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Two forms of glutamic-acid decarboxylase (GAD) have been identified in mammalian tissues: a 65-kDa form (GAD65) and a 67-kDa form (GAD67). Alternate splicing produces one or two smaller variants of GAD67 in the brain of embryonic mice and rats. Additionally, a short, heretofore unidentified transcript homologous to GAD67 has been detected in human testis RNA. Because GAD, the enzyme responsible fo
Because the development of insulitis and diabetes is predictable in Lyp/Lyp congenic BB rats, we have characterized early islet inflammation in these rats to determine the cell subsets involved in the onset of autoimmune insulitis. Pancreas sections from prediabetic Lyp/Lyp, Lyp/+ and +/+ rats were analyzed by immunohistochemistry. We found W3/25+ cells in the exo- and endocrine tissue from all th
A quantitative assay with microSepharose was used to determine GAD65Ab and IA-2Ab levels in 771 population-based patients diagnosed with diabetes mellitus at 15 to 34 years of age, and in 828 matched controls. Among the patients, 587 (76%) were classified with type I, 108 (14%) with type II, and 76 (10%) with unclassifiable diabetes. The levels above normal demonstrated a prevalence of GAD65Ab in
Eco-labelled seafood is an important tool to promote sustainable development in fisheries. A price premium on eco-labelled seafood signals a return on investment in sustainable fishing methods, providing an incentive for fishers to adopt such methods. This paper investigates whether Swedish fishermen gained a price premium from participating in the Marine Stewardship Council (MSC)-certified Swedis
Many students who enter college are insufficiently prepared to follow a demanding college-level curriculum. Thus, higher education institutions often require low-performing students to repeat failed courses, a full term, or even a full year. This paper is the first to investigate the effects of such a “(grade) retention” policy on student performance in higher education. We study a setting where f
Does the provision of after-school care promote maternal employment and thus help to foster gender equality in labor supply? We address this question by exploiting variation in cantonal (state) regulations of after-school care provision in Switzerland. To establish exogeneity of cantonal regulations with respect to employment opportunities and preferences of the population, we restrict our analysi
Disability insurance (DI) beneficiaries lose part or all of their benefits if earnings exceed certain thresholds (“cash-cliffs”). This implicit taxation is considered the prime reason for the low number of beneficiaries who expand work and reduce benefit receipt. We analyse a conditional cash programme that incentivises work related reductions of disability benefits in Switzerland. Four thousand D
Listen. If I ask you to listen, what is it that I ask of you—that you will understand, or perhaps obey? Or is it some sort of readiness that is requested? What occurs with a body in the act of listening? How do sound and voice structure audio-visual-spatial relations in concrete situations? This doctoral thesis in fine arts consists of six artworks and an essay that documents the research process
En berättelse om organisering blandar fiktion med organisationsteorins grunder. Boken drivs framåt av vad som händer på det nystartade modeföretaget Mess. Genom skildringen av Mess och människorna i och runt omkring företaget ser vi framgångar, konflikter och utmaningar i organisationsteorins ljus.Mötet mellan den fiktiva berättelsen och de teoretiska fördjupningarna ger grundläggande förståelse f
Fiskeriavtal med Europeiska unionen är en stor inkomstkälla för vissa utvecklingsländer. Intäkterna från att utländska flottor tillåts fiska på ens territorium kan ligga på 30–50 procent av statsbudgeten.I den här rapporten analyserar författarna Johan Blomquist, Cecilia Hammarlund och Staffan Waldo – samtliga verksamma vid AgriFood Economics Centre – effekterna av EU:s fiskeriavtal med länder i
The MAX IV facility in Lund, Sweden, consists of two storage rings for production of synchrotron radiation, and a full-energy LINAC for top-up injections. The LINAC also delivers short high-intensity electron bunches to a short pulse facility. MAX IV was inaugurated in June 2016, and the larger 3 GeV ring has been delivering light to users since November 2016. In this thesis, the design and implem
People, places, and production contributing the least to climate change will suffer the most. This calls for adaptation as a key climate change response. But adaptation is surrounded by problems. Finance is uncertain and fragmented, mainstreaming into development is complicated, and technical solutions often overshadow existing social relations and institutions. From a gender perspective, and as a
The literature on employee spinoffs has, for a long time, stressed the importance of industry-specific skills and experiences in explaining the success of new firms. We argue that employees also develop skills that are associated with their occupation within an industry, and that success as an entrepreneur, therefore, is also contingent on the relation between the entrepreneurs’ previous occupatio
Alien crosstalk is one of the major impairments for copper-based transmissions. This letter outlines a method for mitigating alien crosstalk for DSL downstream transmissions impaired by multiple interference sources. The method requires a reference channel, and includes a post processing stage in which induced correlation is applied to prepare the interference at the target channel to be reasonabl
