Mature aggrecan is generally C-terminally truncated at several sites in the CS (chondroitin sulfate) region. Aggrecanases and MMPs (matrix metalloproteinases) have been suggested to be responsible for this digestion. To identify whether calpain, a common intracellular protease, has a specific role in the proteolysis of aggrecan we developed neoepitope antibodies (anti-PGVA, anti-GDLS and anti-EDLS

The lectin, phytohaemagglutinin (PHA), from red kidney beans has been shown as an inducer of growth and precocious gastrointestinal (Cl) maturation in suckling animals, thus better preparing piglets for the weaning procedure. PHA exposure results in the release of gut peptide hormones and/or activation of the Cl immune system. The aim of this study was to elucidate the mechanisms of PHA provocatio

Popular Abstract in Swedish Skador i knäleden är vanligt förekommande och främre korsbandsskada drabbar i Sverige årligen mer än 8 per 10 000 personer i åldern 10-64 år. Följderna av skadan kan bli bestående funktionsnedsättning med bl.a. instabilitet, plötsliga och smärtsamma knäledsvikningar och ökad risk för nya skador. Cirka hälften av patienterna utvecklar ledsvikt (artros) 10-15 år efter denThe purpose of this thesis was to increase the understanding of altered movement patterns in individuals with anterior cruciate ligament (ACL) injury in order to improve ACL rehabilitation, and to develop an observational instrument termed Test for Substitution Patterns (TSP) for standardized, quantifiable scoring of altered movement patterns in legs and trunk. In all, 142 participants, 93 with A

A search for long-lived particles is performed using a data sample of 4.7 fb(-1) from proton-proton collisions at a centre-of-mass energy. root s = 7 TeV collected by the ATLAS detector at the LHC. No excess is observed above the estimated background and lower limits, at 95% confidence level, are set on the mass of the long-lived particles in different scenarios, based on their possible interactio

This study compares the children and adult response to a novel postural challenge. One group of children (n = 13, age 7-9) and one adult reference group (n = 12 age 15-32) were subjected to vibration induced body sway and posturography with both open and closed eyes for 5 consecutive days. There was a gradual decrease of induced body sway over time in both groups (p < 0.001) between the subsequent

Review of Andrej Nekrasov, Disbelief

Stable carbon isotopes play an important role in the interpretation of biological activity, particularly when the fossil record is studied. In combination with morphological and chemical data, isotopic information can be useful in paleontology and astrobiology. In this paper the development of a microanalytical ion beam system for the measurement of the carbon isotope ratio with high spatial resol

Iii analysis-by-synthesis linear predictive coding (AbS-LPC) an LPC synthesis filter is combined with an analysis-by-synthesis search of the excitation signal. The synthesis filter is an estimator for the speech signal given the excitation. However in most AbS-LPC algorithms this estimator has no explicit model of the quantization noise, which is present in the excitation signal. This paper descri

A set of rectangles S is said to be gridpacked if there exists a rectangular grid (not necessarily regular) such that every rectangle lies in the grid and there is at most one rectangle of S in each cell. The area of a grid packing is the area of a minimal bounding box that contains all the rectangles in the grid packing. We present an approximation algorithm that given a set S of rectangles and a

We have investigated the binary system of a triblock copolymer of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), EO5PO68EO5, in water. The ternary system with the same polymer, water and soybean phosphatidylcholine (lecithin) has also been studied. Small-angle X-ray scattering (SAXS), 2H NMR and differential scanning calorimetry (DSC) were used to characterize these systems. The phase

Popular Abstract in Swedish Kroppens immunförsvar, vars uppgift är att skydda oss mot infektioner, består av ett antal olika celltyper som till stor del finns i blodet. Immunförsvaret kan indelas i två delar; ett medfött försvar som är likadant hos alla individer och ett försvar som byggs upp under individens livstid. Det senare utformas olika beroende på vilka bakterier och virus som individen utThe cells of the innate immune system are essential for the host's first line defence against infection. Among these cells the neutrophil granulocyte has a central role by the production of antibiotic proteins and peptides. These are targeted for storage in secretory lysosomes and other neutrophil granules for subsequent release by regulated secretion in an inflammatory process. However, the granu

Background & objectives: We have earlier proposed that group A streptococcal (GAS) immunoglobulin binding surface proteins (IgGBPs) might trigger anti-IgG production and immune complex formation leading to glomerulonephritis. In the present study, cardiac tissue material from rabbits injected with heat-killed GAS was investigated. Methods: Rabbits were injected intravenously with 10(9) colony

We investigated the effects of an exotic snail, the golden apple snail (Pomacea canaliculata) on biodiversity and ecosystem functioning in tropical wetland ecosystems. This large snail (up to 80-mm shell height) has invaded large parts of Southeast Asia during recent decades. A survey of natural wetlands in Thailand showed that high densities of the snail were associated with almost complete absen

We develop a uniform semiclassical trace formula for the density of states of a three-dimensional isotropic harmonic oscillator (HO), perturbed by a term 1/4 epsilon r(4). This term breaks the U(3) symmetry of the HO, resulting in a spherical system with SO(3) symmetry. We first treat the anharmonic term for small e in semiclassical perturbation theory by integration of the action of the perturbed