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Abstract in Romanian ntemeiată la 1348, Universitatea Carolină din Praga se numără printre cele mai vechi instituţii de învăţământ superior din lume. Studiul limbii române beneficiază aici de o bogată tradiţie, acesta fiind introdus la catedra de limbi romanice a Universităţii încă din anul 1882 de către profesorul ceh de filologie Jan Urban Jarník (1848-1923). Este notabil şi faptul că UniversitaFounded in 1348, Charles University in Prague is among the oldest academic institutions in the world. Teaching the Romanian language has a longstanding tradition as well: it was established by the Czech philologist Jan Urban Jarník (1848-1923) within the Romance Department in 1882. Thus Charles University in Prague became the fifth university outside Romania that began teaching Romanian language (

Tumour-educated macrophages display a mixed polarisation and enhance pancreatic cancer cell invasion.

At the time of diagnosis, almost 80% of pancreatic cancer patients present with new-onset type 2 diabetes (T2D) or impaired glucose tolerance. T2D and pancreatic cancer are both associated with low-grade inflammation. Tumour-associated macrophages (TAMs) have a key role in cancer-related inflammation, immune escape, matrix remodelling and metastasis. In this study, the interplay between tumour cel

Consequences of Subpopulation Structure on Fisheries Management: Cod (Gadus morhua) in the Kattegat and Oresund (North Sea)

This study shows how cod subpopulations may have been eradicated as a consequence of the use of imperfect models for assessing stock assessment, depleting what was formerly a productive sea. The Kattegat and Oresund (North Sea) were chosen as study objects due to the combination of different exploitation patterns and the possible existence of separate stock units. The scenario was further elaborat

Dissolution of dissolving pulp in alkaline solvents after steam explosion pretreatments

In this project different aqueous based solvent systems were investigated for the dissolution of steam exploded (STEX) dissolving pulps prior to a coagulation step for preparation of textile fibers. The pulp samples studied could, to a large degree, be dissolved in a NaOH/urea/thiourea system, but there are always residuals, irrespective of the conditions. The dissolution process appeared to be ki

Prediction of alignment deviations on a lead crowned helical gear manufactured by a hob

A drawback when hobbing lead crowned helical gears is that the gear tooth will be manufactured with alignment errors, often denoted flank twist. Together with other source deviations, these errors must not exceed the predetermined tolerances if the gear is to be finished hobbed. A simulation model is developed where the hobbing process can be analysed without additional errors resulting from real

Control of jet impingement heat transfer in crossflow by using a rib

Experimental studies are carried out to investigate the jet impingement heat transfer in crossflow by liquid crystal thermography (LCT). The aim is to assess the possibility of controlling heat transfer by using a rib. The crossflow Reynolds number spans from 80,000 to 160,000 and the velocity ratio ranges from 1.0 to 2.8. The results show that the presence of rib can significantly modify the heat

Analysis of ultrafast X-ray diffraction data in a linear-chain model of the lattice dynamics

We present ultrafast X-ray diffraction (UXRD) experiments which sensitively probe impulsively excited acoustic phonons propagating in a SrRuO3/SrTiO3 superlattice and further into the substrate. These findings are discussed together with previous UXRD results (Herzog et al. in Appl. Phys. Lett. 96, 161906, 2010; Woerner et al. in Appl. Phys. A 96, 83, 2009; v. Korff Schmising in Phys. Rev. B 78, 0

Energy-minimum sub-threshold self-timed circuits using current sensing completion detection

This study addresses the design of self-timed energy-minimum circuits, operating in the sub-VT domain and a generic implementation template using bundled-data circuitry and current sensing completion detection (CSCD). Furthermore, a fully decoupled latch controller was developed, which integrates with the current-sensing circuitry. Different configurations that utilise the proposed latch controlle

Forward-backward correlations and charged-particle azimuthal distributions in pp interactions using the ATLAS detector

Using inelastic proton-proton interactions at root s = 900 GeV and 7 TeV, recorded by the ATLAS detector at the LHC, measurements have been made of the correlations between forward and backward charged-particle multiplicities and, for the first time, between forward and backward charged-particle summed transverse momentum. In addition, jet-like structure in the events is studied by means of azimut

