In the past decades, transcriptomic studies have revolutionized cancer treatment and diagnosis. However, tumor sequencing strategies typically result in loss of spatial information, critical to understand cell interactions and their functional relevance. To address this, we investigate spatial gene expression in HER2-positive breast tumors using Spatial Transcriptomics technology. We show that exp

Studien syftade till att undersöka hur kvinnor från Irak och f.d. Jugoslavien, diagnostiserade med bröstcancer och boende i Sverige, upplever sin vardag under strålbehandling. En kvalitativ forskningsdesign användes som bestod av intervjuer med tio kvinnor, fem med ursprung i Irak och fem från f.d. Jugoslavien. Strävan för att överleva medförde att kvinnorna upplevde sin vardag under strålbehandliThis study aimed at exploring how women from Iraq and the former Yugoslavia, diagnosed with breast cancer and living in Sweden, experience their everyday life during radiation therapy. A qualitative research design was used comprising interviews with ten women, five originating from Iraq and five from the former Yugoslavia. Striving to survive, the women experienced their everyday life during radi

Bokkapitel i Handbook of Nuclear Medicine and Molecular Imaging for Physicistsutoradiography is defined as technologies and methods used to produce a two-dimensional image of the distribution of activity in, or on, a thin and solid sample that is in close proximity to the detector. The images are usually formed by charged particles (α or β±), and image characteristics are determined both by the detector and the properties of the particles detected. This method is not widely

The competition between a spherical macroion and a polyelectrolyte in complexation with an oppositely charged flexible polyelectrolyte has been studied by means of Monte Carlo simulations. A simple model system with focus on the electrostatic interactions has been used to investigate under what conditions the macroion in a polyelectrolyte-macroion complex (excess of polyelectrolyte charges) is exc

The structural properties of the salivary proteins, acidic proline rich PRP-1 and statherin, adsorbed onto negatively charged surfaces have been studied by Monte Carlo simulations and ellipsometry. It is shown that both proteins adsorb to negatively charged surfaces, although their net charges are negative. Experimentally, an initial fast mass-controlled film build-up was detected for both protein

The structural properties of the salivary protein statherin upon adsorption have been examined using a coarse-grained model and Monte Carlo simulation. A simple model system with focus on electrostatic interactions and short-ranged attractions among the uncharged amino acids has been used. To mimic hydrophobically modified surfaces, an extra short-ranged interaction was implemented between the ami

Historical data are valuable resources for providing insights into general patterns in the past. However, these data often inform us at the macro-level of analysis but not about the role of individuals’ behaviours in the emergence of long-term patterns. Therefore, it is difficult to infer ‘how’ and ‘why’ certain patterns emerged in the past. Historians use various methods to draw hypotheses about

Fire regimes across the world are expected to be altered by continuing variations in socio-economic conditions and climate. Current global fire-vegetation models are able to represent the present-day fire activity, but it is unclear how well they can simulate past or future scenarios. Here we use sedimentary charcoal-based biomass burning reconstructions to evaluate fire probability and total carb

BackgroundA concussion is a common injury in many sports, including para sport. Aside from a more comprehensive need for concussion education, clinicians face difficulties applying concussion assessment and management guidelines to para athletes.1 At present, there is a lack of para-sport concussion research, and prior International Concussion in Sport (CIS) consensus papers have not addressed thi

We review recent developments in PYTHIA8, focused on heavy ion collisions. The ANGANTYR framework for heavy ion collisions is presented, as well as recent developments of the string shoving model for flow. It is further shown how string shoving can affect jet fragmentation in pp collisions. The effect of adding hadronic rescattering is reviewed, with focus on the nuclear modification factor, and f

Di-jet observables are excellent probes to study the effect of jets in dense systems. Interacting Lund strings will affect jet observables and suggests a new common mechanism responsible for jet modification in p-A and A-A. In this proceeding, we present our new implementation of the string shoving mechanism in PYTHIA8 which lets us study the effects on jet observables in p-p and nuclear collision

Rättsfallspodd från Juridiska fakulteten

Rättsfallspodd från Juridiska fakulteten

Nonlinear responses to externally forced climate change are known to dampen or amplify the local climate impact due to complex cross-compartmental feedback loops in the Earth system. These feedbacks are less well represented in the traditional stand-alone atmosphere and ocean models on which many of today's regional climate assessments rely (e.g., EURO-CORDEX, NOSCCA and BACC II). This has promote