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This paper presents a methodology for cost estimation in developing decision support for production location issues.The purpose is to provide a structured work procedure to be used by practitioners to derive the knowledge needed to makeinformed decisions on where to locate production. This paper present a special focus on how to integrate cost effects duringthe decision process. The result is a st

Objective: To investigate whether women raised in a family with substance abuse constitute a particularly vulnerable group of patients in an infant psychiatry setting and to identify the risk factors of suspected parental malfunctioningin women referred to treatment in an infant and toddler intervention program.Background: A history of family substance abuse can severely disrupt the caretaking abi

OBJECTIVES: Quantitative monitoring of human cytomegalovirus infections is helpful in determining appropriate antiviral management in patients who receive bone marrow transplants. We sought to design and evaluate a new cytomegalovirus capture hybrid polymerase chain reaction enzyme-linked immunosorbent assay (PCR-ELISA) in plasma and peripheral blood mononuclear cells to monitor cytomegalovirus in

Early psychosocial adversities and maladjustment, such as childhood maltreatment and school adjustment problems, have been linked to an increased risk of aggressive antisocial behaviors. Yet, clinical studies of subjects at the highest risk of persistence in such behaviors are rare, especially during the life-changing transition years of emerging adulthood. This study describes early predictors of

One of the well-recognized problems of long-term L-3,4-dihydroxyphenylalanine (L-DOPA) therapy in the treatment of Parkinson's disease is the development of L-DOPA induced dyskinesia. These abnormal movements cause significant disability and narrow the therapeutic window of L-DOPA. Cell transplantation is one of the most promising upcoming therapies for the treatment of Parkinson's disease, and ma

Preclinical and clinical data stress the importance of pharmacologically-controlling glial cell line-derived neurotrophic factor (GDNF) intracerebral administration to treat PD. The main challenge is finding a combination of a genetic switch and a drug which, when administered at a clinically-approved dose, reaches the brain in sufficient amounts to induce a therapeutic effect. We describe a highl

Abnormal involuntary movement (AIM) rating scales are frequently used to study the mechanisms underlying L-DOPA-induced dyskinesia (LID) in 6-OHDA lesioned rodents and the propensity of novel treatments for Parkinson's disease to induce or alleviate similar abnormal behaviours. Despite the existence of at least one well validated method, other AIM scales are also in use. Moreover, there have been

Foetal cell transplantation in patients with Parkinson's disease can induce motor complications independent of L-DOPA administration, known as graft-induced dyskinesia. In the 6-OHDA lesioned rat model of Parkinson's disease, post-transplantation abnormal movements can develop in response to an amphetamine challenge, a behaviour which is used to model graft-induced dyskinesia. Although L-DOPA-indu

Causative meaning including, but not limited to, causation, prevention, and enabling is realized in language use through force construal. Force is explored in this article through consideration of narratives on Tourette Syndrome, a disorder that is largely characterized by its constitutive actions (i.e. vocal and motor tics). To account for force construal, the article proposes a merger of a vecto

LFNMR relaxometry was applied to determine the spin-spin relaxation time (T2) of water saturated Norway spruce samples cut from mature sapwood and mature and juvenile heartwood where earlywood and latewood were separated. In combination with quantitative wood anatomy data focusing on the void volumes in various morphological regions, the NMR data served for a more reliable assignment of free waterLow-field nuclear magnetic resonance (LFNMR) relaxometry was applied to determine the spin-spin relaxation time (T2) of water-saturated Norway spruce (Picea abies (L.) Karst.) specimens cut from mature sapwood (sW) and mature and juvenile heartwood (hW), where earlywood (EW) and latewood (LW) were separated. In combination with quantitative wood anatomy data focusing on the void volumes in various

The use of this material under current use conditions is supported by the existing information.This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog, benzyl acetate (CAS # 140-11-4), show that this m

Summary Ribonucleotide reductases (RNRs) reduce ribonucleotides to deoxyribonucleotides. Their overall activity is stimulated by ATP and downregulated by dATP via a genetically mobile ATP cone domain mediating the formation of oligomeric complexes with varying quaternary structures. The crystal structure and solution X-ray scattering data of a novel dATP-induced homotetramer of the Pseudomonas aer