Sökresultat

Filtyp

Din sökning på "*" gav 530558 sökträffar

Real-world effectiveness of fremanezumab for the preventive treatment of migraine : Interim analysis of the pan-European, prospective, observational, phase 4 PEARL study

Background: The ongoing Pan-European Real Life (PEARL) phase 4 study is evaluating fremanezumab effectiveness and safety for the prevention of episodic and chronic migraine. This interim analysis reports primary, secondary and exploratory endpoints from when 500 participants completed at least six months of treatment. Methods: Adults with episodic migraine or chronic migraine maintaining daily hea

Performance of standardized cancer patient pathways in Sweden visualized using observational data and a state-transition model

Standardized Cancer Patient Pathways (CPPs) were introduced in Swedish healthcare starting in 2015 to improve diagnostics for patients with symptoms of cancer, patient satisfaction and equity of care between healthcare providers. An inclusion target and a time target were set. Our primary aim was to visualize the patient population going through CPPs, in terms of investigation time and indications

Global Bifurcation of Capillary-Gravity Water Waves With Overhanging Profiles and Arbitrary Vorticity

We study two-dimensional periodic capillary-gravity water waves propagating at the free surface of water in a flow with arbitrary, prescribed vorticity over a flat bed. Using conformal mappings and a new reformulation of Bernoulli's equation, the problem is equivalently cast into the form "identity plus compact", which is amenable to Rabinowitz's global bifurcation theorem, while no restrictions o

Staten och maten - kan skatter och subventioner rädda liv?

Kostintaget i Sverige följer inte Livsmedelsverkets rekommendationer. I den här studien undersöker vi om skatter och subventioner på livsmedel kan påverka människors matvanor och hälsa. Vi studerar skatter på produkter med hög andel mättade fetter och på produkter med hög andel salt, och hur de är relaterade till dödsfall från kostrelaterade sjukdomar. Vi undersöker även i vilken utsträckning subv

Understanding Corruption: An Interdisciplinary Socio-Legal Perspective

This article describes the mainstream global debates in the field of (anti-) corruption, discusses the main challengesto understanding and combating corruption, as well as introduces an interdisciplinary socio-legal perspective to the study of (anti-) corruption. Based on these global experiences, the article provides recommendations for developing an educational program in the field of (anti-) co

The Impact of Lending Relationships on the Lead Arrangers’ Retained Share

The lead arrangers of syndicated loans often have lending relationships with the borrowers, while other lenders participating in the syndicate largely engage in an arm’s length transaction. Relatively little is known about how these relationships affect the shares of syndicated loans that the lead arrangers retain in their portfolio. Using a random sample of 10,328 syndicated loans made to 7316 no

Clinical impact of medication reviews for community-dwelling patients in primary healthcare

Background: A high number of drug-related problems has previously been shown among community-dwelling patients in primary healthcare in Skåne County, Sweden. Medication reviews are one way to solve these problems, but their impact is largely dependent on the process. We aimed to evaluate medication reviews for community-dwelling patients regarding the clinical relevance of the pharmacists’ recomme

DDR1/2 enhance KIT activation and imatinib resistance of primary and secondary KIT mutants in gastrointestinal stromal tumors

Gastrointestinal stromal tumors (GISTs) are predominantly initiated by KIT mutations. In this study, we observed that discoidin domain receptors 1 and 2 (DDR1 and DDR2) exhibited high expression in GISTs, were associated with KIT, and enhanced the activation of both wild-type KIT and primary KIT mutants. Inhibition of DDR1/2 led to a reduction in the activation of KIT and its downstream signaling

Usability and feasibility of PreventS-MD web app for stroke prevention

Background: Most strokes and cardiovascular diseases (CVDs) are potentially preventable if their risk factors are identified and well controlled. Digital platforms, such as the PreventS-MD web app (PreventS-MD) may aid health care professionals (HCPs) in assessing and managing risk factors and promoting lifestyle changes for their patients. Methods: This is a mixed-methods cross-sectional two-phas

Cortical microvascular raspberries and ageing : an independent but not exclusive relationship

