Sökresultat

Makrocykliska peptider är en ny typ av läkemedelskandidater som kan påverka mål i kroppen som vanliga läkemedel ofta inte kommer åt – till exempel när två proteiner ska interagera. Trots att dessa peptider är relativt stora och komplexa, har vissa visat sig kunna tas upp i kroppen vid tablettintag, något som annars är ovanligt för större molekyler. Men det är fortfarande oklart vilka egenskaper soMacrocyclic peptides (MCPs) are a promising drug modality for targeting protein–protein interactions, offering high selectivity, metabolic stability, and potential cell permeability. However, predicting their membrane permeability remains challenging due to their conformational flexibility, environment-dependent polarity, and ability to adopt chamaleonic behavior, e.g. by changing the number of in

This study examines how the Riksbank’s asset purchase program influenced the Swedish economy over time. The research question is: How have the Riksbank’s asset purchases affected key macroeconomic outcomes in Sweden? To address this, the analysis focused on inflation, unemployment, and housing prices, three central indicators of both monetary policy transmission and real economic impact. Two econo

Bakgrund: Röstbesvär förekommer ofta inom röstkrävande yrken och kan påverka arbetsförmågan påtagligt. Trots detta saknas det tillförlitliga självskattningsinstrument som specifikt fångar hur röstbesvär påverkar arbetsförmågan. Work Hoarse har utvecklats för att fylla denna lucka. Syfte: Syftet med studien var att genomföra en språklig översättning och kulturell anpassning av självskattningsinstruBackground: Voice problems are prevalent in vocally demanding professions and may impact work ability. Nevertheless, there is a lack of reliable self-assessment tools that specifically measure impact of voice disorders on work ability. The self-assessment tool Work Hoarse was developed to address this gap. Aim: This study aimed to translate and adapt Work Hoarse linguistically and culturally into

Syftet med denna kandidatuppsats är att undersöka hur mjukvaruutvecklare upplever användningen av Continuous Integration och Continuous Delivery (CI/CD) i praktiken, samt hur dessa metoder påverkar arbetsflödeseffektivitet, kodkvalitet och samarbete utifrån tekniska och organisatoriska faktorer. Studien bygger på sex semistrukturerade intervjuer med utvecklare från olika organisationer och analyse

Due to the climate crisis we are facing, we can no longer consider current construction methods, which contribute to 40% of global CO₂ emissions, as an alternative to building. Vernacular architecture, in comparison, offers a sustainable alternative. People have experimented with this approach to designing, constructing, and living throughout time. This system essentially stands for maximizing eff

This study investigated the effects of Rhizopus oryzae and Lactiplantibacillus plantarum 299V fermentation on Swedish yellow peas. Through 48 hours of fermentation, the pH and acidity development were investigated, and the final samples underwent analysis regarding their polyphenol and antioxidant content to determine the effect of the fermentation. Furthermore, the samples underwent an in vitro d

Invasiva plattmaskars introduktion i ett land kan innebära ett allvarligt hot för jordens bördighet och jordbruket. Många arter äter nämligen daggmaskar, som är en organism som hjälper till med många avgörande ekosystemtjänster i förnan. Plattmaskar är ett hett ämne i Sverige just nu, följande den oavsiktliga introduktionen av Obama nungara i november 2024, som har daggmaskar som byte. DaggmaskarIn Sweden, the topic of invasive flatworms is as relevant as ever following the recent introduction of the species Obama nungara. Invasive flatworms are predators of earthworms which indirectly makes them a threat to soil quality ecosystem services. These services provided by earthworms play an important part in a sustainable agriculture system because of their effect on the quality of soil. The a

In Latin America, gender-based violence and barriers to reproductive autonomy remain widespread. This paper investigates the association between women’s experience of intimate partner violence (IPV) and contraceptive behavior, focusing on three dimensions: use, choice of method effectiveness, and discontinuation. I perform a cross-sectional analysis with binary and multinomial logistic regressions

Den växande efterfrågan på hållbara förpackningslösningar har ökat fokus på återvinningsbarhet av plastkomponenter, inklusive plastlock. Graphic Packaging International (GPI) syftar till att göra sina förpackningar mer återvinningsbara. Vissa av deras kunder är dock ännu inte redo att byta från plast till papper. En lovande möjlighet är att göra plastlocket helt avtagbart, vilket möjliggör enklareThe growing demand for sustainable packaging solutions has increased the focus on recyclability of plastic components, including plastic lids. Graphic Packaging International (GPI) aims to make their packaging more recyclable. However, some of their customers are still not ready to switch from plastic to paper yet. One promising opportunity is to make the plastic lid fully removable, allowing easi

This study was conducted to better understand the complex behavior of dual-fuel diesel-ammonia combustion in compression ignition engines, with the aim of developing a simulation model that could replicate experimental results. The work specifically explores how changes in modeling parameters—such as swirl intensity and initial temperature—affect fuel-air mixing, ignition behavior, and emissions f

Photovoltaic (PV) technology will be a crucial part of shifting the energy sector towards more sustainable electricity production. However, conventional ground- mounted PV systems often compete for arable land, leading to land-use conflicts between the energy sector and the agricultural food sector. Agrivoltaics (APV), can bridge this conflict by integrating solar energy production with farming on

AI-powered vehicle systems, including autonomous driving features and advanced driver assistance systems (ADAS), are becoming increasingly integrated into modern automotive development. While these technologies offer benefits such as improved functionality, innovation acceleration, and competitive advantage, they also introduce new challenges. One of the key challenges is maintaining system safety

We study how small, fine-tuned generative large language models (LLMs) can moderate free-text search queries for surveillance video systems. Four open models, Llama 3.2 1B, Llama 3.2 3B, Qwen 2.5 0.5B, and 1.5 B, are trained on six subtasks: safety judgement, problem detection, target detection, span detection, safety explanation, and rephrase. The training combines a public toxicity set with abou

During the winter smog season, Punjab experiences some of the world’s most hazardous air quality levels, largely driven by the open-field burning of agricultural residue. In response, the provincial government introduced a 60 percent subsidy for Super Seeders — tractor-mounted implements that mulch crop residue in-field, eliminating the need for burning. This thesis presents a formative, farmer-ce

The EU’s Carbon Border Adjustment Mechanism has received growing scholarly attention. However, it’s impact on firm strategic behavior remains understudied. This thesis presents a qualitative interview-based research framework to capture private sector behavior. The study utilizes eight expert interviews conducted with firm employees and stakeholders and interprets these results through an inducti

Den här kvalitativa studien har som syfte att undersöka ledarskap som en roll och hur ledarskap formas genom social interaktion, inom studentföreningar vid Lunds universitet. Tidigare studier har gjorts på chefsroller och ledarpositioner inom yrkesverksamheter, men det saknas forskning på ledarskap bland studentföreningar och utifrån studenters egna perspektiv. Via tio stycken semistrukturerade in

The aim of this thesis was to study protein-ligand interactions in the binding pocket of galectin-3C and galectin-8N through X-ray crystallography. Ligands in different stages of their development state were crystallized in complex with their respective target protein. In total, two protein-ligand complexes were structurally solved for galectin-3C, and one partially for galectin-8N. The structures

The integration of renewable energy sources such as solar and wind power is steadily increasing, which introduces challenges such as voltage fluctuations, reduced system stability, and lower power quality. Battery Energy Storage Systems (BESS) can support the grid by providing services such as frequency regulation and peak shaving, contributing to a more stable and energy-efficient power system.