Structure-Property Relationship of Perylene Bisimide Macrocycles Probed by Atomic Force Microscopy and Single-Molecule Fluorescence Spectroscopy

Properties of a series of acetylene-linked perylene bisimide (PBI) macrocycles with different ring size composed of three to six PBI dyes were investigated by atomic force microscopy (AFM) and single-molecule fluorescence spectroscopy in a condensed phase. it was demonstrated that the structures of PBI cyclic arrays (CNs, N = 3, 4,5, and 6) become distorted with increasing the ring size through mo

The Social Construction of Globality

Today the concept of globality is widely used to describe a condition characterized by the presence a single sociopolitical space on a planetary scale. Yet international relations theory has been either unwilling or unable to understand the global realm in sui generis terms. This paper argues that if we want to make coherent sense of the global realm and its relationship to the international syste

Drivers of household food availability in sub-Saharan Africa based on big data from small farms.

We calculated a simple indicator of food availability using data from 93 sites in 17 countries across contrasted agroecologies in sub-Saharan Africa (>13,000 farm households) and analyzed the drivers of variations in food availability. Crop production was the major source of energy, contributing 60% of food availability. The off-farm income contribution to food availability ranged from 12% for hou

Survival and neonatal morbidity among extremely preterm born infants in relation to gestational age based on the last menstrual period or ultrasonographic examination

Objectives: The aim of this study was to investigate the potential impact of gestational age (GA) estimation on the basis of the last menstrual period (LMP) in comparison with GA based on ultrasound examination on rates of survival and neonatal morbidity among extremely preterm infants. Methods: The Swedish national registry of infants born extremely preterm (Extremely Preterm Infants in Sweden St

Apolipoprotein(a) Genetic Sequence Variants Associated With Systemic Atherosclerosis and Coronary Atherosclerotic Burden But Not With Venous Thromboembolism

Objectives The purpose of this study is investigate the effects of variants in the apolipoprotein(a) gene (LPA) on vascular diseases with different atherosclerotic and thrombotic components. Background It is unclear whether the LPA variants rs10455872 and rs3798220, which correlate with lipoprotein(a) levels and coronary artery disease (CAD), confer susceptibility predominantly via atherosclerosis

Geranylgeranyl transferase regulates streptococcal m1 protein-induced CXC chemokine formation and neutrophil recruitment in the lung.

ABSTRACT: Streptococcal toxic shock syndrome is most frequently associated with Streptococcus pyogenes of the M1 serotype. Simvastatin protects against M1 protein-induced acute lung damage, although downstream mechanisms remain elusive. Herein, we hypothesized that geranylgeranylation might regulate proinflammatory effects in M1 protein-induced lung injury. Male C57BL/6 mice received the geranylge

Smoking, low formal level of education, alcohol consumption, and the risk of rheumatoid arthritis.

Objective: Suggested predictors of rheumatoid arthritis (RA) include environmental exposure, such as smoking. Our purpose was to investigate potential predictors of RA in a nested case-control study based on a prospective cohort. Method: Between 1991 and 1996, 30 447 persons were included in the Malmö Diet and Cancer Study (MDCS). Individuals who developed RA after inclusion up to 31 December 2004

Ensuring the integrity of treatment parameters throughout the radiotherapy process.

BACKGROUND AND PURPOSE: Ensuring data integrity in radiotherapy is of major importance and a complex task. The aim of this study was to compare three different combinations of treatment planning and record and verify systems with respect to data integrity. MATERIALS AND METHODS: A software for comparison of treatment parameters in DICOM-RT files was developed using the MATLAB R2010a (MathWorks I

DAI-10 is as good as DAI-30 in schizophrenia

Drug attitude inventory (DAI-30) is considered to be the best predictor of poor adherence in first-episode schizophrenia. We compared the short version (DAM 0) with DAI-30 in long-term schizophrenia, documented if DAI was associated with poor insight, PANSS and GAF and constructed DAI-10 percentiles. DAI-30 and DAI-10 were homogenous (r = 0.82 and 0.72, respectively) with good test-retest reliabil