Hippo signaling is a key regulator of organ size, tissue hemostasis and regeneration. Dysregulation of the Hippo pathway has been recognized in a variety of human cancers, including pancreatic cancer. YES-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are the two major downstream effectors of the Hippo pathway. YAP and TAZ have been found to promote pancreati

While scholars commonly assume that Global Governance Institutions (GGIs) need legitimacy to perform effectively, there are few systematic empirical studies assessing the consequences of legitimacy (or the lack thereof) for the functioning of GGIs. Inspired by the new institutionalism in organization theory, which predicts that more legitimate organizations will get more resources than illegitimat

The existing information supports the use of this material as described in this safety assessment. Methyl 2-nonenoate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog ethyl trans-2,cis-4-decadienoate (CAS # 3025-30-7) show that methy

Phenomenology strives for the actualization of contact. As a way of study it seeks to meet the things of the world as those things are in themselves and so describe them. Geography studies the earth as the dwelling place of man. As one of its tasks, it seeks to understand how people live in relation to everyday places, spaces, and environments. A phenomenological geography borrows from both fields

Aim: The mechanisms of plant trait adaptation and acclimation are still poorly understood and, consequently, lack a consistent representation in terrestrial biosphere models (TBMs). Despite the increasing availability of geo-referenced trait observations, current databases are still insufficient to cover all vegetation types and environmental conditions. In parallel, the growing number of continuo

Atopic dermatitis (AD) is a common inflammatory skin disease that affects both children and adults, including a large number of adults of reproductive age. Several guidelines for the treatment of AD exist, yet specific recommendations for the treatment of pregnant or lactating women and for adults planning to have a child are often lacking. This position paper from the European Task force on Atopi

Scania in southern Sweden is an important staging and wintering province for the Bean Goose Anser fabalis, especially for the Taiga form A. f. fabalis. Based on counts in October, November and January 1977/1978– 2016/2017, and observations of neck-banded individuals, the changes in local distribution are described. When the counts started, large numbers were counted already in October, but autumn

Technological developments of the last decades allow the production and the dispersion of particles of sizes ranging between 10 and 100 nm in liquids. In a large number of recent studies the resulting nanofluids have been reported to display anomalously high increase in convective heat transfer. The present study compiles experiments from five independent research teams investigating convective he

Genetic studies promise to provide insight into the molecular mechanisms underlying type 2 diabetes (T2D). Variants associated with T2D are often located in tissue-specific enhancer clusters or super-enhancers. So far, such domains have been defined through clustering of enhancers in linear genome maps rather than in three-dimensional (3D) space. Furthermore, their target genes are often unknown.

Background: The underlying physiology of the intracranial pressure (ICP) curve morphology is still poorly understood. If this physiology is explained it could be possible to extract clinically relevant information from the ICP curve. The venous outflow from the cranial cavity is pulsatile, and in theory the pulsatile component of venous outflow from the cranial cavity should be attenuated with inc

Police work may include performing repeated tasks under the influence of psychological stress, which can affect perceptual, cognitive and motor performance. However, it is largely unknown how repeatedly performing stressful tasks physically affect police officers in terms of heart rate and pupil diameter properties. Psychological stress is commonly assessed by monitoring the changes in these bioma

Cancer-associated gene fusions resulting in chimeric proteins or aberrant expression of one or both partner genes are pathogenetically and clinically important in several hematologic malignancies and solid tumors. Since the advent of different types of massively parallel sequencing (MPS), the number of identified gene fusions has increased dramatically, prompting the question whether they all have

The aim of this study was to find a solvent to replace N-methyl-2-pyrrolidone (NMP) in CO2 absorption systems containing the amine 2-amino-2-methyl-1-propanol (AMP), in order to reduce the health risks associated with handling, as NMP is reproductively toxic. Seven organic solvents were investigated: dimethyl sulfoxide (DMSO), 3-(dimethylamino)propionitrile (3DMAPN), 1-pentanol (1 P), propylene ca

As a result of increasing bacterial resistance against antibiotics, we are facing an emerging health crisis, in which ‘simple’ infections may no longer be treatable. One class of molecules attracting interest in this context is antimicrobial peptides (AMPs), and considerable research efforts have been directed to identifying selective and potent AMPs. In addition, since in vivo delivery of AMPs is