Tryptophan end-tagging for promoted lipopolysaccharide interactions and anti-inflammatory effects
The objective of the present study is the investigation of possibilities for boosting peptide antiinflammatory effects by tryptophan end-tagging, including identification of underlying mechanisms for this. In doing so, effects of tryptophan end-tagging of KYE21 (KYEITTIHNLFRKLTHRLFRR), a peptide derived from heparin co-factor II, on membrane and lipopolysaccharide (LPS) interactions were investiga