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Optimizing flow cytometric DNA ploidy and S-phase fraction as independent prognostic markers for node-negative breast cancer specimens

Developing a reliable and quantitative assessment of the potential virulence of a malignancy has been a long-standing goal in clinical cytometry. DNA histogram analysis provides valuable information on the cycling activity of a tumor population through S-phase estimates; it also identifies nondiploid populations, a possible indicator of genetic instability and subsequent predisposition to metastas

Alternative NAD(P)H dehydrogenases of plant mitochondria

Plant mitochondria have a highly branched electron transport chain that provides great flexibility for oxidation of cytosolic and matrix NAD(P)H. In addition to the universal electron transport chain found in many organisms, plants have alternative NAD(P)H dehydrogenases in the first part of the chain and a second oxidase, the alternative oxidase, in the latter part. The alternative activities are

Skapande av femininitet : Om kvinnor i missbrukarbehandling

Popular Abstract in SwedishDenna avhandling handlar om kvinnor i missbrukarbehandling och deras beskrivningar av sig själva som kvinnor, den s.k. femininitetsprocessen. Syftet är att beskriva och försöka förstå behandlingens betydelse i kvinnornas femininitetsprocesser och vilken innebörd rusmedel, män, den egna kroppen, moderskap och sexualitet har och har haft däri. Avhandlingen har huvudsakligeThis thesis is about women in drug abuse treatment and their descriptions of themselves as women - their process of becoming feminine. The aim of the thesis is describing and trying to understand the meaning of the treatment in the women's femininity processes and what significance drugs, alcohol, men, the own body, motherhood, and sexuality have and have had in the process. The emphasis is on the

The influence of the number of thermal layers on the clothing insulation of a cold-protective ensemble

The required thermal insulation in cold conditions and time limits for cold exposure can be predicted by the thermal index IREQ/DLE (Insulation REQuired), described in ISO/TR-11079. The thermal insulation of a clothing ensemble can be measured with a thermal manikin or estimated according to ISO 9920. The basic thermal insulation of single garments (Iclu) can be summated to estimate the basic insu

Methotrexate ameliorates T cell dependent autoimmune arthritis and encephalomyelitis but not antibody induced or fibroblast induced arthritis

Objective: To investigate the mode of action of methotrexate (MTX) in different types of models for rheumatoid arthritis (RA) and multiple sclerosis (MS). Methods: Models for RA and MS were selected known to have different pathogenesis - that is, fibroblast induced arthritis in SCID mice, collagen induced arthritis (CIA), anticollagen II antibody induced arthritis (CAIA), and experimental autoimmu

Icodextrin improves the fluid status of peritoneal dialysis patients: Results of a double-blind randomized controlled trial

Worsening fluid balance results in reduced technique and patient survival in peritoneal dialysis. Under these conditions, the glucose polymer icodextrin is known to enhance ultrafiltration in the long dwell. A multicenter, randomized, double-blind, controlled trial was undertaken to compare icodextrin versus 2.27% glucose to establish whether icodextrin improves fluid status. Fifty patients with u

Case-based reasoning, a promising tool to face solids separation problems in the activated sludge process

Classical control has serious limitations when faced with solids separation problems in the activated sludge process. Lack of knowledge about the mechanisms involved in the imbalance within the different microbiological communities implies that a general solution to these undesirable situations has not yet been provided. However, operators have to make decisions based on their experience and intui

Combined oral and enema treatment with Pentasa (mesalazine) is superior to oral therapy alone in patients with extensive mild/moderate active ulcerative colitis: a randomised, double blind, placebo controlled study

Background and aims: Oral aminosalicylates are well established in the treatment of active mild/moderate ulcerative colitis (UC) when the disease is extensive (that is, beyond the splenic flexure). The majority of clinical symptoms relate to disease activity in the distal part of the colon and therefore this study was designed to investigate if adding a mesalazine enema to oral mesalazine has addi

Soft Security and the Presidency: Swedish Policy towards the Northern Dimension

The Council Presidency offered Sweden a possibility to contribute not only to a number of important issue areas but also to what we may call the ‘foreign policy’ side of the EU.A general question was, of course, what sort of impact Sweden could make in this field, given its background as a nonaligned and small state — a country generally regarded as hesitant in terms of supranational policy-making

Buda-Lund hydro model and the elliptic flow at RHIC

The ellipsoidally symmetric Buda-Lund hydrodynamic model describes naturally the transverse momentum and the pseudorapidity dependence of the elliptic flow in Au+Au collisions at roots(NN) = 130 and 200 GeV. The result confirms the indication of quark deconfinement in Au+Au collisions at RHIC, obtained from Buda-Lund hydro model fits to combined spectra and HBT radii of BRAHMS, PHOBOS, PHENIX and

Identification of the beta-dystroglycan binding epitope within the C-terminal region of alpha-dystroglycan

Dystroglycan is a receptor for extracellular matrix proteins that plays a crucial role during embryogenesis in addition to adult tissue stabilization. A precursor product of a single gene is post-translationally cleaved to form two different subunits, alpha and beta. The extracellular alpha-dystroglycan is a membrane-associated, highly glycosylated protein that binds to various extracellular matri

Reasoning with Limited Resources: Active Logics Expressed as Labeled Deductive Systems

Reasoning with limited computational resources (such as time or memory) is an important problem, in particular in knowledge-intensive embedded systems. Classical logic is usually considered inappropriate for this purpose as no guarantees regarding deadlines can be made. One of the moreinteresting approaches to address this problem is built around the concept of active logics. Although a step in th