The term gastrointestinal neuromuscular disease describes a clinically heterogeneous group of disorders of children and adults in which symptoms are presumed or proven to arise as a result of neuromuscular, including interstitial cell of Cajal, dysfunction. Such disorders commonly have impaired motor activity, i.e. slowed or obstructed transit with radiological evidence of transient or persistent

Popular Abstract in Swedish Bakgrund: Patientflödet genom en akutmottagning regleras framförallt av tre typer av faktorer. Dessa rör i tur och ordning inflödet-, genomflödet- och utflödet av patienter. Faktorer som reglerar inflödet rör efterfrågan på sjukvård (t.ex. samhällsdemografi och tillgång på primärvård), medan faktorer som reglerar genomflödet till största delen rör akutmottagningens inteBackground: Emergency Department (ED) overcrowding occurs when the need for ED services outstrips available resources. Causes have been divided into input, throughput, and output factors, of which the last appear to be the most influential. Unavailability of inpatient beds (so-called “access block,” or “hospital crowding”) impairs ED output and is associated with increased waiting times in the ED

We present high-resolution computer simulations of dust dynamics and planetesimal formation in turbulence generated by the magnetorotational instability. We show that the turbulent viscosity associated with magnetorotational turbulence in a non-stratified shearing box increases when going from 256(3) to 512(3) grid points in the presence of a weak imposed magnetic field, yielding a turbulent visco

This thesis focuses on local food systems in Sweden, using examples from the Farmers’ Markets that are a growing phenomena in Sweden, as well as in many other developed countries across Europe and the Americas and many other developed countries. Farmers’ Markets are about consumers and producers reconnecting and re-establishing the relationships of trust and transparency that are lacking in today’

Treeline encroachments and retractions can provide global-scale feedbacks to the climate system, and treeline dynamics are therefore of great relevance for understanding global climate variability. To assess the accuracy of long-term treeline simulations based on the generalized dynamic vegetation model LPJ-GUESS, we simulate European Arctic treeline dynamics over the past 9000 years and compare t

The posttranslational modification of proteins has the potential to generate neoepitopes that may subsequently trigger immune responses. The carbamylation of lysine residues to form homocitrulline may be a key mechanism triggering inflammatory responses. We evaluated the role of carbamylation in triggering immune responses and report a new role for this process in the induction of arthritis. Immun

Breast cancer is a very heterogeneous disease in terms of clinical characteristics, genetic aberrations and prognosis. In Paper I, we focused on the CD44 molecule that often is aberrantly expressed in breast cancer and is widely used as a marker for cancer stem cells. Several isoforms of the CD44 molecule were analyzed at the transcriptome level across breast tumors and the expression of individua

The interactions of biological macromolecules with nanoparticles underlie a wide variety of current and future applications in the fields of biotechnology, medicine and bioremediation. The same interactions are also responsible for mediating potential biohazards of nanomaterials. Some applications require that proteins adsorb to the nanomaterial and that the protein resists or undergoes structural

Background: The innate immune system contributes to the outcome after stroke, where neuroinflammation and post-stroke systemic immune depression are central features. Tumor necrosis factor (TNF), which exists in both a transmembrane (tm) and soluble (sol) form, is known to sustain complex inflammatory responses associated with stroke. We tested the effect of systemically blocking only solTNF versu

Partially Premixed Combustion (PPC) is a combustion concept by which it is possible to get low smoke and NOx emissions simultaneously. PPC requires high EGR levels to extend the ignition delay so that air and fuel mix prior to combustion to a larger extent than with conventional diesel combustion. This paper investigates the operating region of single injection PPC for three different fuels; Diese

This survey, "Life and Health-Young People 2005," included all 15/16-year-old adolescents in mainstream schools in the county of Orebro, Sweden. just students with a slight/mild or moderate hearing loss were included. There were 56 (1.9%) "hard-of-hearing (HH) students with multiple disabilities," 93 (3.1%) students who were "just HH," 282 (9.7%) students with some "other disability than HH," and

Projekt Turnstone är ett samverkansprojekt delvis finansierat av Europeiska kommissionen. Projektet är ett initiativ av Stockholmspolisens gränsbevakningsenhet. Syftet med Projekt Turnstone är att minska gränsöverskridande brottslighet, förbättra dagligt samarbete mellan gräns, polis och kustbevakare i Östersjöregionen och förbättra säkerheten för passagerare i Östersjöregionen utan att göra avkalProject Turnstone is a collaborative project funded in part by the European Commission. The project is an initiative by the Stockholm Police. The purpose of the project is to improve day-to-day cooperation between border officers in the Baltic Sea region, decrease trans-boundary criminality, and increase security for passengers in the Baltic Sea area without compromising freedom of movement. Withi

Popular Abstract in Swedish Människans immunförsvar ska hjälpa oss att bekämpa infektioner från bakterier och virus. Immunförsvaret kan delas in i två delar; det adaptiva immunförsvaret, som utvecklas hela tiden under livets gång, samt det medfödda immunförsvaret. De flesta känner kanske till att kroppen kan utveckla antikroppar mot bakterier. Antikroppar känner igen och markerar ut främmande struAbstract: The joint diseases osteoarthritis and rheumatoid arthritis are characterized by destructive inflammatory processes that result in pathological changes of the joint tissues, including proteolytic degradation of cartilage and release of extracellular matrix proteins or fragments to the synovial fluid. The complement system, which is a part of the innate immune system, plays a central role

The Ebola virus (EBOV) RNA-dependent RNA polymerase (RdRp) complex consists of the catalytic subunit of the polymerase, L, and its cofactor VP35. Using immunofluorescence analysis and coimmunoprecipitation assays, we mapped the VP35 binding site on L. A core binding domain spanning amino acids 280-370 of L was sufficient to mediate weak interaction with VP35, while the entire N-terminus up to amin

Popular Abstract in Swedish Bland infektionssjukdomarna är Enterobacteriaceae den viktigaste gruppen av bakterier. Den kan orsaka ett flertal olika infektioner så som blodförgiftning, urinvägsinfektion, hjärnhinneinflammation, bukhinneinflammation, gallvägsinfektioner, lunginflammation och diarrésjukdomar. Den vanligaste orsaken till blodförgiftning är bakterier som har kommit in i blodet från uriIn human medicine, the most important family of bacteria is Enterobacteriaceae, which includes genera and species that cause well-defined diseases and also nosocomial infections. These bacteria can give rise to numerous infections such as septicaemia and urinary tract infections. It is important to combat these infections with effective antibiotics, because many of them are associated with high mo

Cationic vinylpyridine based molecularly imprinted polymer monoliths were, for the first time, applied to enantiomer separation using capillary electrochromatography. In order to map the synthesis conditions under which superporous monoliths are obtained, capillary columns were prepared by an in situ polymerization technique using varying monomer and porogen compositions. Both electrolyte pH and p