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Neck-bridge device for combined endovascular and surgical treatment of a giant anterior communicating artery aneurysm

We report the case of a 58-year-old man with a giant partially thrombosed anterior communicating artery aneurysm, which presented with mass effect. Our treatment strategy consisted of endovascular aneurysm circulatory exclusion prior to surgical resection. To do so, we first occluded both the two A1 segments and the aneurysm neck with a neck-bridge device to prevent further coil migration within t

Genetic polymorphism of chemokine receptors CCR2 and CCR5 in Swedish cervical cancer patients

Chemokines are chemotactic cytokines that orchestrate leukocyte trafficking in tissues, thus, playing an important role in regulation of immunological processes. The aim of this study was to investigate the association of human papillomavirus (HPV) infection and cervical cancer with two DNA polymorphisms of the chemokine receptors CCR5-Delta 32 and CCR2-64L The study material consisted of 50 cervi

Improved affinity coupling for antibody microarrays: Engineering of double-(His)(6)-tagged single framework recombinant antibody fragments

Antibody-based microarray is a novel technology with great promise in biomedicine that will provide unique means to perform global proteome analysis. In the process of designing the high-density antibody microarrays required, several critical key issues have been identified that remain to be resolved. In particular, there is a great need for specific and selective approaches enabling non-purified

A Functional Variant in the {alpha}2B Adrenoceptor Gene, a Positional Candidate on Chromosome 2, Associates With Hypertension.

In a genome-wide scan in Scandinavians, we found suggestive linkage between early-onset primary hypertension and a region on chromosome 2. The 2B-adrenoceptor gene, a candidate gene within this region, harbors a functional insertion/deletion (I/D) polymorphism of three glutamate residues. The aim of this study was to investigate if the DD genotype is associated with hypertension in Swedes. We perf

ELTs, adaptive optics and wavelengths - art. no. 698608

A number of Extremely Large Telescopes for visual-infrared and adjacent wavelengths are in various degrees of progress. All have primary mirrors with equivalent diameters larger than 20 m and are intended for operation with adaptive optics systems. We discuss several ELT observing parameters as functions of wavelength. Stellar energy distributions and atomic line spectra are inspected as are the t

Use of surface active additives in enzymatic hydrolysis of wheat straw lignocellulose

Monocot residues such as corn stover and straw are often not fully exploited and constitute a potential substrate for bioethanol production. However, a number of factors such as high enzyme loadings make large-scale utilization economically difficult. Addition of non-ionic surfactants and poly(ethylene glycol) to enzymatic hydrolysis of various lignocellulosic substrates has been found to increase

A 6-year follow-up of dosing, coagulation factor levels and bleedings in relation to joint status in the prophylactic treatment of haemophilia

The primary aim of this study was to investigate the possible relationship between coagulation factor level and bleeding frequency during prophylactic treatment of haemophilia after stratification of the patients according to joint scores. The secondary aim was to obtain a systematic overview of the doses of coagulation factors prescribed for prophylaxis at the Malmo haemophilia treatment centre d

Near- and Deep-Ultraviolet Resonance Raman Spectroscopy of Pyrazine-Al-4 Complex and Al-3-Pyrazine-Al-3 Junction

Near- and deep-ultraviolet (UV) resonance Raman spectroscopy of pyrazine-Al-4 complex and Al-3-pyrazine-Al-3 junction was investigated theoretically with a quantum chemical method. Here, 325 and 244 nm were employed as near- and deep-UV sources in our theoretical study The intensities of static normal Raman spectra of pyrazine-Al-4 complex and Al-3-pyrazine-Al-3 junction were enhanced oil the orde

Dopamine neurons grafted unilaterally to the nucleus accumbens affect drug-induced circling and locomotion

The purpose of the present study was to investigate the amplifying function of the nucleus accumbens septi region (NAS) in 6-hydroxydopamine (6-OHDA)-induced rotational behaviour by implanting fetal dopamine (DA)-rich mesencephalic cell suspensions unilaterally in the NAS of rats previously subjected to combined mesostriatal (MS) and NAS 6-OHDA lesions. First, all the rats received a unilateral 6-

Dose and plasma concentration of galantamine in Alzheimer's disease - clinical application

Introduction: Patients with Alzheimer's disease (AD) are currently treated with cholinesterase inhibitors, such as galantamine, without actual knowledge of its concentration in plasma. Our objective was to analyse potential relationships between galantamine concentration, galantamine dose, socio-demographic characteristics, body weight, body mass index (BMI), and treatment response. Methods: Eight

The History, Development, and Realisation of Medical Radiation Physics Education in Sweden

This paper describes the history of Swedish medical radiation physics education and gives details of the core curriculum of today’s 5-year specialised medical radiation physicist programme, which fulfils the need to educate clinical physicists with versatile basic knowledge and skills who are well prepared for professional life in all sub-areas of medical radiation physics and radiation protection

Output feedback distributed model predictive control with inherent robustness properties

We consider robust output feedback distributed model predictive control (DMPC). The proposed controller is based on the results in [8] in which nominal stability and feasibility was proven for a DMPC-formulation without terminal constraint set or terminal cost in the optimization. We extend these results to show robust stability under state feedback as well as output feedback when dynamics and mea

Voronoi-based three-dimensional polygonal finite elements for electromechanical problems

Abstract in UndeterminedWe discuss the combination of a hybrid finite element approach and three-dimensional Voronoi-based mesh discretisations for electromechanically coupled problems. The fluxes, i.e. the stresses and electric displacements, are defined within the volume of the polygonal finite elements, whereas the displacements and electric potential are approximated on the boundaries of the e

Improvement of cognitive functions after cobalamin/folate supplementation in elderly patients with dementia and elevated plasma homocysteine

OBJECTIVES: To investigate the effect of cobalamin/folate supplementation on cognitive function in elderly patients with dementia. METHOD: The cobalamin/folate status of the patients was evaluated by measuring plasma homocysteine, serum methylmalonic acid, serum cobalamin and blood folate. Thirty-three patients were studied and repeatedly assessed with the Mini-Mental State Examination (MMSE) and

Clinical value of human glandular kallikrein 2 and free and total prostate-specific antigen in serum from a population of men with prostate-specific antigen levels 3.0 ng/mL or greater

OBJECTIVES: To investigate the clinical value of human glandular kallikrein 2 (hK2) compared with free (f) and total (t) prostate-specific antigen (PSA) in the early detection of prostate cancer (PCa). METHODS: In PCa screening conducted in 1995 to 1996 in Goteborg, Sweden, 5853 of 9811 randomly selected men (aged 50 to 66 years; median 61) accepted PSA testing; those with tPSA levels of 3. 0 ng/m