Binding of complement regulators to invasive nontypeable Haemophilus influenzae is not increased compared to nasopharyngeal isolates, but serum resistance is linked to disease severity.
The aim of the present study was to analyse the importance for non-typeable Haemophilus influenzae (NTHi) isolated from patients with sepsis (invasive isolates) compared to nasopharyngeal isolates from patients with upper respiratory tract infection to resist the complement-mediated attack in human serum and to correlate this to disease severity. We in detail studied and characterized cases of inv