In Europe, individualist societies, in which people more highly value independence, have fewer people who are lonely. Yet these societies also have more people who live alone, a strong determinant of loneliness. Evidence suggests that some unrecognized societal-level resources or characteristics can explain this.We uncover multiple pathways toward a lower degree of loneliness among European societ

UNLABELLED: Isocitrate dehydrogenase 1 and 2 (IDH) are mutated in multiple cancers and drive production of (R)-2-hydroxyglutarate (2HG). We identified a lipid synthesis enzyme [acetyl CoA carboxylase 1 (ACC1)] as a synthetic lethal target in mutant IDH1 (mIDH1), but not mIDH2, cancers. Here, we analyzed the metabolome of primary acute myeloid leukemia (AML) blasts and identified an mIDH1-specific

Therapeutic cancer vaccination seeks to elicit activation of tumor-reactive T cells capable of recognizing tumor-associated antigens (TAAs) and eradicating malignant cells. Here, we present a cancer vaccination approach utilizing myeloid lineage reprogramming to directly convert cancer cells into tumor reprogrammed-antigen presenting cells (TR-APCs). Using syngeneic murine leukemia models, we demo

To chemically modulate the ubiquitin-proteasome system for degradation of specific target proteins is currently emerging as an alternative therapeutic modality. Earlier we discovered such properties of the stem cell-supporting small molecule UM171 and identified that members of the CoREST complex (RCOR1 and LSD1) are targeted for degradation. UM171 supports the in vitro propagation of hematopoieti

Wetlands are facing gradual drying, leading to large carbon loss due to the transformation from anaerobic to aerobic conditions, but the temperature and drought effects from the temperature and moisture fluctuation on soil organic carbon (SOC) mineralization remain uncertain. An incubation study with three moisture levels (100%, 60%, and 40% WHC, marked as W100, W60, and W40, respectively) and fou

We use the superfluid tunneling model (STM) to calculate the half-lives of α decays of odd-A and odd-odd superheavy nuclei (SHN) with Z≥100 and A≥250. The experimental data are reproduced to accuracies comparable to other contemporary models of the α decay of the SHN. We then apply the STM to examine the influence of the quasiparticle structure on the properties of the chains of α decays arising f

Introduction: There are multiple contributors to falls in older adults. Both health-related (poor balance, polypharmacy, and poor vision), and home-related (home hazards). However, most fall risk interventions only address one or two. The successful Lifestyle Intervention Functional Exercise (LiFE) program could likely be developed into a multicomponent intervention. Objectives: The objectives wer

ABSTRACT:Introduction / Rationale: From the onset of the COVID-19 pandemic, social distancing was recommended for adults 70 years and older (70+) in Sweden. From an outside view, they then became deprived of possibilities to engage in meaningful activities. However, as meaning is highly subjective, we need to listen to older adults’ voices to really know.Objectives: To explore how adults 70+ exper

Havs- och vattenmyndigheten har föreslagit att svenskt demersalt fiske (fiske efter bottennära arter som räka, kräfta, torsk) ska regleras med överlåtbara fiskerättigheter. En förväntad effekt av detta är en koncentration av fisket till färre men större företag. Illustrativa exempel från isländskt fiske och det svenska pelagiska fisket (sill, skarpsill, makrill) som förvaltas med liknande system v

By being predicated on supervised machine learning, pattern recognition approaches to myoelectric prosthesis control require electromyography (EMG) training data collected concurrently with every detectable motion. Within this framework, calibration protocols for simultaneous control of multifunctional prosthetic hands rapidly become prohibitively long - the number of unique motions grows geometri

Which images are made manifest across an artist’s practice and which are the ones that disappear? How do objects—whether seen or unseen—and the knowledge they possess traverse across place and time to avow their resistance? These are amongst the questions asked by artist Nour Bishouty in her artist’s book 1—130, a project that draws upon her ongoing research into the works of her father, Ghassan B

Strata compiles 37 conversations with artists whose work has made a significant contribution to the Italian and international art scene since 2000. This book is the personal account of a number of encounters, friendships, and professional relationships that Vincenzo de Bellis and Alessandro Rabottini have nurtured over the past twenty years. The conversations explore pivotal moments in each artist

This paper demonstrates a wideband 2.4 GHz $2\times 9$ -bit Cartesian radio-frequency digital-to-analog converter (RFDAC). Active-under-coil integration is introduced in the physical implementation, where all key active circuitry is located underneath the matching-network transformer, achieving a core area of merely 0.35 mm2. An 8× analog linear interpolation at the RF rate is proposed to suppress

This publication accompanies the exhibition of the same title co-produced by MACBA Museu d’Art Contemporani de Barcelona and Sharjah Art Foundation of the United Arab Emirates. The book brings together projects that this French-Moroccan artist has produced over the last ten years, among them films, video installations, photographs and documentary material. The publication also includes documentati

The harmonic oscillator is a truly irreplaceable as well as ubiquitous analog integrated circuit. Starting from the basics of its CMOS implementation, we will discuss the phase noise of the harmonic oscillator in some detail, where the intrinsic large-signal operation mandates a time-variant analysis. This will be followed by a survey of the most popular design techniques enabling a low phase nois

This special section of the IEEE OPEN JOURNAL OF CIRCUITS AND SYSTEMS (OJCAS) is dedicated to highlight the state-of-the-art research progress on circuits, systems, and algorithms associated with the design of beyond 5G (B5G) and 6G wireless systems.

We present the application of two fibre-optic-coupled time-resolved spectrofluorometers and a compact steady-state diffuse reflected light/fluorescence spectrometer to in vivo and ex vivo studies of skin cancer and osteoarthritis. In a clinical study of skin cancer, 27 lesions on 25 patients were investigated in vivo before surgical excision of the region measured. Preliminary analysis reveals a s