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Aims Preliminary studies suggest that direct stenting (DS) during percutaneous coronary intervention (PCI) may reduce microvascular obstruction and improve clinical outcome. Thrombus aspiration may facilitate DS. We assessed the impact of DS on clinical outcome and myocardial reperfusion and its interaction with thrombus aspiration among ST-segment elevation myocardial infarction (STEMI) patients
The rich vacuum structure of multi-Higgs extensions of the Standard Model (SM) may have interesting cosmological implications for the electroweak phase transition (EWPT). As an important example of such class of models, we consider a particularly simple low-energy SM-like limit of a recently proposed Grand-Unified Trinification model with the scalar sector composed of two Higgs doublets and a comp
Motility-induced phase separation leads to cohesive active matter in the absence of cohesive forces. We present, extend and illustrate a recent generalized thermodynamic formalism which accounts for its binodal curve. Using this formalism, we identify both a generalized surface tension, that controls finite-size corrections to coexisting densities, and generalized forces, that can be used to const
Objective: The aim was to compare the vitamin D levels in patients with Graves disease (GD) with the general population and to correlate the vitamin D levels with laboratory and clinical parameters in GD. Moreover, we examined the genetic variation in genes involved in the vitamin D metabolism and their association with GD.Methods: The levels of vitamin D were compared in 292 patients with newly d
Background: The Ca2+ binding apoptosis-linked gene-2 (ALG-2) protein acts as a proapoptotic factor in a variety of cell lines and is required either downstream or independently of caspases for apoptosis to occur. ALG-2 belongs to the penta-EF-hand (PEF) protein family and has two high-affinity and one low-affinity Ca2+ binding sites. Like other PEF proteins, its N terminus contains a Gly/Pro-rich
The penta-EF hand (PEF) family of calcium binding proteins includes grancalcin, peflin, sorcin, calpain large and small subunits as well as ALG-2. Systematic testing of the heterodimerization abilities of the PEF proteins using the yeast two-hybrid and glutathione S-transferase pull-down assays revealed the new finding that grancalcin interacts strongly with sorcin. In addition, sorcin and grancal
Hur vet vi vad som är rätt och fel i en situation? Och hur avgör vi hur vi ska handla? Lagar är tydligt nedskrivna och det finns föreskrivna sanktioner om man bryter mot lagen. Men så tydligt är inte vårt samhälle. När vi är laglydiga utan att känna till lagen följer vi egentligen normer. Vårt handlande styrs sällan enbart av lagar och regler utan av dessa, oskrivna och osynliga, normer.Normer och
In type 2 diabetes (T2D), hepatic insulin resistance is strongly associated with nonalcoholic fatty liver disease (NAFLD). In this study, we hypothesized that the DNA methylome of livers from patients with T2D compared with livers of individuals with normal plasma glucose levels can unveil some mechanism of hepatic insulin resistance that could link to NAFLD. Using DNA methylome and transcriptome
Several studies have proposed that small- and medium-sized enterprises (SMEs) lack resources and experiential knowledge to internationalise to distant markets. The authors argue that SMEs can handle the lack of these tangible and intangible internal resources through external collaborations; they can achieve success in international markets by collaborating with business partners. The role of inte
BACKGROUND: The addition of high-dose cytarabine to the treatment of mantle cell lymphoma (MCL) has significantly prolonged survival of patients, but relapses are common and are normally associated with increased resistance. To elucidate the mechanisms responsible for cytarabine resistance, and to create a tool for drug discovery investigations, we established a unique and molecularly reproducible
Development of antibody drugs against novel targets and pathways offers great opportunities to improve current cancer treatment. We here describe a phenotypic discovery platform enabling efficient identification of therapeutic antibody-target combinations. The platform utilizes primary patient cells throughout the discovery process and includes methods for differential phage display cell panning,
In recent years, subsets of chronic lymphocytic leukemia (CLL) patients carrying quasi-identical or stereotyped B cell receptors (BcRs) have been identified that share clinicobiological features and disease outcome. While these stereotyped subsets show distinct gene expression and genomic profiles, the DNA methylation landscape remains largely unexplored. By applying high-resolution 450K methylati
We report the transverse single-spin asymmetries of J/ψ production at forward and backward rapidity, 1.2
A search for flavour-changing neutral-current processes in top-quark decays is presented. Data collected with the ATLAS detector from proton-proton collisions at the Large Hadron Collider at a centre-of-mass energy of s=13 TeV, corresponding to an integrated luminosity of 36.1 fb−1, are analysed. The search is performed using top-quark pair events, with one top quark decaying through the t → qZ (q
Measurements are made of differential cross-sections of highly boosted pair-produced top quarks as a function of top-quark and tt. system kinematic observables using proton-proton collisions at a center-of-mass energy of s=13 TeV. The data set corresponds to an integrated luminosity of 36.1 fb-1, recorded in 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. Events with two l
The AAAI 2017 Fall Symposium Series was held Thursday through Saturday, November 9–11, at the Westin Arlington Gateway in Arlington, Virginia, adjacent to Washington, DC. The titles of the six symposia were Artificial Intelligence for Human-Robot Interaction; Cognitive Assistance in Government and Public Sector Applications; Deep Models and Artificial Intelligence for Military Applications: Potent
Communication and collaboration is a major challenge for large-scale software development. Cognitive and psychological distance between individuals and teams affect this collaboration and can cause communications gaps. We propose a novel method for assessing distance between teams, and explore potential explanations for these distances. In an exploratory case study of the quality assurance departm
We trace the development of neo-institutional theory in Organization Studies from a marginal topic to the dominant theory. We show how it has evolved from infancy, through adolescence and early adulthood to being a fully mature theory, which we think is now facing a mid-life crisis. Some of the features of this mid-life crisis include over-reach, myopia, tautology, pseudo-progress and re-inventing
Continuous Software Engineering (CSE) - -continuous development and deployment of software - -and DevOps - -the close cooperation or integration of operations and software development - -is about to change how software is developed. Together with the tighter integration of development and operations also with usage this will change coordination and collaboration both between IT professionals and b
