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Modified Peritoneal Flap Hernioplasty Versus Retromuscular Technique for Incisional Hernia Repair : a Retrospective Cohort Study

Background and Aims: We present an open retromuscular mesh technique for incisional hernia repair, the modified peritoneal flap hernioplasty, where the fascia is sutured to the mesh and the hernia sac utilized for anterior mesh coverage. The aim was to describe the modified peritoneal flap hernioplasty technique and to compare it to a retromuscular repair, without component separation, regarding s

Regulation of Human Papillomavirus Type 16 Early and Late Gene Expression

Human papillomavirus type 16 (HPV16) is a cancer-causing virus that contributes to at least 70% of cervical cancer as well as to other anogenital cancers and head and neck cancer. Understanding HPV16 gene regulation is important to enhance our understanding of HPV16 infections and may contribute to development of antiviral drugs. In this study, we show that nucleosides/nucleoside analogues have th

Measurement of airway inflammation in current smokers by positron emission tomography

Background: Accumulation of activated neutrophilic leucocytes is known to increase uptake of 18F-fluorodeoxyglucose (18F-FDG) into lung tissue. Available evidence suggests that smokers and subjects with chronic obstructive pulmonary disease (COPD) have neutrophilic inflammation in peripheral airways. The aim of this study was to examine whether current smokers have higher lung tissue uptake of 18F

Risk and outcome of hepatocellular carcinoma in liver cirrhosis in Southern Sweden : a population-based study

Background and aims: Liver cirrhosis is a risk factor for hepatocellular carcinoma (HCC). While the HCC risk is thought to be highest in hepatitis B and hepatitis C, the risk in other cirrhosis etiologies is not fully established. Therefore, we aimed to study the risk and outcome of HCC in alcoholic cirrhosis compared to cirrhosis of other etiologies, in Sweden. Material and methods: We used popul

Placing emotion and fantasy at the heart of the researcher-researched relationship : The contribution of psychosocial studies

Purpose: The purpose of this paper is to introduce psychosocial research methodology as a method that makes use of the emotions of researcher and researched and goes well-beyond empathetic understanding. Design/methodology/approach: This short piece critically introduces the recently published book Further Researching Beneath the Surface (Volume 2): Psycho-social Research Methods in Practice, Eds

Hypoxia with acidosis in extremely preterm born infants was not associated with an increased risk of death or impaired neurodevelopmental outcome at 6.5 years

Aim: It is not clear whether perinatal acidosis can predict poor outcomes in extremely preterm infants and we investigated associations between intrapartum hypoxia and mortality and neurodevelopmental outcomes. Methods: We used nationwide data on 705 infants from the Extremely Preterm Infants in Sweden Study, delivered at 22-26 weeks of gestation during 2004-2007. Comprehensive neurodevelopmental

Neutrophil extracellular trap-microparticle complexes trigger neutrophil recruitment via high-mobility group protein 1 (HMGB1)-toll-like receptors(TLR2)/TLR4 signalling

Background and Purpose: Recent data suggest that neutrophil extracellular traps (NETs) form aggregates with microparticles (MPs) upon activation of neutrophils although the functional role of NET-MP complexes remain elusive. The objective of this study was to examine the role of NET-MP aggregates in leukocyte recruitment in vivo. Experimental Approach: PMA stimulation of murine bone marrow neutrop

Who should record surgical complications? Results from a third-party assessment of complications after radical cystectomy

Objective: In Sweden complications after radical cystectomy have been reported to the nationwide population-based Swedish Cystectomy Registry since 2011. Here, validation of the reporting was assessed in two healthcare regions. Materials and methods: Complications were ascertained from patient records by a third party not involved in the care delivered to 429 randomly selected patients from 949 wh

80-kVp hepatic CT to reduce contrast medium dose in azotemic patients : a feasibility study

Background: Low peak kilovoltage (kVp) computed tomography (CT) may be used to reduce contrast medium doses in patients at risk of contrast medium-induced acute kidney injury if image noise can be controlled by increasing X-ray tube loading (mAs). Purpose: To evaluate objective and subjective image quality in 80-kVp CT with reduced contrast medium dose and compensated mAs for unchanged image noise

Body image in relation to nutritional status in adults from the Basque Country, Spain

The aim of this research was to analyse variation in body image perception and satisfaction by age, sex and nutritional status in an adult sample from the Basque Country, Spain. A case-control study was performed for 227 women and 178 men aged 18-70 years. Stunkard's silhouettes were used to evaluate Current Body Image (CBI) and Ideal Body Image (IBI), as well as dissatisfaction and inconsistency

Solidarity with/out Borders

This blog post is a summary of the main points raised in our paper ‘The EU building borders: West Africa, Western Balkans and the Mediterranean’ that was presented at the RLI Fourth Annual Conference in London, UK. In this paper we essentially ask how solidarity works between the Schengen countries and how this feeds into the externalization of the EU migration policy debate.

CMR feature tracking in cardiac asymptomatic systemic sclerosis : Clinical implications

BACKGROUND: Impaired myocardial deformation has been sporadically described in cardiac asymptomatic systemic sclerosis (SSc). We aimed to study myocardial deformation indices in cardiac asymptomatic SSc patients using cardiac magnetic resonance feature tracking (CMR-FT) and correlate these findings to the phenotypic and autoimmune background.METHODS: Fifty-four cardiac asymptomatic SSc patients (4

Oxygen supply to immobilized cells : 2. Studies on a coimmobilized algae-bacteria preparation with in situ oxygen generation

A coimmobilized mixed culture of algae, Chlorella pyrenoidosa, and bacteria, Gluconobacter oxydans, has been studied. The conversion of glycerol to dihydroxyacetone(1,3-dihydroxy-2-propanone), catalysed by the bacteria, was used to indicate the oxygen supply in the immobilized preparation. The oxygen produced by the algae in the coimmobilized preparation was used by the bacteria more effectively t

Oxygen supply to immobilized cells : 1. Oxygen production by immobilized Chlorella pyrenoidosa

Oxygen supply at high cell densities of aerobic organisms is a great problem in immobilized cell preparations. To investigate the possibility of in situ oxygen generation the alga Chlorella pyrenoidosa was immobilized on alginate beads. The conditions for optimal oxygen production were investigated and in long term experiments the preparations were successful for at least 30 days.

Low prevalence of known pathogenic mutations in dominant PD genes : A Swedish multicenter study

Objective: To determine the frequency of mutations known to cause autosomal dominant Parkinson disease (PD) in a series with more than 10% of Sweden's estimated number of PD patients. Methods: The Swedish Parkinson Disease Genetics Network was formed as a national multicenter consortium of clinical researchers who together have access to DNA from a total of 2,206 PD patients; 85.4% were from popul

Divide and rule Cyprus? Decolonisation as process

Instances of decolonisation can be considered processes featuring complicated interactions that are both path-depended and open-ended. This perspective contrasts with reductionist epistemologies, particularly economistic ones. Viewing the decolonisation of Cyprus in processual terms, this article argues that the process at hand was crucially shaped by the colonial strategy of divide-and-rule and t