Introduction: Raspberries are cerebral microvascular formations of unknown origin, defined as three or more transversally sectioned vascular lumina surrounded by a common perivascular space. We have previously demonstrated an increased raspberry density in the cortex of patients with vascular dementia and cerebral atherosclerosis, while studies by other authors on overlapping and synonymously defi

Snack quality and snack timing are associated with cardiometabolic blood markers : the ZOE PREDICT study

Background: Snacking is a common diet behaviour which accounts for a large proportion of daily energy intake, making it a key determinant of diet quality. However, the relationship between snacking frequency, quality and timing with cardiometabolic health remains unclear. Design: Demography, diet, health (fasting and postprandial cardiometabolic blood and anthropometrics markers) and stool metagen

Impact of Added Thermal Insulation on Cold Attics in Apartment Buildings in Temperate Climate – A Review

Added insulation in cold attics can be an efficient and profitable energy efficiency measure. Simultaneously, added insulation increases the risk of a decreased temperature in the attic, thereby increasing the risk of high relative humidity and moisture damage. This paper collocates and reviews previous publications that deal with the impact of added insulation on attics as a renovation measure. T

Prevalence and prognostic value of electrocardiographic abnormalities in hypokalemia: A multicenter cohort study

AbstractBackgroundHypokalemia is common in hospitalized patients and associated with ECG abnormalities. The prevalence and prognostic value of ECG abnormalities in hypokalemic patients are, however, not well established.MethodsThe study was a multicentered cohort study, including all ault patients with an ECG and potassium level 100 bpm predicted both mortality and ICU admission among patients wit

Lost in translation–production, reproduction and transformation of teacher education knowledge in teacher educators’ local practices

European teacher educations today are expected to not only be ‘close to school practices’, but also to equip their students with academic knowledge. This article analyses one year of fieldwork data to discuss how these expectations are produced, reproduced and transformed in local practices by different categories of teacher educators (lecturers/assistant lecturers). The theory of practice archite

Measuring whole body inert gas wash-out

Introduction: Quantifying inert gas wash-out is crucial to understanding the pathophysiology of decompression sickness. In this study, we developed a portable closed-circuit device for measuring inert gas wash-out and validated its precision and accuracy both with and without human subjects. Methods: We developed an exhalate monitor with sensors for volume, temperature, water vapor and oxygen. Ine

A systematic review of differences in outcome between one and two stage palate repair in cleft lip and palate

The aim of this systematic review was to determine whether one-stage palatoplasty for children born with cleft lip and palate shows overall advantages in outcome compared with two-stage palatoplasty. The included studies were controlled studies of syndromic and non-syndromic children born with unilateral cleft lip and palate, bilateral cleft lip and palate, or isolated cleft palate. The interventi

Maternal and pregnancy predictive risk factors for having a compensated maternal injury claim : a Swedish nationwide cohort study

To describe trends and identify maternal and pregnancy predictive risk factors for having a compensated claim for a maternal injury during delivery, as a proxy for having received suboptimal care. This nationwide retrospective cohort study included 1 754 869 births in Sweden between 2000 and 2016, including 4488 maternal injury claims filed with The National Swedish Patient Insurance Company (Löf)

The Lucerne Toolbox 2 to optimise axillary management for early breast cancer : a multidisciplinary expert consensus

Clinical axillary lymph node management in early breast cancer has evolved from being merely an aspect of surgical management and now includes the entire multidisciplinary team. The second edition of the “Lucerne Toolbox”, a multidisciplinary consortium of European cancer societies and patient representatives, addresses the challenges of clinical axillary lymph node management, from diagnosis to l

Platelet transfusions in adult thrombocytopenic ICU patients : Protocol for a sub-study of the PLOT-ICU cohort

INTRODUCTION: Platelet transfusions are frequently used in intensive care unit (ICU) patients, but contemporary epidemiological data are sparse. We aim to present contemporary international data on the use of platelet transfusions in adult ICU patients with thrombocytopenia.METHODS: This is a protocol and statistical analysis plan for a post hoc sub-study of 504 thrombocytopenic patients from the