Immune thrombocytopenia (ITP) is a bleeding disorder characterized by antibody-opsonized platelets being prematurely destroyed in the spleen, although some patients with ITP may have a cell-mediated form of thrombocytopenia. Although several animal models of ITP have been developed, few mimic primary chronic ITP nor have any shown cell-mediated platelet destruction. To create this type of model, s

Companies are constantly being pressured to innovate in order to stay competitive in the short run and have new offerings in the long run. One way of boosting innovation is to develop idea support systems that go beyond the traditional methods and tools. Through a qualitative study, this paper explores the lessons learned from developing an online platform for idea generation, and discusses it in

In this paper the linearized equations of motion in multibody dynamics are derived. Explicit expressions for the coefficient matrices are presented and given their physical interpretations. The equations of motion are presented in terms of the mechanical stiffness, its adjoint and the associated differential operators. It is demonstrated how the adjoint matrix may be used to find solutions to the

We propose a functional version of the Hodrick–Prescott filter for functional data which take values in an in nite-dimensional separable Hilbert space. We further characterize the associated optimal smooth- ing operator when the associated linear operator is compact and the underlying distribution of the data is Gaussian.

A helicopter flying through an atmosphere containing particulates may accumulate high electrostatic charges which can challenge its operational safety. In this paper we elaborate and validate a triboelectric charging model to predict the electrification experienced by a helicopter while hovering in dusty air. We employed Large Eddy simulations to describe the turbulent structures inherent in the f

We derive process limit distribution results for the Nelson–Aalen estimator of a hazard function and for the Kaplan–Meier estimator of a distribution function, under different dependence assumptions. The data are assumed to be right censored observations of a stationary time series. We treat weakly dependent as well as long range dependent data, and allow for qualitative differences in the depende

A compression-molded green composite material comprising of bacterially synthesized poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) [P(3HB-co-3HHx)] and short kenaf fibers (KF) was prepared in the present study. Accordingly, P(3HB-co-3HHx) was produced by the Cupriavidus necator Re2058/pCB113 using the palm oil as the sole carbon source, while the polyhydroxyalkanoate (PHA) copolymer with ∼99% purit

Transfusion-related acute lung injury (TRALI) is a serious complication of transfusion and has been ranked as one of the leading causes of transfusion-related fatalities. Nonetheless, many details of the immunopathogenesis of TRALI, particularly with respect to recipient factors are unknown. We used a murine model of antibody-mediated TRALI in an attempt to understand the role that recipient lymph

The class N∞ κ consists of all generalized Nevanlinna functions N with κ negative squares for which the root space at ∞ of the self-adjoint relation in the minimal model (short for self-adjoint operator realization) of N contains a κ-dimensional non-positive subspace. In this paper we discuss two specific models for the function N ∈ N∞ κ: one associated with the irreducible representation of N and

Hidden Markov models are often used to model daily returns and to infer the hidden state of financial markets. Previous studies have found that the estimated models change over time, but the implications of the time-varying behavior have not been thoroughly examined. This paper presents an adaptive estimation approach that allows for the parameters of the estimated models to be time varying. It is

Accumulation of intraneuronal inclusions, containing mainly a protein called alpha-synuclein (asyn), is thought to play a critical role in neurodegenerative disorders such as Parkinson's disease (PD). In these so called Lewy bodies, the majority of asyn is phosphorylated at serine 129 (pS129) suggesting that post-translational modifications may play a critical role in the process of aggregate form

Basophils are emerging as immunoregulatory cells capable of interacting with their environment not only via their characteristic IgE-mediated activation, but also in an IgE-independent manner. Basophils are known to express and respond to stimulation via TLR2, TLR4, DC-SIGN and DCIR, but whether basophils also express other C-type lectin receptors (CLRs) is largely unknown. In this study, we inves

A mechanical failure of a single component is sufficient to cause a solid oxide fuel cell (SOFC) breakdown. As an unfavorable issue for interfering the stable operation of SOFCs, thermal stress stemming from temperature gradient and mechanical mismatch can result in crack damage. Therefore, it is strongly significant to clarify the relationship of mechanical properties of the cell materials with dA mechanical failure of a single component is sufficient to cause a solid oxide fuel cell (SOFC) breakdown. As an unfavorable issue for interfering the stable operation of SOFCs, thermal stress stemming from temperature gradient and mechanical mismatch can result in crack damage. Therefore, it is strongly significant to clarify the relationship of mechanical properties of the cell materials with d