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Respiratory viral infections cause exacerbations of asthma and COPD that cannot be effectively treated today. Thymic Stromal Lymphopoietin (TSLP) is an upstream epithelial cytokine linking the innate and adaptive immune system. Viral stimuli induce epithelial overexpression of TSLP in asthma and COPD. We hypothesise that TSLP switches on Th2-type inflammation in severe asthma/COPD. A deficient ant
Nuclear shell evolution in neutron-rich Na nuclei around N = 20 was studied by determining reduced transition probabilities, i.e., B(E2) and B(M1) values, in order to map the border of the island of inversion. To this end Coulomb-excitation experiments, employing radioactive Na-29,Na-30 beams with a final beam energy of 2.85 MeV/nucleon, were performed at REX-ISOLDE, CERN. De-excitation gamma rays
Abstract in Danish Denne artikel stiller skarpt på nogle af de fremtrædende neo-marxistiske teoretikere,der de seneste årtier har bidraget til vores forståelse af samfundet, den politiske økonomi, nye sociale bevægelser og rummet.
Biogeographic gradients may facilitate divergent evolution between populations of the same species, leading to geographic variation and possibly reproductive isolation. Previous work has shown that New Zealand triplefin species (family Tripterygiidae) have diversified in habitat use, however, knowledge about the consistency of this pattern throughout their geographic range is lacking. Here we exam
The classical pathway complement regulator C4b-binding protein (C4BP) is composed of two polypeptides (alpha- and beta-chains), which form three plasma oligomers with different subunit compositions (alpha(7)beta(1), alpha(7)beta(0), and alpha(6)beta(1)). We show in this article that the C4BP alpha(7)beta(0) isoform (hereafter called C4BP[beta(-)] [C4BP lacking the beta-chain]), overexpressed under
We present the abundance analysis for a sample of 7 red giant branch stars in the metal-poor globular cluster NGC 4372 based on UVES spectra acquired as part of the Gaia-ESO Survey. This is the first extensive study of this cluster from high-resolution spectroscopy. We derive abundances of O, Na, Mg, Al, Si, Ca, Sc, Ti, Fe, Cr, Ni, Y, Ba, and La. We find a metallicity of [Fe/H] = -2.19 +/- 0.03 an
In other hazardous complex socio-technical systems in society, e.g. nuclear power and aviation, systems-theoretical assumptions are considered a promising way to better understand and manage safety. In this paper, two fundamental approaches to road safety were assessed in the light of a systems theory approach. One approach, is based on a premise where individual road-users are solely responsible
The function of alpha-cells in patients with type 2 diabetes is often disturbed; glucagon secretion is increased at hyperglycaemia, yet fails to respond to hypoglycaemia. A crucial mechanism behind the fine-tuned release of glucagon relies in the exocytotic machinery including SNARE proteins. Here, we aimed to investigate the temporal role of syntaxin 1A and SNAP-25 in mouse alpha-cell exocytosis.
Research on nutrient controls of planktonic productivity tends to focus on a few standard fractions of inorganic or total nitrogen (N) and phosphorus (P). However, there is a wide range in the degree to which land-derived dissolved organic nutrients can be assimilated by biota. Thus, in systems where such fractions form a majority of the macronutrient resource pool, including many boreal inland wa
The present thesis concerns the involvement of EWSR1 and FUS fusion genes, and the chimeric proteins they encode, in tumorigenesis. In Article I, the EWSR1 promoter, which regulates the expression of EWSR1 fusion genes, was characterized and regions that were crucial for promoter activity could be identified. The sequence was found to have bidirectional activity and is likely to regulate also RHBD
For functions. f is an element of L-1 (R-n) we consider extensions to R-n x R+ given by convolving f with an approximate identity. Fora large class of approximate identities we obtain a Fatou-type theorem where the convergence regions are sometimes effectively larger than the non-tangential ones. We then study a more restricted class of approximate identities for which the convergence regions are
This article discusses the advantages of the the Coherence Based Genealogical Method (CBGM), not only as a tool for reconstructing the text of the New Testament, but also for surveying the history of readings and for explaining textual changes. The CBGM promises to detect readings, which have emerged several times independently in the textual tradition. The method is applied to selected examples i
Background. Observational studies have suggested that BCG may have nonspecific beneficial effects on survival. Low-birth-weight (LBW) children are not given BCG at birth in Guinea-Bissau; we conducted a randomized trial of BCG at birth (early BCG) vs delayed BCG. Methods. In the period 2004-2008 we recruited 2320 LBW children in Bissau. The children were visited at home at 2, 6, and 12 months of a
