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Chemical and Clinical Studies of Isocyanate Contact Allergy with focus on diphenylmethane diisocyanate

Popular Abstract in Swedish I detta arbete studerades olika aspekter av lapptestdiagnostiken vid misstänkt kontaktallergi mot en grupp ämnen som kallas isocyanater. Dessa ämnen innehåller reaktiva isocyanatgrupper med den kemiska strukturen -N=C=O. Isocyanater används framförallt vid tillverkningen av polyuretan (PUR) som bildas när iso-cyanater reagerar med flerfunktionella alkoholer till en polyIsocyanates are highly reactive compounds used in the production of polyurethane. Exposure to isocyanates is mainly associated with respiratory disorders, but may also result in allergic contact dermatitis. Reports describing contact allergy to isocyanates are few in number and it has been considered a rare phenomenon. In the present study it is shown that the low frequency of reported cases could

Transmission rates and phenotypic effects of mitochondrial plasmids and cytotypes in Silene vulgaris

We investigated the transmission properties and the phenotypic effects of two mitochondrial plasmids in a population of the bladder campion, Silene vulgaris. In reciprocal crosses between plasmid-free and plasmid-carrying plants, no cases of paternal transmission or loss during maternal transmission were recorded. Neither was any transmission via pollen observed when plasmid-carrying plants of S,

Abnormal collagen fibrils in tendons of biglycan/fibromodulin-deficient mice lead to gait impairment, ectopic ossification, and osteoarthritis

Small leucine-rich proteoglycans (SLRPs) regulate extracellular matrix organization, a process essential in development, tissue repair, and metastasis. In vivo interactions of biglycan and fibromodulin, two SLRPs highly expressed in tendons and bones, were investigated by generating biglycan/fibromodulin double-deficient mice. Here we show that collagen fibrils in tendons from mice deficient in bi

Leachability testing of sludge from street gullies

Sludge from gullies, on two types of streets with different traffic intensity, was investigated using two recommended EU methods for leachability testing of waste: a two-stage batch test and an up-flow percolation test. The main purpose of this investigation was to gain more knowledge about these leaching test methods to be able to make future decisions on the general applicability of the proposed

Selective supercritical fluid extraction to identify aged sediment-bound PCBs available for uptake by eel

A naturally contaminated sediment was partially extracted with selective supercritical fluid extraction (SFE) to remove a fraction of supposedly bioavailable PCBs from the matrix. Eels (Anguilla anguilla) were cultured in systems with untreated and pre-extracted sediment, respectively, and it was shown that the SFE treatment selectively removed bioavailable PCBs from the sediment, since relative b

Iterative channel estimation and data detection in frequency-selective fading MIMO channels

Signals transmitted through multiple-input multiple-output (MIMO) wireless channels buffer from multiple-access interference (MAI), multipath propagation and additive noise. Iterative multiuser algorithms mitigate these signal impairments. while offering a good tradeoff between performance and complexity. The receiver presented in this paper performs channel estimation. multiuser detection and dec

Variation in sapflow and stem growth in relation to tree size, competition and thinning in a mixed forest of pine and spruce in Sweden

The aim of this study was to analyse the relationship between different biometric parameters and sapflow and growth, respectively, in order to assess their potential for use in scaling. The effect of thinning on these relationships was also investigated. The studied stand consisted of Scots pine (ca. 60%), Norway spruce (ca. 35%) and downy birch (ca. 5%). Sapflow was measured by the tissue heat-ba

PREVENTION OF POSTSURGICAL ABDOMINAL ADHESIONS BY POLYPEPTIDES

Popular Abstract in Swedish Sammanväxningar i buken utvecklas efter flertalet kirurgiska bukingrepp och utgör en betydande orsak till tarmvred, buksmärta och infertilitet. Buksammanväxningar skulle potentiellt kunna minskas i omfattning med användande av förebyggande behandling men här finns klara begränsningar i exempelvis effekt och ett stort utrymme för förbättring. De i denna avhandling ingåenPeritoneal adhesions develop after almost all abdominal surgical interventions and represent an important cause of postoperative intestinal obstruction, abdominal discomfort and infertility. Postoperative adhesions can potentially be reduced by using different antiadhesive agents. In the present study, we hypothesized that a combination of oppositely charged polypeptides could effectively decrease

Survival of patients with kyphoscoliosis receiving mechanical ventilation or oxygen at home

Background: Home mechanical ventilation (HMV) and long-term oxygen therapy (LTOT) are the two treatment alternatives when treating respiratory insufficiency in patients with kyphoscoliosis. We aimed to study the effect on survival with regard to HMV or LTOT alone in patients with respiratory insufficiency due to kyphoscoliosis. Methods: Swedish patients with nonparalytic kyphoscoliosis (ie, scolio

Influence of sympathetic stimulation on the mechanical properties of the aorta in humans

The mechanical properties of the aorta play a major role in the regulation of blood pressure and cardiac performance. The effect of sympathetic stimulation on the mechanical properties of the human abdominal aorta was studied in 19 healthy volunteers, divided into young (25 +/- 2 years) and elderly individuals (69 +/- 2 years) of both sexes. A non-invasive ultrasonic echo-tracking system for measu

Existence, Uniqueness, and Causality Theorems for Wave Propagation in Stratified, Temporally Dispersive, Complex Media

A mixed initial-boundary value problem for a nonlocal, hyperbolic equation is analyzed with respect to unique solubility and causality. The regularity of the step response and impulse response (the Green functions) is investigated, and a wave front theorem is proved. The problem arises, e.g., at time-varying, electromagnetic, plane wave excitation of stratified, temporally dispersive, bi-isotropic

From probabilistics to determinism: an essay on risk assessment and decisionmaking in sociotechnical systems

Probabilistic analysis is the usual starting point for sociotechnical risk assessments aimed at deciding whether or not a particular risk is acceptable. However, the available probabilistic evidence is usually insufficient as a basis for such decisions, and so the assessment has to be supplemented by a judgemental process of a more deterministic nature. This concluding phase in decisionmaking is e

Simultaneous quantification of human glandular kallikrein 2 and prostate-specific antigen mRNAs in peripheral blood from prostate cancer patients

We present a multiplexed and internally calibrated quantitative reverse transcription-PCR (QRT-PCR) assay to detect human glandular kallikrein 2 (hK2) and prostate-specific antigen (PSA) transcripts in blood samples from healthy subjects and prostate cancer (PC) patients. The assay detected 50 copies of hK2 and PSA mRNA, and 1 PSA- and 10 hK2-expressing LNCaP cells in the presence of 2.5 x 10(6) P