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Sexual dimorphism in a top predator (Notophthalmus viridescens) drives aquatic prey community assembly
Intraspecific variation can have important consequences for the structure and function of ecological communities, and serves to link community ecology to evolutionary processes. Differences between the sexes are an overwhelmingly common form of intraspecific variation, but its community-level consequences have never been experimentally investigated. Here, we manipulate the sex ratio of a sexually
Protected areas act as a buffer against detrimental effects of climate change—Evidence from large-scale, long-term abundance data
Climate change is driving species to shift their distributions toward high altitudes and latitudes, while habitat loss and fragmentation may hamper species ability to follow their climatic envelope. These two drivers of change may act in synergy, with particularly disastrous impacts on biodiversity. Protected areas, PAs, may thus represent crucial buffers against the compounded effects of climate
Profiling dendritic cell subsets in head and neck squamous cell tonsillar cancer and benign tonsils.
Dendritic cells (DCs) have a key role in orchestrating immune responses and are considered important targets for immunotherapy against cancer. In order to develop effective cancer vaccines, detailed knowledge of the micromilieu in cancer lesions is warranted. In this study, flow cytometry and human transcriptome arrays were used to characterize subsets of DCs in head and neck squamous cell tonsill
Interdependence and the Biblical Legacy of Anthropocentrism : On Human Destructiveness and Human Responsibility
This article engages with the biblical legacy of anthropomorphism from a contemporary perspective. First, it revisits the biblical creation myth and questions the deeply ingrained notion that what it offers is an account of ‘creation out of nothingness.’ Second, this rereading is followed by a closer look at how this particular theology was elaborated by Hans Jonas in his philosophy of life. In th
Color matrix element corrections for parton showers
We investigate the effects of keeping the full color structure for parton emissions in parton showers for both LEP and LHC. This is done within the Herwig 7 dipole shower, and includes gluon emission, gluon splitting, initial state branching processes, as well as hadronization. The subleading Nc terms are included as color matrix element corrections to the splitting kernels by evolving an amplitud
Coagulation biomarkers and prediction of venous thromboembolism and survival in small cell lung cancer : A sub-study of RASTEN - A randomized trial with low molecular weight heparin
Coagulation activation and venous thromboembolism (VTE) are hallmarks of cancer; however, there is an unmet need of improved biomarkers for individualized anticoagulant treatment. The present sub-study of the RASTEN trial was designed to explore the role of coagulation biomarkers in predicting VTE risk and outcome in a homogenous cancer patient population. RASTEN is a multicenter, randomized phase
Assays for Studying the Role of Vitronectin in Bacterial Adhesion and Serum Resistance
Bacteria utilize complement regulators as a means of evading the host immune response. Here, we describe protocols for evaluating the role vitronectin acquisition at the bacterial cell surface plays in resistance to the host immune system. Flow cytometry experiments identified human plasma vitronectin as a ligand for the bacterial receptor outer membrane protein H of Haemophilus influenzae type f.
On the relationship between the Cartesian and the ontological way to the transcendental reduction in the phenomenological philosophy of Edmund Husserl
This paper assesses a discussion on how to understand the relationship between Husserl’s Cartesian way and the later ontological way to the transcendental reduction: Is the Cartesian way flawed to the extent that the ontological way constitutes a principal correction to it, or is the ontological way a logical completion of an insufficient but nonetheless necessary Cartesian way? A reading with the
Nonperturbative transverse-momentum-dependent effects in dihadron and direct photon-hadron angular correlations in p+p collisions at s =200 GeV
Dihadron and isolated direct photon-hadron angular correlations are measured in p+p collisions at s=200 GeV. The correlations are sensitive to nonperturbative initial-state and final-state transverse momenta kT and jT in the azimuthal nearly back-to-back region Δφ∼π. To have sensitivity to small transverse momentum scales, nonperturbative momentum widths of pout, the out-of-plane transverse-moment
Helping older adults : Environmental modifications of the capable program
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Clinical Experience of Overnight Use of a Temperature-controlled Airflow Device in a Teenager with Severe Atopic Dermatitis
PageRank's Ability to Track Webpage Quality: Reconciling Google’s Wisdom-of-Crowds Justification with the Scale-free Structure of the Web
We address the fundamental question why we should use PageRank and similar link-based algorithms in search engines, if at all. In a legendary article from 1998, the Google founders gave an intriguing wisdom-of-crowds justification for PageRank according to which the latter tracks quality online. This striking suggestion stands in contrast to the view that PageRank merely tracks what is popular. Ho
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Human adipose glycerol flux is regulated by a pH gate in AQP10
Obesity is a major threat to global health and metabolically associated with glycerol homeostasis. Here we demonstrate that in human adipocytes, the decreased pH observed during lipolysis (fat burning) correlates with increased glycerol release and stimulation of aquaglyceroporin AQP10. The crystal structure of human AQP10 determined at 2.3 Å resolution unveils the molecular basis for pH modulatio
Relations between implementation of new treatments and improved outcomes in patients with non-ST-elevation myocardial infarction during the last 20 years : experiences from SWEDEHEART registry 1995 to 2014
Aims: We assessed the changes in short- and long-term outcomes and their relation to implementation of new evidence-based treatments in all patients with non-ST-elevation myocardial infarction (NSTEMI) in Sweden over 20 years. Methods and results: Cases with NSTEMI (n = 205 693) between 1995 and 2014 were included from the nationwide Swedish Web-System for Enhancement and Development of Evidence-B
Simulation of magnetised microstructure evolution based on a micromagnetics-inspired FE framework : application to magnetic shape memory behaviour
Microstructure evolution in magnetic materials is typically a non-local effect, in the sense that the behaviour at a material point depends on the magnetostatic energy stored within the demagnetisation field in the entire domain. To account for this, we propose a finite element framework in which the internal state variables parameterising the magnetic and crystallographic microstructure are treat
The interplay between immune response and bacterial infection in COPD : Focus Upon non-typeable Haemophilus influenzae
Chronic obstructive pulmonary disease (COPD) is a debilitating respiratory disease and one of the leading causes of morbidity and mortality worldwide. It is characterized by persistent respiratory symptoms and airflow limitation due to abnormalities in the lower airway following consistent exposure to noxious particles or gases. Acute exacerbations of COPD (AECOPD) are characterized by increased c
A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
Immunophenotypic characterization and molecular analysis have long been used to delineate heterogeneity and define distinct cell populations. FACS is inherently a single-cell assay, however prior to molecular analysis, the target cells are often prospectively isolated in bulk, thereby losing single-cell resolution. Single-cell gene expression analysis provides a means to understand molecular diffe