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Towards successful industrial policy on AI in healthcare : establishing the conditions for future public benefit

This paper explores how pro-active government policies could promote artificial intelligence (AI) in healthcare for the public good. Building on insights from the literature on industrial policy, we argue that without clear conditions and guardrails to ensure future public benefit, state assistance and subsidies will be nothing more than corporate welfare with unpredictable, if any, societal benef

Applications of X-ray fluorescence microscopy with synchrotron radiation : From biology to materials science

X-ray fluorescence emission spectroscopy is a powerful tool to gain chemical information on a wide variety of samples. Its combination with focused X-ray beams and translation stages enables X-ray fluorescence microscopy, generating quantitative distribution maps for sets of chemical elements, depending on incident photon energy and detector specifications. The use of synchrotron radiation for X-r

Psychological distress is associated with pain and symptom severity in patients with longstanding hip and groin pain : A cross-sectional study

Background: The primary aim was to assess psychological distress in patients with longstanding hip and groin pain (LHGP) and compare them with healthy controls. The secondary aim was to explore the association between psychological distress and symptom duration, self-reported pain and symptoms in patients with LHGP. Methods: Seventy-two patients with LHGP and sixty-three controls were included. Th

Kondo spectral functions at low-temperatures : A dynamical-exchange-correlation-field perspective

We calculate the low-temperature spectral function of the symmetric single impurity Anderson model using a recently proposed dynamical exchange-correlation (xc) field formalism. The xc field, coupled to the one-particle Green’s function, is obtained through analytic analysis and numerical extrapolation based on finite clusters. In the Kondo regime, the xc field is modeled by an Ansatz that takes i

Development of serious mental illness in young adult violent offenders : Early-life risk factors and long-term adverse outcomes

This study explored serious mental illness (SMI) in young adult offenders imprisoned for violent or sexual crimes, estimating the effects of neurodevelopmental disorders and early-life risk factors on the development of SMI, and its prospective long-term adverse outcomes. An all-male cohort of 266 violent offenders, assessed during imprisonment when aged 18–25 years (M = 21.8, SD = 1.9), was follo

Enhanced characterization of non-metallic inclusions in ultra-high-strength steels using advanced synchrotron-based X-ray absorption spectroscopy and chemometric analysis

This study leverages synchrotron radiation-based X-ray absorption photoemission electron microscopy (X-PEEM) to investigate non-metallic inclusions (NMIs) in ultra-high-strength steels. By acquiring Ca-L2,3-edge X-ray absorption spectra from six NMIs at both room temperature and 400 °C, we analyze their structural changes, chemical compositions, and phase transformations. To extract meaningful ins

Participation of COX2/mPGES1/PGE2 in mouse and human endometrial stromal decidualization

Background: Prostaglandin E2 (PGE2) is vital for embryo implantation and decidualization. Whether COX2/mPGES1/PGE2 pathway is essential for mouse and human decidualization remains unclear. Results: This study showed that mPGES1 was highly expressed in the mouse uterus’s subluminal stromal cells at the implantation site. COX2-specific inhibitor Valdecoxib and mPGES1 selective inhibitor MK886 were u

A novel implementation of pre-processing approaches and hybrid kernel-based model for short- and long-term groundwater drought forecasting

Groundwater drought, as a form of hydrological drought, embodies the distinctive characteristics of the aquifer and human-induced disruptions within the hydrological system. The intricate nature of groundwater flow systems, coupled with challenges in acquiring field observations related to aquifers, poses significant challenges in quantitatively characterizing groundwater drought. The present pape

The relevance of employing a three-perspective view on occupational balance among people with depression and/or anxiety disorders

BACKGROUND: Assessing perceptions of occupational balance is essential in both clinical occupational therapy and research. Attempts to characterise occupational balance often arrive at multi-faceted explanations, including a variety of occupations, personal satisfaction, and time allocation.AIM: This study aimed to deepen the understanding of occupational balance as a phenomenon and investigate th

Pentastatin, a matrikine of the collagen IVα5, is a novel endogenous mediator of pulmonary endothelial dysfunction

Deposition of basement membrane components, such as collagen IVα5, is associated with altered endothelial cell function in pulmonary hypertension. Collagen IVα5 harbors a functionally active fragment within its C-terminal noncollageneous (NC1) domain, called pentastatin, whose role in pulmonary endothelial cell behavior remains unknown. Here, we demonstrate that pentastatin serves as a mediator of

Endothelial Basement Membrane Components and Their Products, Matrikines : Active Drivers of Pulmonary Hypertension?

