BACKGROUND: Despite absence of level 1 evidence on the long-term oncological safety of non-operative management for rectal cancer (watch and wait), increased implementation has occurred globally over the past decades. In Sweden, a pan-national prospective non-randomized study was initiated in 2017 to assess its implementation.METHOD: Patients with biopsy-proven rectal cancer receiving neoadjuvant

This chapter explores the relationship between people and forests during Japan’s Tokuagwa period, focusing on Hirosaki domain in northern Honshu, known for its abundant hiba (thujopsis dolabrata) forests. Timber production thrived in the seventeenth century, but by the eighteenth century, resource depletion prompted forest management policies. The 1783 famine accelerated forest devastation, leadin

BACKGROUND: Inadequate or excessive nociceptive control during general anesthesia can result in significant adverse outcomes. Using traditional clinical variables, such as heart rate, systolic blood pressure, and respiratory rate, to assess and manage nociceptive responses is often insufficient and could lead to overtreatment with both anesthetics and opioids. This study evaluated the feasibility

Group III-V semiconductor nanowires are a material platform with potential applications in electronics,photovoltaics and optoelectronic devices. One of the central challenges in the growth of III-V semiconductornanowires is to understand the dynamic processes that occur during crystallization. However, the growth of thesematerials is commonly performed in closed systems. There the details of the g

Germline mutations are the ultimate source of genetic diversity, and germline mutation rate is central to evolutionary biology. However, while germline mutations primarily arise during DNA replication in the parental germline and should accumulate with increasing parental age, studies showed that germline mutation rate does not necessarily track germ cell divisions. This suggests that germline mut

Germline mutations (GMs) are the ultimate source of genetic diversity, and germline mutation rate (GMR) isthus central to evolutionary biology. However, while GMs primarily arise during DNA replication in the parentalgermline and should accumulate with increasing parental age, studies showed that GMR does not necessarilytrack germ cell divisions. This suggests that GMR is subjected to selection an

Periodic dredging of harbors and other waterways is carried out to ensure suffi-cient depth for navigation. The Stabilization/Solidification method (S/S) is theglobal approach for improving the geotechnical characteristics and stabilizingpollutions in the low-compressive-strength dredged sediment (DS) for land rec-lamation. For this, different binders, such as cement, fly ash, and slag, are mixedw

Data anonymization has been used as a fundamental tool in various domains, e.g. healthcare, to alter personal data such that individuals can no longer be identified directly or indirectly in a way to enable broader sharing of data. For example, data perturbation techniques add noise to original data allowing individual record confidentiality while maintaining high-quality data for analytical purpo

Healthcare longitudinal data collected around patients' life cycles, today offer a multitude of opportunities for healthcare transformation utilizing artificial intelligence algorithms. However, access to "real" healthcare data is a big challenge due to ethical and legal reasons. There is also a need to deal with challenges around electronic health records (EHRs) including biased, heterogeneity, i

Phenomenal virtuoso trumpeter Håkan Hardenberger is ready to dazzle Turku for the third time! Jolas' "Eleven Songs" is a jazz tickler, a sparkly biting, at times dreamy and above all playful composition. Haydn's Concerto, one of his most popular works, will be freshly interpreted by the evening's artists. Conductor John Storgårds and TPO:s Dvořák cycle begins with the composer's breakthrough symph

Burlesque comes to The Bridgewater Hall in Stravinsky’s electrifying ballet, Petrushka, meanwhile the spotlight shines on one of the world’s most distinguished trumpet players, Håkan Hardenberger, all with Chief Conductor John Storgårds at the reins. Pieces performed by Håkan Hardenberger:Joseph Haydn: Konzert für Trompete und Orchester Es-Dur Hob. VIIe:1 Betsy Jolas: Onze Lieder (1977) für Trompe

In the context of the European Commission’s work to further the EuropeanGreen Deal, Executive Vice-President Maroš Šefčovič requested theEuropean Group on Ethics in Science and New Technologies (EGE) to issuea series of three Opinions providing ethical perspectives on different aspectsof the green transition.The Scoping Considerations provided by the Vice-President note that thequestions raised by

Since life emerged on Earth, organisms have had to handle threats and stressors of different kinds. In freshwater ecosystems, one of these ancient stressors is the solar ultraviolet (UV) radiation. Life has been continuously exposed to it, and various behavioural and morphological adaptations have evolved to cope with the stressor. On the other hand, human activities have introduced novel stressor