Maturation of lymphoid cells is controlled by the action of stage and lineage-restricted transcription factors working in concert with the general transcription and chromatin remodeling machinery to regulate gene expression. To better understand this functional interplay, we used Biotin Identification in human embryonic kidney cells to identify proximity interaction partners for GATA3, TCF7 (TCF1)

Membrane proteins perform a vast range of vital biological functions and are the gatekeepers for exchange of information and matter between the intracellular and extracellular environment. However, membrane protein interactions can be challenging to characterise in a quantitative manner due to the low solubility and large size of the membrane protein complex with associated lipid or detergent mole

Neuroblastoma is a childhood malignancy with often dismal prognosis; relapse is common despite intense treatment. Here, we used human tumor organoids representing multiple MYCN-amplified high-risk neuroblastomas to perform a high-throughput drug screen with approved or emerging oncology drugs. Tumor-selective effects were calculated using drug sensitivity scores. Several drugs with previously unre

Purpose: Estimated glomerular filtration rate (eGFR) is commonly used to calculate carboplatin doses and capping the eGFR may be used to reduce the risk of excessive dosing and toxicity. We sought to retrospectively examine the impact of our carboplatin guidelines on pathological complete response rates (pCR) and toxicity in women with HER2+ breast cancer receiving neoadjuvant docetaxel, carboplat

Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive tumors, accounting for around 5% of all soft tissue sarcomas. A better understanding of the pathogenesis of these tumors and the development of effective treatments are needed. In this context, established tumor cell lines can be very informative, as they may be used for in-depth molecular analyses and improvement of treatment strate

Recension av Hedvig Mollestads skiva Ekhidna

This chapter provides an attempt to enable a productive conversation between the budding, interdisciplinary research field of celebrity studies, humanitarianism, and activism and feminist international political economy scholarship. It focuses on the Same Sky shopping initiative – a New York-based ethical trade and shopping initiative supported by a philanthropic foundation with the same name. The

This paper presents a measurement-based analysis of 39 GHz millimeter wave (mm-wave) radio propagation through vegetation using an ultra-wideband (UWB) channel sounder. The measurement campaign was conducted in a suburban area on campus of Tongji University, Shanghai, China. Two different kinds of measurements were performed to investigate the foliage influence on the characteristics of radio prop

This paper presents a measurement-based analysis of wideband 39 GHz millimeter wave (mm-wave) dual-polarized propagation channel under the impact of foliage presence between a transmitter (Tx) and a receiver (Rx). The measurements were conducted in a rich-vegetation area, and the so-called direction-scan-sounding (DSS) method which rotates a horn antenna in angular domains was applied, aiming at i

The presentation is focused on the representations of stop consonants in Anatolian (Hittite and Luwian) loans in Ugaritic, and what these representations can teach us about early Anatolian and Indo-European phonology; lately, Northwest Semitic consonantal reflexes in such loans have been an important area for discussion given the many uncertain-ties of the actual realization of Anatolian stops and

Skäl för att överväga huruvida skäl för ett beslut, i frånvaron av bevis, bör berättiga beslutsfattande i särskilda omständigheter presenteras. Det föreslås att en distinktion mellan skäl och bevis baserad på deras tid-indexikala olikheter ger oss skäl att, i särskilda omständigheter, formulera beslutsfattandeprocedurer som inte, utöver skäl, också kräver bevis för premisserna för beslutet. Invänd

Recension av sociologen Roland Paulsens bok Tänk om - en studie i oro

The research subject is the Swedish History Museum in Stockholm as a public institution between 1943 and 2013. I examine how public spaces in the museum body are designed in relation to cultural policy objectives and the museum’s vision of a democratic, inclusive museum. However, the focus is not on the museum’s exhibits, but on other public spaces visitors encounter in the museum, mainly the entr