Human leukocyte antigen class I (HLA-I) molecules are present on the cell surface of all nucleated cells. They bind intracellular peptides and present them to the immune system thus providing a readout to cytotoxic T-cells about the status of a cell. Maturation of the HLA-I molecule includes peptide binding in the endoplasmic reticulum with the assistance of several other proteins collectively cal

Background: Based on a large, representative unscreened cohort from Malmo, Sweden, we have recently reported that a single prostate-specific antigen (PSA) measurement at or before age 50 is a strong predictor of prostate cancer occurring up to 25 years subsequently. We aimed to determine whether this association holds for advanced cancers, defined as clinical stage T3 or higher, or skeletal metast

Combining state-of-the-art density functional theory (DFT) calculations with high resolution core level shift spectroscopy experiments we explored the reaction mechanism of the ammonia oxidation reaction over RuO2(1 1 0). The high catalytic activity of RuO2(1 1 0) is traced to the low activation energies for the successive hydrogen abstractions of ammonia by on-top O (less than 73 kJ/mol) and the

Background: The proven benefit of integrating cervical cancer screening programme into HIV care has led to its adoption as a standard of care. However this is not operational in most HIV clinics in Nigeria. Of the various reasons given for non-implementation, none is backed by scientific evidence. This study was conducted to assess the willingness and acceptability of cervical cancer screening amo

Sarcomas are relatively rare malignancies and include a large number of histological subgroups. Based on morphology alone, the differential diagnoses of sarcoma subtypes can be challenging, but the identification of specific fusion genes aids correct diagnostication. The presence of individual fusion products are routinely investigated in Pathology labs. However, the methods used are time-consumin

This review outlines the pearls and pitfalls of calcitonin-gene related protein (CGRP) immunohistochemistry of the brain. Pearls: In 1985, CGRP was first described in cerebral arteries using immunohistochemistry. Since then, cerebral CGRP (and, using novel antibodies, its receptor components) has been widely scrutinized. Here, we describe the distribution of cerebral CGRP and pay special attention

The excited-state structure of a dinuclear platinum(II) complex with tert-butyl substituted pyrazolate bridging units, [Pt(ppy)(μ-(t)Bu(2)pz)](2) (ppy = 2-phenylpyridine; (t)Bu(2)pz = 3,5-di-tert-butylpyrazolate) is studied by X-ray transient absorption (XTA) spectroscopy to reveal the transient electronic and nuclear geometry. DFT calculations predict that the lowest energy triplet excited state,

Popular Abstract in Swedish Vid vår vanligaste ledsjukdom, artros, sker en progressiv förstöring av ledbrosk beroende på en störd balans mellan nedbrytning och nybildning av broskets extracellulära matrix. Ledbrosket utsätts för stort slitage och broskceller – kondrocyter – glest positionerade i vävnaden står för både nysyntes av broskmolekyler och för huvuddelen av nedbrytandet av slitna molekyleBackground: In osteoarthritis (OA) the balance of cartilage matrix synthesis and degradation is disturbed, resulting in a gradual destruction of the articular cartilage. Matrix components released into body fluids by proteolytic cleavage can be used as biomarkers of ongoing processes. This thesis focuses on proteolytic degradation of the proteoglycan aggrecan with the overall aim to study the pote

The paper is concerned with estimation of heat and power consumption in a conceptual plant to produce hydrogen from sucrose-containing or starchy biomass by fermentation. A hydrogen plant connected with a sugar factory is regarded as the basic option; the sugar factory serves as a source of sucrose-containing thick juice for the hydrogen plant, where this feedstock is processed to hydrogen. As ano

A measurement of event-plane correlations involving two or three event planes of different order is presented as a function of centrality for 7 mu b(-1) Pb + Pb collision data at v root s(NN) = 2.76 TeV, recorded by the ATLAS experiment at the Large Hadron Collider. Fourteen correlators are measured using a standard event-plane method and a scalar-product method, and the latter method is found to

This article deals with the scientific factors that have contributed to the dominance of motorised transport and the development of theoretical approaches in transport planning. Connections are made to modernism and to the theories within the field of transport planning that have created today’s transport systems. Connections are then made to the field of bicycle planning. It is argued that there

Biographic sketches are provided for 19 of Austrian botanists who contributed in different ways to the knowledge on lichens of the European Alps: Othmar Breuss, Carl Wilhelm von Dalla Torre, Helmut Gams, Georg Gärtner, Martin Grube, Josef Hafellner, Karl von Keissler, Ernst Kernstock, Helmut Mayrhofer, Walter Obermayer, Josef Poelt, Karl Redinger, Julius Steiner, Elfriede Stocker-Wörgötter, Elisab

Abstract in UndeterminedGaps in measured discharge series are common in Iceland, especially during winter, but reconstructed series are needed for a number of applications. Modeled series are therefore sometimes used to fill the gaps to create a continuous series, but the modeled inserts may have different statistical characteristics from the observed series, whilst their initial and final values

Popular Abstract in Swedish Personlighetspsykologer har i mer än ett århundrade försökt att identifiera och beskriva observerbara skillnader mellan individer. Bland dessa indiduella skillnader har intelligens och personlighet fått stor uppmärksamhet inom skolvärlden, liksom elevers förhållningssätt till sitt lärande. Kunskapen om vilka faktorer som påverkar studieresultat har viktiga praktiska konThe aim of the present doctoral thesis was to examine to what extent personality traits and approaches to learning contribute to academic performance in upper secondary school (high school), after controlling for the well-known fact that general intelligence accounts for a large part of the variance. The general proposition of the thesis is that personality traits are stable dispositons and theref

We have compared the predictions of ligand-binding affinities from several methods based on end-point molecular dynamics simulations and continuum solvation, i.e. methods related to MM/PBSA (molecular mechanics combined with Poisson-Boltzmann and surface area solvation). Two continuum-solvation models were considered, viz. the Poisson-Boltzmann (PB) and generalised Born (GB) approaches. The non-el

This paper presents a novel observation on Swedish subordinate clause structure. I show that in embedded V2 clauses, negation may only precede quantified subjects in the position following the complementizer; this is the very same limitation as found in the first position of main clauses. This correlation I take to provide a strong argument for assuming V-to-C movement in embedded V2 clauses. This