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Islet autoimmunity in type 1 diabetes results in the loss of the pancreatic β-cells. The consequences of insulin deficiency in the portal vein for liver fat are poorly understood. Under normal conditions, the portal vein provides 75% of the liver blood supply. Recent studies suggest that non-alcoholic fatty liver disease (NAFLD) may be more common in type 1 diabetes than previously thought, and ma

We investigated possible motivations for sound symbolism in spatial demonstratives within 101 areally and genetically diverse languages. Six different predictions were formulated on the basis of factors such as (a) semiotic ground (iconic, indexical or combined), (b) speaker-centered, hearer-centered or both and (c) applicable to vowels, consonants or both. Each one of these six predictions result

The efficacy of intraportal (i.p.) nor-epinephrine infusion in controlling bleeding upon liver trauma in the presence of normal as well as defective platelet function was evaluated in the rat. Infusion of nor-epinephrine (10-4 M, NE) took place after cannulation of the gastro-duodenal vein, during 5 min prior to liver trauma. Simultaneously blood pressure (BP) was registered. Platelet aggregation

Context: Both leukocyte telomere length and IGF-I are associated with the aging process. A previous in vitro study suggested that IGF-I may modulate telomerase activity in white blood cells, but little is known whether these two systems interact in vivo. Patients and Methods: Leukocyte telomere length was determined using a quantitative PCR assay in 2744 elderly men (mean age 75.5 yr, range 69-81

The article presents the main results of a joint investigation by Swedish researchers and industry representatives carried out during 2006-2007 concerning the benefits of modern object based information and communication technology, ICT, for industrialisation of the building industry. The background for the investigation was an experience by both parties of a lack of coherence between scientific r

The main purpose of this study was to investigate whether the outcome obtained at the end of a work rehabilitation programme for people with various disabilities were stable in a one-year perspective. An additional aim was to explore which factors influenced the outcome upon completion of work rehabilitation and at the one-year follow-up. The study used information from a database and comprised 29

Our knowledge of the molecular mechanisms of urinary tract infection (UTI) pathogenesis has advanced greatly in recent years. In this review, we provide a general background of UTI pathogenesis, followed by an update on the mechanisms of UTI susceptibility, with a particular focus on genetic variation affecting innate immunity. The innate immune response of the host is critically important in the