A novel pH and temperature dual-responsive bioconjugate is prepared by grafting thermoresponsive polymer chains from a pH-responsive protein amelogenin via atom transfer radical polymerization. To the best of our knowledge, this is the first time that amelogenin is exploited to prepare a hybrid biomaterial with new stimuli-responsive property. In both basic and acidic solutions the protein-polymer

Nanoparticles affect the immune system as they may interact directly with immune cells and activate them. However, it is possible that nanoparticles also interact with released cytokines and immunologically active enzymes. To test this hypothesis, the activity of myeloperoxidase released from activated neutrophils was measured in the presence of nanoparticles with different chemistry and size. In

Objectives: Aerococcus urinae and Aerococcus sanguinicola cause urinary tract infections (UTIs) and antibiotic treatment recommendations are solely based on in vitro findings and limited clinical experience. Our objective was to investigate the effectiveness of different treatment strategies in aerococcal UTI through a prospective observational study. Methods: Urine samples with aerococci were ide

Den här avhandlingen handlar om luftburna designade nanopartiklar och hur mantar reda på vilka egenskaper de har. Luftburna partiklar eller aerosoler är något sommänniskan alltid har haft omkring sig. Oavsett om det varit i form av pollen, rök fråneldstaden, eller från astmainhalatorn så har de alltid varit där och påverkat oss. I varjeandetag drar vi in flera tusen partiklar, men vilken typ de ärThis thesis will explore parts of the life of engineered nanoparticles, from generation in research environments andprocess monitoring, to emissions in an industrial setting. The aim is to give insights into how the particles can becharacterized in different settings and how different characterization methods can be applied depending on need ordemand.Airborne nanoparticles have been around forever

Microfluidics is a field which has the potential to revolutionize medical diagnostics. The ability to sort and analyse cells by the use of portable handheld devices has the potential to enable sensitive devices for point-of-care diagnostics. This could play a major role in diagnosis of a wide range of diseases which are prevalent in remote areas in developing countries where a majority of the peopMicrofluidics is a field which has the potential to revolutionize medical diagnostics. The ability to sort and analyse cells by the use of portable handheld devices has the potential to enable sensitive devices for point-of-care diagnostics. This could play a major role in diagnosis of a wide range of diseases which are prevalent in remote areas in developing countries where a majority of the peop

Xenopus is a favorable experimental model in developmental biology. With its fast and external development, high number of progeny and large size, early embryos are well suited for micromanipulation to study the function of genes with relevance to human diseases. In this chapter, we present a combined method for lineage tracing and whole-mount in situ hybridization. In addition, we present protocoXenopus is a favorable experimental model in developmental biology. With its fast and external development, high number of progeny and large size, early embryos are well suited for micromanipulation to study the function of genes with relevance to human diseases. In this chapter, we present a combined method for lineage tracing and whole-mount in situ hybridization. In addition, we present protoco

Aili, C & Nilsson, L-E. (2017).

Gene-panel sequencing allows comprehensive analysis of multiple genes simultaneously and is now routinely used in clinical mutation testing of high-risk breast and ovarian cancer patients. However, only BRCA1 and BRCA2 are often analyzed also for large genomic changes. Here, we have analyzed 10 clinically relevant susceptibility genes in 95 breast or ovarian cancer patients with gene-panel sequenc

In this paper we argue for an analysis of Object Shift in Mainland Scandinavian in which the shifted word order is the result of a prosodic repair to enable weak pronoun incorporation. We observe that varieties with optional OS also have a tone accent contrast. We argue that the in-situ word order is licensed in these dialects because tonal accent creates a prosodic domain licensing the incorporat

Background An early and accurate diagnosis of chronic heart failure is a big challenge for a general practitioner. Assessment of left ventricular function is essential for the diagnosis of heart failure and the prognosis. A gold standard for identifying left ventricular function is echocardiography. Echocardiography requires input from specialized care and has a limited access in Swedish primary h

This primer introduces a series of essays on the politics of metaphors in the digital society. It aims to uncover the hidden assumptions and concepts within our discourses of the digital, piece by piece.The current rapid social and technological change is giving rise to enormousuncertainties – and a great need for explanation and sense-making. How do weunderstand the digital society? When we talk about the future that we cannot knowand a present that we do not understand, we have no option but to use the conceptual apparatus of the past – with normative, social and economic implications. This pri