Filtyp
The CRISPR/Cas9 system has emerged as a transformative tool in genome editing, playing a pivotal role in enabling precise genetic engineering. Achieving high on-target efficiency while minimizing off-target activity is critical for translating CRISPR/Cas9 into reliable experimental and therapeutic applications. Conventional off-target detection methods are labor-intensive and cost-prohibitive, lim
Stadsmiljöavtal är ett sätt för staten att påverka kommuner och regioner att göra mer för att öka andelen hållbara transporter. Stadsmiljöavtalet introducerades 2015 som ett styrmedel för det ändamålet och Trafikverket fick i början av 2015 ett regeringsuppdrag att ta fram ett förslag på ett ramverk för stadsmiljöavtal. Syftet med denna rapport är att beskriva de faktiska effekterna av åtgärder oc
Plant membrane steroid binding proteins (MSBPs) belong to the membrane-associated progesterone receptors (MAPRs), which is present in all eukaryotic kingdoms. Plant MSBPs have been shown to regulate the function of cytochrome P450 enzymes, bind different steroidal compounds and confer salt tolerance. However, the exact molecular function of plant MSBPs remains elusive. Here, we perform a phylogene
Hemoglobin (Hb) can produce reactive oxygen species, including superoxide anions, which are intrinsically toxic. Superoxide dismutase (SOD) is present in red blood cells (RBCs) and provides important protection against such oxidative stress. Upon hemolysis, Hb becomes released from the RBCs and the normal protection systems involving SOD and catalase become very inefficient. In these instance
Medical waste management has been receiving increasing attention in recent years. The National Health Service (NHS) of the United Kingdom has started planning its waste strategy to comply with its Net Zero Goals. Waste management does not only involve waste disposal; the process includes segregation, collection, storage, and the transportation of waste from one point to another. Unusual characteri
The glymphatic system facilitates cerebrospinal fluid (CSF)-interstitial fluid exchange and plays a key role in solute clearance and neurophysiological homeostasis. While dysfunction of this system has been shown in traumatic brain injury, stroke, meningitis, idiopathic normal pressure hydrocephalus and neurodegenerative diseases, direct measurement of glymphatic transport in humans remains elusiv
BACKGROUND AND OBJECTIVE: Achieving adequate concentrations of beta-lactam antibiotics in patients with severe infections is challenging, and therefore therapeutic drug monitoring (TDM) would be optimal for guiding beta-lactam dosing, but is often limited by availability. UV/VIS spectrophotometry can quantify drug levels in saline, and if those levels truly reflect plasma concentrations, it could
The HLD-NAC (Hydrophilic-Lipophilic Difference - Net Average Curvature) equation of state is a powerful semi-empirical framework used to predict the phase behavior, solubilization, and interfacial properties of surfactant-oil-water (SOW) systems it is based on the assumption of a normalized curvature for an idealized microemulsion, represented as the coexistence of two fictitious phases: water dro
Konstnärlig forskning är ofta måltavla när välmenande röster vill värna konstens frihet. De artiklar om konstnärlig forskning som Kvartal publicerat av Jesper Andersson och Bogdan Szyber utgår dock från en förenklad och ofullständig bild av läget.
BACKGROUND AND PURPOSE: Pain as a long-term outcome following rectal cancer treatment has received limited attention in previous studies. This prospective cohort study examined pain prevalence up to 5 years post-surgery in patients treated with curative intent. Secondary aims included evaluating pain intensity and its interference with daily life, and comparing pain experiences with a reference po
We revisit the discussion on family limitation through stopping and spacing behavior both prior to and during the fertility transition. Using the birth histories of 13 519 settler women in nineteenth century South Africa we find no evidence of parity specific spacing prior to the transition. In addition we find no differences in spacing behavior based on differences in time invariant economic and
Background: Atherosclerotic cardiovascular disease is a chronic inflammatory process initiated when cholesterol-carrying low-density lipoprotein (LDL) is retained in the arterial wall. CD4+ T cells, some of which recognize peptide components of LDL as antigen, are recruited to the forming lesion, resulting in T-cell activation. Although these T cells are thought to be proatherogenic, LDL immunizat
Background: Chronic pain is a highly prevalent disease, leading to high health care costs, impaired productivity, and decreased quality of life. An artificial intelligence (AI)-powered, digital tool for self-management (PaindrainerTM) has been shown to be an effective treatment in chronic pain and may have potential to reduce the burden on costs and quality of life.Objective: The objective of thisBackgroundChronic pain is a highly prevalent disease, leading to high health care costs, impaired productivity, and decreased quality of life. An artificial intelligence (AI)-powered, digital tool for self-management (PaindrainerTM) has been shown to be an effective treatment in chronic pain and may have potential to reduce the burden on costs and quality of life.ObjectiveThe objective of this stu
While tau pathology is closely associated with neurodegeneration in Alzheimer's disease (AD), our prior work using multi-modality imaging revealed that mismatch between tau (T) and neurodegeneration (N) may reflect contributions from non-AD processes. The medial temporal lobe (MTL), an early site of AD pathology, is also a common target of co-pathologies such as limbic-predominant age-related TDP-
