Experimental models implicate protease activated receptors (PARs) as important sensors of the proteolytic tumor microenvironment during breast cancer development. However, the role of the major PARs, PAR-1 and PAR-2, in human breast tumors remains to be elucidated. Here, we have investigated how PAR-1 and PAR-2 protein expression correlate with established clinicopathological variables and patient

Background: Overweight and obesity in younger children could better be brought in focus through a deeper understanding of how Child Health Care nurses (CHC-nurses) perceive their work with the problems of overweight at the CHC Centers. The aim of this study was to elucidate the CHC-nurses conceptions of their preventive work with childhood overweight and obesity in Child Health Care. Method: A qua

Background The metabolic syndrome (MetS) may contribute to the increased cardiovascular risk in systemic lupus erythematosus (SLE). We examined the association between MetS and disease activity, disease phenotype and corticosteroid exposure over time in patients with SLE. Methods Recently diagnosed (< 15 months) patients with SLE from 30 centres across 11 countries were enrolled into the Systemic

Background: Ischemic postconditioning (PostC), reperfusion in brief cycles, is known to induce short-term reduction in infarct size in patients with ST elevation myocardial infarction (STEMI), especially among those with large myocardium at risk (MaR). The aim of the present study was to investigate the long-term effect of PostC on infarct size and left ventricular ejection fraction (LVEF). Method

Objective. The association between smoking and idiopathic inflammatory bowel disease is well known; smoking seems to have a diverse effect. Crohn's disease is associated with smoking, while ulcerative colitis is associated with non-smoking. Data on smoking in microscopic colitis of the collagenous type (CC) are lacking. The aim of this investigation was to study smoking habits in CC and to observe

This Letter presents measurements of correlated production of nearby jets in Pb+Pb collisions at root s(NN) = 2.76 TeV using the ATLAS detector at the Large Hadron Collider. The measurement was performed using 0.14 nb(-1)of data recorded in 2011. The production of correlated jet pairs was quantified using the rate, R-Delta R, of "neighbouring" jets that accompany "test" jets within a given range o

Current theory suggests that mass change in adult birds while breeding may be adaptive (to reduce wing-loading during nestling feeding) or result from physiological stress. To test which might be more important in determining mass loss in breeding Savi's Warblers (Locustella luscinioides), we used a new approach in which the variation in four indices of body condition was described: weight, fat sc

Abstract in Undeterminedhis survey deals with computational complexity of column generation problems arising in the design of survivable communication networks. Such problems are often modeled as linear programs based on noncompact multicommodity flow network formulations. These formulations involve an exponential number of path-flow variables, and therefore require column generation to be solved

Objectives Lymphotoxin beta (LTB) has been found to be upregulated in salivary glands of patients with primary Sjogren's syndrome (pSS). An animal model of pSS also showed ablation of the lymphoid organisation and a marked improvement in salivary gland function on blocking the LTB receptor pathway. This study aimed to investigate whether single-nucleotide polymorphisms (SNP) in the lymphotoxin alp

All birds were counted along six permanent routes (total length 90 km) located in the low alpine zone (800–1000 m.a.s.l.) at Ammarnäs, southern Lapland, during fortyyears, 1972–2011. Eighty-three species were recorded; average 41 species and 1677 birds per year. Number of species as well as population size increased for waterfowl, waders and other non-passerines but not for passerines. Thirteen of

A major challenge with single-nucleotide polymorphism (SNP) fingerprinting of bacteria and higher organisms is the combination of genome-wide screenings with the potential of multiplexing and accurate SNP detection. Single-nucleotide extension by the minisequencing principle represents a technology that both is highly accurate and enables multiplexing. A current bottleneck for direct genome analys

Popular Abstract in Swedish Bakgrund: Patientflödet genom en akutmottagning regleras framförallt av tre typer av faktorer. Dessa rör i tur och ordning inflödet-, genomflödet- och utflödet av patienter. Faktorer som reglerar inflödet rör efterfrågan på sjukvård (t.ex. samhällsdemografi och tillgång på primärvård), medan faktorer som reglerar genomflödet till största delen rör akutmottagningens inteBackground: Emergency Department (ED) overcrowding occurs when the need for ED services outstrips available resources. Causes have been divided into input, throughput, and output factors, of which the last appear to be the most influential. Unavailability of inpatient beds (so-called “access block,” or “hospital crowding”) impairs ED output and is associated with increased waiting times in the ED

A low-diversity Early Jurassic flora preserved in floodbasin siltstones of the Marburg Subgroup at Inverleigh Quarry in the Clarence-Moreton Basin, eastern Australia, is dominated by Allocladus helgei Jansson sp. nov., a conifer with denticulate leaves tentatively attributed to Araucariaceae. The assemblage also includes Rintoulia variabilis and Caytoniales, (Caytonia cucullata McLoughlin sp. nov.

Missionärsfamiljen Blomstrands arbete i Indien under 1800-talet och tidigt 1900-tal, och familjekorrespondensen mellan Indien och Sverige.

This article investigates and discusses a football chant, a riff from a popular rock song entitled “Seven Nation Army” by the rock group The White Stripes from Detroit, USA. The chant is sung by supporters at football matches even in Sweden but also in corresponding social contexts, as when high school students graduate or at the pub. The survey, which was to by a reduction method compare the riff