Partially premixed combustion (PPC) is a promising way to achieve high thermal efficiency and low emissions, especially by using multiple injection strategies. The mechanisms behind PPC efficiency are still to be explained and explored. In this paper, multiple injections have been used to affect the gross indicated efficiency in an optical PPC engine modified from a Volvo MD13 heavy-duty diesel en

Background: The estrogen receptor (ER) can change expression between primary tumor (PT) and distant metastasis (DM) in breast cancer. A tissue biopsy reflects a momentary state at one location, whereas circulating tumor cells (CTCs) reflect real-time tumor progression. We evaluated ER-status during tumor progression from PT to DM and CTCs, and related the ER-status of CTCs to prognosis. Methods: I

Obesity is a risk factor for type 2 diabetes (T2D); however, not all obese individuals develop the disease. In this study, we aimed to investigate the cause of differential insulin secretion capacity of pancreatic islets from donors with T2D and non-T2D (ND), especially obese donors (BMI ≥30 kg/m2). Islets from obese donors with T2D had reduced insulin secretion, decreased β-cell exocytosis, and h

Cell therapy raises hopes high for better treatment of brain disorders. However, the majority of transplanted cells often die soon after transplantation, and those that survive initially continue to die in the subacute phase, diminishing the impact of transplantations. In this study, we genetically modified transplanted human neural stem cells (hNSCs), from 2 distant embryonic stem cell lines (H9

Collaborative innovation is necessary to explore and implement circular economy strategies. Yet, empirical investigations into such collaborations are scarce. It is unclear whether the circular context creates differences or represents adaptions within how collaborative innovation is conducted. We draw upon strategic management and open innovation literature to highlight what is known about collab

Present debates suppose a close linkage between economic, social, and environmental sustainability and suggest that individual wellbeing and living standards need to be understood as directly linked to environmental concerns. Because social movements are often seen as an avant-garde in pushing for change, this article analyzes climate protesters' support for three key frames in current periods of

Remarkable flight performance is key to the survival of adult Odonata. They integrate varied three-dimensional architectures and kinematics of the wings, unsteady aerodynamics, and sensory feedback control in order to achieve agile flight. Therefore, a diverse range of approaches are necessary to understand their flight strategy comprehensively. Recently, new data have been presented in several ke

Research into the bicycle level-of-service (BLOS) has been extensively conducted over the last three decades. This research has mostly focused on user perceptions of comfort to provide guidance for decision-makers and planners. Segments and nodes were studied first, followed by a network evaluation. Besides these investigations, several variables have also been utilized todepict the users’ perspec

Originally believed to primarily affect neurons, Parkinson's disease (PD) has recently been recognized to also affect the functions and integrity of microglia and astroglia, two cell categories of fundamental importance to brain tissue homeostasis, defense, and repair. Both a loss of glial supportive-defensive functions and a toxic gain of glial functions are implicated in the neurodegenerative pr

Background: Allergic rhinoconjunctivitis is a public health problem. Allergen Immunotherapy is an effective and safe treatment, that modifies the natural course of allergic disease and induces long-term tolerance. Objective: To correlate basophil and antibody biomarkers of subcutaneous immunotherapy to clinical outcomes and cellular changes in target tissue. Methods: Adults suffering from allergic

Hypomyelination is observed in the context of a growing number of genetic disorders that share clinical characteristics. The aim of this study was to determine the possible role of magnetic resonance imaging pattern recognition in distinguishing different hypomyelinating disorders, which would facilitate the diagnostic process. Only patients with hypomyelination of known cause were included in thi

Religious organizations are social systems operating in a complex and changing environment. By looking to an authority beyond themselves, religious organizations have comparatively little control over defining their own goals. In this juggling between sticking to the ultimate goal of an organization and adapting to complex changing environments, that is, in the juggling between tradition and renew

Software developers use collection data structures extensively andare often faced with the task of picking which collection to use.Choosing an inappropriate collection can have major negativeimpact on runtime performance. However, choosing the right collectioncan be difficult since developers are faced with many possibilities,which often appear functionally equivalent. One approachto assist develo

The influence of the sintering temperature on the mechanical properties of cBN-based ceramic composites with binders in form of vanadium compounds is investigated by methods of physical material science. Two compositions are selected for the study cBN–VC–Al and cBN–VN–Al with 60% vol. of cBN. Samples are obtained by high pressure high temperature sintering (HPHT) in toroid type apparatus with cent

This paper focuses on the interaction of manual and automatic control in a demanding task where the process is unstable and has actuator limitation. The problem is inspired by control of high performance aircrafts but which is similar to controlling the arm of a Furuta pendulum while maintaining the stability of the pendulum. The task is to control the position of the pendulum arm manually while m

This paper reports a study of pupils’ experiences of media and information literacy education in five Swedish schools by answering the following overarching question, what roles do the teaching of information seeking and critical assessment of information play for pupils in their school-work as well as in their everyday life? Pupils in ninth grade were asked to fill in a questionnaire regarding th

Background: Previous studies have found that the incidence of dementia is lower in patients with cancer. However, the impact of survival bias, as well as the confounding by medical treatment, have not been fully addressed. We aimed to explore the subsequent risk of dementia in different follow-up intervals among patients with cancer, as well as the risk before the diagnosis of cancer. Methods: By

The excessive use of pesticides is a serious health problem due to their toxicity and bioaccumulation through the food chain. Due to the complexity of foods, the analysis of pesticides is challenging often giving large matrix effects and co‐extracted compounds. To overcome this problem, a selective and “green” supercritical fluid extraction method was developed, using neat carbon dioxide as a solv

Ancient remains found in permafrost represent a rare opportunity to study past ecosystems. Here, we present an exceptionally well-preserved ancient bird carcass found in the Siberian permafrost, along with a radiocarbon date and a reconstruction of its complete mitochondrial genome. The carcass was radiocarbon dated to approximately 44-49 ka BP, and was genetically identified as a female horned la