Pulmonary arterial hypertension (PAH) is a vascular disease that is characterized by elevated pulmonary arterial pressure (PAP) due to progressive vascular remodeling. Extracellular matrix (ECM) deposition in pulmonary arteries (PA) is one of the key features of vascular remodeling. Emerging evidence indicates that the basement membrane (BM), a specialized cluster of ECM proteins underlying the en

New bio- and chemostratigraphic data from southwestern China and its relation to Telychian (Llandovery, Silurian) climate change

Integrated conodont and carbon isotope data is presented from the Telychian (upper Llandovery, lower Silurian) from the Baicaoping section, Yunnan Province, southwestern China. Three conodont zonal units, in stratigraphically ascending order, the Pterospathodus eopennatus Superzone, Pterospathodus celloni Superzone, and the Pterospathodus amorphognathoides amorphognathoides Zone, are recognized in

The basement membrane in the cross-roads between the lung and kidney

The basement membrane (BM) is a specialized layer of extracellular matrix components that plays a central role in maintaining lung and kidney functions. Although the composition of the BM is usually tissue specific, the lung and the kidney preferentially use similar BM components. Unsurprisingly, diseases with BM defects often have severe pulmonary or renal manifestations, sometimes both. Excessiv

Basement membrane remodeling controls endothelial function in idiopathic pulmonary arterial hypertension

The extracellular matrix (ECM) increasingly emerges as an active driver in several diseases, including idiopathic pulmonary arterial hypertension (IPAH). The basement membrane (BM) is a specialized class of ECM proteins. In pulmonary arteries, the BM is in close contact and direct proximity to vascular cells, including endothelial cells. So far, the role of the BM has remained underinvestigated in

Impairment of the NKT–STAT1–CXCL9 Axis Contributes to Vessel Fibrosis in Pulmonary Hypertension Caused by Lung Fibrosis

Rationale: Pulmonary hypertension (PH) is a common, severe comorbidity in interstitial lung diseases such as pulmonary fibrosis (PF), and it has limited treatment options. Excessive vascular fibrosis and inflammation are often present in PH, but the underlying mechanisms are still not well understood. Objectives: To identify a novel functional link between natural killer T (NKT) cell activation an

Effects of copepod chemical cues on intra- and extracellular toxins in two species of Dinophysis

Copepods may contribute to harmful algal bloom formation by selectively rejecting harmful cells. Additionally, copepods and the chemical cues they exude, copepodamides, have been shown to induce increased toxin production in paralytic and amnesic toxin producing microalgae. However, it is unknown if diarrhetic shellfish toxin (DST) producers such as Dinophysis respond to copepods or copepodamides

The role of tool edge geometry on material removal and surface integrity in cutting metal matrix composites

Metal matrix composites (MMCs) possess excellent material properties due to the combination of metals and reinforcing phases, yet this reduces their machinability. Numerous studies have shown that, due to the ploughing effect of the cutting tool, the edge effect can directly impact the material removal mechanism and the generation of surface integrity. However, the influence of different cutting-e

Signal-Averaged ECG in the Diagnostic Workup for Arrhythmogenic Cardiomyopathy : Insights From the Nordic ARVC Registry

BACKGROUND: The diagnostic role of signal-averaged ECG (SAECG) in arrhythmogenic right ventricular cardiomyopathy (ARVC) has lately been questioned. We assessed the value of SAECG-derived late ventricular potentials (LP) in ARVC diagnosis and its association with disease manifestations.METHODS AND RESULTS: Patients with definite ARVC diagnosis or genotype-positive family members who underwent SAEC

Conflicting identities : cosmopolitan or anxious? Appreciating concerns of host country population improves attitudes towards immigrants

This paper connects insights from the literature on cosmopolitan worldviews and the effects of perspective-taking in political science, (intergroup) anxiety in social psychology, and identity economics in a vignette-style experiment. In particular, we asked German respondents about their attitudes towards a Syrian refugee, randomizing components of his description (N = 662). The main treatment des

Design, evaluation, and in vitro–in vivo correlation of self-nanoemulsifying drug delivery systems to improve the oral absorption of exenatide

The ability to predict the absorption of exenatide (Ex), a GLP-1 analogue, after oral dosing to rats in self-nanoemulsifying drug delivery systems (SNEDDS), using in vitro methods, was assessed. Ex was complexed with soybean phosphatidylcholine (SPC) prior to loading into SNEDDS. A design of experiments (DoE) approach was employed to develop SNEDDS incorporating medium-chain triglycerides (MCT), m