CDK4/6 inhibitors (CDK4/6i) combined with endocrine therapy have shown impressive efficacy in estrogen receptor-positive advanced breast cancer. However, most patients will eventually experience disease progression on this combination, underscoring the need for effective subsequent treatments or better initial therapies. Here, we show that triple inhibition with fulvestrant, CDK4/6i and AKT inhibi

OBJECTIVE: The aim of the present study was to examine the effects of incomplete surgery and adjuvant chemotherapy on the prognosis of patients with intraoperative rupture of capsulated stage I epithelial ovarian cancer (OvCa). METHODS: A regional retrospective study was conducted between 1986 and 2019. Among 4,730 patients with malignant ovarian tumors, 534 women with International Federation of

We describe an analysis comparing the p¯p elastic cross section as measured by the D0 Collaboration at a center-of-mass energy of 1.96 TeV to that in pp collisions as measured by the TOTEM Collaboration at 2.76, 7, 8, and 13 TeV using a model-independent approach. The TOTEM cross sections, extrapolated to a center-of-mass energy of √s=1.96 TeV, are compared with the D0 measurement in the region of

The research presented in this thesis is primarily focused on experimental investigations of laser-driven ion acceleration from solid targets via the target normal sheath acceleration mechanism. In particular, ways of optimizing the absorption of the laser pulse energy by free plasma electrons in the target, or modifying the shape of the accelerating electron sheath were addressed. The aim of this

Objective: To investigate if the extent of absent end-diastolic flow (AEDF) on umbilical artery (UA) Doppler velocimetry predicts pregnancy outcome. Methods: This was a retrospective observational study based on data from 25 000 Doppler examinations of UA flow performed between 1998 and 2017 at the Blood Flow Laboratory, Level III Perinatal Center, Lund, Sweden. All pregnancies with AEDF in the UA

In this Medium contribution, we take a closer look at the potential of exploiting the ordinary user’s digital (il)literacy in their search practices. We explore how the logic of search engines, and missing or low-quality data are vulnerable to extreme-right manipulations.

The notion of Cloud RAN is taking a prominent role in narrative for the next generation wireless infrastructure. It is also seen as a mean to industrial communication systems. In order to provide reliable wireless connectivity for industrial deployments, by conventional means, the cloud infrastructure needs to be reliable and incur little latency, which however, is contradictory to the stochastic

Background: The classic Bernard-Soulier syndrome (BSS) is a rare inherited thrombocytopenia (IT) associated with severe thrombocytopenia, giant platelets, and bleeding tendency caused by homozygous or compound heterozygous variants in GP1BA, GP1BB, or GP9. Monoallelic BSS (mBSS) associated with mild asymptomatic macrothrombocytopenia caused by heterozygous variants in GP1BA or GP1BB may be a frequ

When in use, a mobile terminal is often held in the hand by the user. However, conventionally terminal antennas are only evaluated in free space, disregarding the effects of user interaction. In this paper, the performance of a low-profile twoport multiple-input multiple-output (MIMO) antenna that offers wide symmetrical bandwidth and low correlation in free space is investigated in presence of a

Ferroelectric and ferroelastic domains have been predicted to enhance metal halide perovskite (MHP) solar cell performance. While the formation of such domains can be modified by temperature, pressure, or strain, established methods lack spatial control at the level of single domains. Here, we induce the formation of ferroelastic domains in CsPbBr3 nanowires at room temperature using an atomic for

Background: The risk to develop memory impairment in has been widely investigated in type 2 diabetes (T2D). There are several mechanisms proposed for T2D-associated cognitive impairment, such as brain insulin resistance, synaptic dysfunction, inflammation, gliosis, or disruption of neuron-astrocyte interactions (Garcia-Serrano & Duarte, 2020). On the other hand, supplementation with the antiox