Amyloid beta peptides (Aβ) proteins play a key role in vascular pathology in Alzheimer’s Disease (AD) including impairment of the blood–brain barrier and aberrant angiogenesis. Although previous work has demonstrated a pro-angiogenic role of Aβ, the exact mechanisms by which amyloid precursor protein (APP) processing and endothelial angiogenic signalling cascades interact in AD remain a largely un

Increased oxidative stress is implicated in the pathogenesis of Alzheimer's disease (AD). A large body of evidence suggests that mitochondrial dysfunction and increased reactive oxygen species occur prior to amyloid-β (Aβ) deposition. Coenzyme Q10 (CoQ10), a component of the mitochondrial electron transport chain, is well characterized as a neuroprotective antioxidant in animal models and human tr

Amyloid plaques, a well-known hallmark of Alzheimer's disease (AD), are formed by aggregated β-amyloid (Aβ). The cellular prion protein (PrPc) accumulates concomitantly with Aβ in amyloid plaques. One type of amyloid plaque, classified as a neuritic plaque, is composed of an amyloid core and surrounding dystrophic neurites. PrPc immunoreactivity reminiscent of dystrophic neurites is observed in ne

In this study, the authors describe the meanings of experiences of being dependent on a ventilator (HMV) and living at home as narrated by 13 people who had been using a ventilator via a mask or tracheostomy for half a year. The analyses revealed various movements across time toward the goal of using the ventilator successfully, and some narratives depicted suffering caused by care. The analyses a

Much has been written about models, aims and the concept of clinical group supervisional, although few studies are empirical or focus on intensive care. • The aim of the study was to illuminate the process and describe, using qualitative content analysis, the content of conversations carried out during the course of clinical group supervision sessions among Registered Nurses (RN) and enrolled nurs

Maternal hypoglycaemia throughout gestation until gestation day (GD)20 delays foetal growth and skeletal development. While partially prevented by return to normoglycaemia after completed organogenesis (GD17), underlying mechanisms are not fully understood. Here, we investigated the pathogenesis of these changes and significance of maternal hypoglycaemia extending beyond organogenesis in non-diabe

The repeatability of the composition of pheromone emitted by individual female moths (Yponomeuta) was determined by gas Chromatographic analysis. An improved technique for repeated collections of airborne volatiles from the same moth was developed. The procedure did not harm the females and allowed precise quantification of 0.05 ng of pheromone components in 30-min collections. Individual females

The intestine and the brain are connected via the brain-gut axis and the intestinal microbiota influences the immune activation and signaling molecules that are involved in the stress response. The aim of the study was to investigate if intake of the probiotic strain Lactiplantibacillus plantarum HEAL9 (LPHEAL9) for four weeks could counteract elevated cortisol and inflammation levels in subjects

Evacuation models generally tend to make over-simplifications in the representation of human behaviour in fire due to the difficulties to capture its complexity. This work shows how ‘new’ discrete choice model approaches allow overcoming this issue. A description of the existing state-of-the-art of discrete choice models is introduced to highlight the potential of those models. Three case studies

The first stages of planet formation take place in protoplanetary disks that are largely made up of gas. Understanding how the gas affects planetesimals in the protoplanetary disk is therefore essential. In this paper, we discuss whether or not gas flow can erode planetesimals. We estimated how much shear stress is exerted onto the planetesimal surface by the gas as a function of disk and planetes

Rapid deforestation is a major sustainability challenge, partly as the loss of carbon sinks exacerbates global climate change. In Cambodia, more than 13% of the total land area has been contracted out to foreign and domestic agribusinesses in the form of economic land concessions, causing rapid large-scale land use change and deforestation. Additionally, the distant drivers of local and global env

Objectives To examine the under-reporting of pharmaceutical company payments to patient organisations by donors and recipients. Design Comparative descriptive analysis of payments disclosed on drug company and charity regulator websites. Setting UK. Participants 87 donors (drug companies) and 425 recipients (patient organisations) reporting payments in 2012-2016. Main outcome measures. Number and

Allogeneic hematopoietic cell transplantation is an established treatment for hematologic and other malignancies. Donor-derived immune cells can identify and attack host tumor cells, producing a graft-versus-tumor (GVT) effect that is crucial to the treatment. Using multiple tumor models and diverse donor-host combinations, we have studied the role of granzyme B (GzmB) in GVT effect. We first conf

The presence of paralytic shellfish poisoning toxins (PSTs) in drinking water resources has urged the development of simple and fast screening tools for drinking water surveillance. This article aims to validatea quick test kit for freshwater PSTs detection. Preliminary estimates of the limit of detection (LODs)were done for 5 PSPs variants, namely C1 toxin (a “C” toxin); GTX5(a Gonyautoxin); and