BACKGROUND: Understanding how lineage choices are made during embryonic stem (ES) cell differentiation is critical for harnessing strategies for controlled production of therapeutic somatic cell types for cell transplantation and pharmaceutical drug screens. The in vitro generation of dopaminergic neurons, the type of cells lost in Parkinson's disease patients' brains, requires the inductive molec

The long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been recently shown to be dysregulated in several cancers. However, the mechanisms underlying the role of MALAT1 in breast cancer remain unclear. Herein, we showed that MALAT1 was aberrantly increased in breast cancer tissues and cells. MALAT1-siRNA inhibited breast cancer cell proliferation and ce

Diabetic wounds result in significant morbidity, prolonged hospitalization, and enormous health-care expenses. Pigs have been shown to have wound healing resembling that in humans. The aim of this study was to develop a large-animal model for diabetic wound healing. Diabetes was induced by streptozotocin injection in Yorkshire pigs. Full-thickness wounds were created and dressed with a sealed cham

Elements of the Ordovician conodont genus Protopanderodus have been investigated in order to provide a model of reconstruction for its oral apparatus. In total, 4202 elements from the five named species representing this genus in the Swedish Middle Ordovician are included in this study; P. rectus, P. parvibasis, P. graeai, P. robustus, and P. calceatus. The well-preserved specimens were studied in

This paper considers a generic one-warehouse multiple-retailer inventory system under continuous review, where customers provide perfect advance-order information. More specifically, each customer order entails a due date specifying when the customer wants the item delivered. The information is perfect in the sense that a placed order cannot be revised. With the intent of using the advance-order i

Minimal encephalopathy was originally associated with chronic liver disease but is increasingly associated with most other chronic diseases and particularly with diabetes and also chronic disorders in other organs: kidneys, lungs, thyroid and with obesity. It is increasingly with dramatically increased and more or less permanent increase in systemic inflammation, most likely a result of Western li

The 4d state in Na, which recently has been studied in several two-photon absorption experiments, was investigated by level-crossing spectroscopy. For the fine structure splitting we find the value 1028.3(6) MHz.