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Measurement of W±W± vector-boson scattering and limits on anomalous quartic gauge couplings with the ATLAS detector MEASUREMENT of W±W± VECTOR-BOSON M. AABOUD et al.
This paper presents the extended results of measurements of W±W±jj production and limits on anomalous quartic gauge couplings using 20.3 fb-1 of proton-proton collision data at s=8 TeV recorded by the ATLAS detector at the Large Hadron Collider. Events with two leptons (e or μ) with the same electric charge and at least two jets are analyzed. Production cross sections are determined in two fiducia
Rap1 and Cdc13 have complementary roles in preventing exonucleolytic degradation of telomere 5′ ends
Telomere DNA ends with a single-stranded 3′ overhang. Long 3′ overhangs may cause aberrant DNA damage responses and accelerate telomere attrition, which is associated with cancer and aging, respectively. Genetic studies have indicated several important players in preventing 5′ end hyper-resection, yet detailed knowledge about the molecular mechanism in which they act is still lacking. Here, we use
The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation
A major hallmark of Parkinson's disease (PD) is the presence of Lewy bodies (LBs) in certain neuronal tissues. LBs are protein-rich inclusions, in which α-synuclein (α-syn) is the most abundant protein. Since these inclusions are not present in healthy individuals, despite the high concentration of α-syn in neurons, it is important to investigate whether natural control mechanisms are present to e
Molecular mechanisms of cell-cell signaling by the Spemann-Mangold organizer
Digital strategies for two-sided markets : A case study of shopping malls
Digitalization is fundamentally changing the retailing ecosystem for shopping malls as digital and analogue elements get increasingly intertwined. We conceptualize shopping malls as two-sided markets whose primary function is connecting shoppers and retailers. By means of an interpretative case study, the article then presents an omnichannel strategy typology for how shopping malls can meet the ev
A gendered approach of economic and demographic interactions : Evidence from France
This paper investigates the interaction between economic, demographic and educational variables in post-World War II France. Based on the assumptions of the unified growth theory, we estimate a vector auto-regression for data on fertility, GDP per capita, educational attainment, labor force participation and wages over the period 1962-2008. The methodology employed is based on VAR modeling, using
Conflict, consensus, and circulation : The public debates on education in Sweden, c.1800–1830
Solving Mysteries and Outwitting Transitions : Investigating the Incommensurate Crystal Structures of AuIn and Sn3Sb2
This thesis introduces two new incommensurate alloys. AuIn shows variable amounts of modulation, depending on the measurement temperature. At 400°C the diffraction pattern shows diffuse scattering and a thallium iodide type Cmcm space group. The diffuse scattering condenses into first order satellites on cooling to 300°C and the space group transforms to the incommensurate C-1(α, β, γ)0. I.e. the
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A hidden cost of migration? Innate immune function versus antioxidant defense
Migration is energetically demanding and physiologically challenging. Migrating birds, for example, need to boost their antioxidant defenses to defeat the pro-oxidants produced during high energetic activity. The enhanced antioxidant defense possibly withdraws limited resources (e.g., energy or micronutrients) from other physiological functions, such as immune defense. Such a trade-off might not o
Comprehensive on-line two-dimensional liquid chromatography × supercritical fluid chromatography with trapping column-assisted modulation for depolymerised lignin analysis
Lignin depolymerisation produces a large variety of low molecular weight phenolic compounds that can be upgraded to value-added chemicals. Detailed analysis of these complex depolymerisation mixtures is, however, hampered by the lack of resolving power of traditional analysis techniques. In this study, a novel online comprehensive two-dimensional reversed-phase liquid chromatography (RPLC) × super
Linking multiscale deformation to microstructure in cortical bone using in situ loading, digital image correlation and synchrotron X-ray scattering
The incidence of fragility fractures is expected to increase in the near future due to an aging population. Therefore, improved tools for fracture prediction are required to treat and prevent these injuries efficiently. For such tools to succeed, a better understanding of the deformation mechanisms in bone over different length scales is needed. In this study, an experimental setup including mecha
Rethinking IS Strategic Alignment : A Middle Management Perspective
IS strategic alignment remains a research phenomenon of key interest, specifically regarding the dimensions of social IS alignment (i.e., shared IS understanding among key organizational members) and intellectual IS alignment (i.e., IS/business strategy congruence). The examination of IS alignment has been predominantly limited to the examination of top ranks within the organization; however, we c
Computationally-efficient modeling of inelastic single crystal responses via anisotropic yield surfaces : Applications to shape memory alloys
Phenomenological constitutive models of inelastic responses based on the methods of classical plasticity provide several advantages, especially in terms of computational efficiency. For this reason, they are attractive for the analysis of complex boundary value problems comprising large computational domains. However, for the analysis of problems dominated by single crystal behavior (e.g., inclusi
Normative Distortions in Labour Law : Exploring the Field of Parental Rights in Working Life
This article identifies, conceptualizes and analyses a normative conflict, embedded in social practises and conceptions on gender in the institutional framework of the market, which underlies labour law regulation as well as legal argumentation regarding working parents. The article evinces and models the basic structure of vital mechanisms operative in weakening parental rights in working life an
Effects of Ice Nucleation Protein Repeat Number and Oligomerization Level on Ice Nucleation Activity
Ice nucleation active bacteria have attracted particular attention due to their unique ability to produce specific ice nucleation proteins (INpros), which are the most efficient ice nuclei known as they induce nucleation at temperatures close to 0°C. Our model bacterium Pseudomonas syringae strain R10.79 produced INpros containing 67 tandem repeats, forming the proposed ice-binding surface. To und
Effect of Human Myotubes-Derived Media on Glucose-Stimulated Insulin Secretion
Fasting to postprandial transition requires a tight adjustment of insulin secretion to its demand, so tissue (e.g., skeletal muscle) glucose supply is assured while hypo-/hyperglycemia are prevented. High muscle glucose disposal after meals is pivotal for adapting to increased glycemia and might drive insulin secretion through muscle-released factors (e.g., myokines). We hypothesized that insulin
Non-convex Rank/Sparsity Regularization and Local Minima
This paper considers the problem of recovering either a low rank matrix or a sparse vector from observations of linear combinations of the vector or matrix elements. Recent methods replace the non-convex regularization with ℓ1 or nuclear norm relaxations. It is well known that this approach recovers near optimal solutions if a so called restricted isometry property (RIP) holds. On the other hand i