the diffusivity from a sorption measurement are presented and tested when there is a surface resistance (a limited mass transfer coefficient), a non-perfect step in relative humidity or non-Fickian effects. It is concluded that the different methods have different qualities and it is impossible to give a general recommendation on which method to use. The bes

Although the calcineurin inhibitors (CNI) cyclosporine (CsA) and tacrolimus are highly effective immunosuppressants, they are associated with serious side effects. There is great interest in immunosuppressive regimens that permit reduction or elimination of CNIs, while maintaining adequate immunosuppression and acceptable acute rejection rates. Patients (n = 536) receiving their first renal allogr

Treatment of haemophilia is extremely costly due to the short biological half-life of infused factor and pricing issues. This paper examines the impact of different dosing schedules on factor consumption, via a review of literature on dosing regimens used for prophylaxis with a focus on pharmacokinetics (PK). Pharmacokinetics were found to have an important role for pharmacoeconomics in factor dos

Transmembrane receptors with intrinsic serine/threonine or tyrosine kinase domains regulate vital functions of cells in multicellular eukaryotes, e.g., differentiation, apoptosis, and proliferation. Here, we show that bone rnorphogenetic protein type II receptor (BMPR-II)which has a serine/threonine kinase domain, and stem cell factor receptor (c-kit) which contains a tyrosine kinase domain form a

The content of the globular domains G1, G2 and G3 on the core protein of high-density (A1D1) aggrecan isolated from newborn and mature bovine cartilage and from cultures of bovine chondrocytes was examined. Quantitation based on the 220 nm absorbance of tryptic marker peptides from each domain isolated by reversed-phase HPLC showed that while the content of G1 and G2 was essentially the same for a

Simulations with the Explicit Microphysics Model (EMM) of a case of lightly precipitating, glaciated stratiform cloud are presented. This frontal cloud was observed by the UK Met Office C-130 aircraft and the dual-polarization radar at Chilbolton in southern England. The Hallett-Mossop (H-M) process was found to cause extremely high number concentrations of crystal columns of up to almost 1000 1(-

The paper presents a design and discusses configuration aspects of an overlay transport protocol based on an idea of the peer-to-peer direct and anonymous distribution overlay (P2PRIV). We estimate a secure configuration of the protocol and examine a correlation between the P2PRIV’s anonymous path lengths and latency. An increase of the path lengths speaks strongly in favor of the parallel solutio

In shadow volume rendering, the shadow volume silhouette edges are used to create primitives that model the shadow volume. A common misconception is that the vertices on such silhouettes can only be connected to two silhouette edges, i.e., have degree two. Furthermore, some believe that such a vertex can have any degree. In this short note, we present a geometric proof that shows that the degree o

The moisture-induced warping of three-layered cross-laminated solid wood panels made of Norway spruce was studied. The panels were exposed to different climate conditions at 65% and 100% relative humidity at the two panel faces. The results showed increasing cup deformation with an increasing relative thickness of the outer layers. The annual growth ring orientation was found to have a significant

The basic bound on the generalisation error of a PAC learner makes the assumption that a consistent hypothesis exists. This makes it appropriate to apply the method only in the case where we have a guarantee that a consistent hypothesis can be found, something that is rarely possible in real applications. The same problem arises if we decide not to use a hypothesis unless its error is below a pres

We consider small systems of bosonic atoms rotating in a toroidal trap. Using the method of exact numerical diagonalization of the many-body Hamiltonian, we examine the transition from the Bose-Einstein condensed state to the Tonks-Girardeau state. The system supports persistent currents in a wide range between the two limits, even in the absence of Bose-Einstein condensation.

BACKGROUND. Leiomyosarcoma of soft tissue is a rare tumor. There are different opinions regarding epidemiology and prognosis. METHODS. Epidemiology and prognosis were analyzed in a consecutive, population-based series of 48 patients with subcutaneous and deep-seated leiomyosarcoma in the extremities and trunk wall with a complete follow-up of a minimum of 3 years. Cutaneous tumors were not include

Our aim was to compare hemiarthroplasty (HA) and osteosynthesis (OS) in the treatment of cervical hip fractures using matched-pair analysis, especially with regard to different age groups. Data concerning all hip fractures (excluding pathological fractures) at the University Hospitals of Lund in Sweden, where osteosynthesis with LIH hook-pins was used exclusively, and of Oulu in Finland, using mai