We used in situ hybridization histochemistry to study the expression of the mRNA of the two vesicular monoamine transporters (VMAT1 and VMAT2) during embryonic and postnatal development of the central nervous system (CNS) int he rat. In the adult rat, VMAT2 mRNA is present exclusively in monoaminergic cell groups of the CNS and VMAT1 mRNA was reported to be present in the adrenal medulla and certa

Aims: Clinical trials have demonstrated that a reduction in low-density lipoprotein cholesterol (LDL-C) reduces cardiovascular (CV) events. This has, however, not yet been shown in a real-world setting. We aimed to investigate the association between LDL-C changes and statin intensity with prognosis after a myocardial infarction (MI). Methods and results: Patients admitted with MI were followed fo

The aim of this study was to examine and construct a theoretical model of key elements that care workers perceive to have an impact on their autonomy, cohesion, and work motivation. Grounded theory was used for data collection and analysis. There were 20 participants from social welfare service, geriatric care, and women’s aid settings (women = 18, men = 2, mean age = 37.6). The analysis resulted

The existing information supports the use of this material as described in this safety assessment. 3,7-Dimethyl-1,3,6-octatriene was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from 3,7-dimethyl-1,3,6-octatriene and read-across analog myr

This article takes as its starting point the similar, yet differing, experiences of hearing voices among prisoners in Myanmar. It discusses why the experience of hearing voices described by prisoners is regarded as an occasion to share compassion when it occurs during meditation retreats and as torture when it occurs in solitary confinement. The article uses the concept of liminality to make sense

Curvature in lipid-based biomembranes provides compartmentalization in cells and can act as regulator of biological activity in living systems. The study of these biomembranes require novel model systems and new methods. In this work I have used a supported phospholipid bilayer on a hexagonal array of silicon nanowires. The nanowires impose curvature on the supported lipid bilayer and the resultin

The pinch-off dynamics during hydrogen bubble formation was experimentally investigated in a cross-junction microchannel. A binarization interface recognizing and key frame tracking method was established. By analyzing the breakup dynamics through spatial and time domains, the effects of interfacial tension and viscosity on hydrogen bubble pinch-off were revealed. A transitional stage between a li

Activated normal density granulocytes (NDGs) can suppress T-cell responses in a similar way as myeloid-derived suppressor cells (MDSCs). In this study, we tested the hypothesis that NDGs from blood and bone marrow of multiple myeloma (MM) patients have the ability to suppress T-cells, as MDSC. MM is an incurable plasma cell malignancy of the bone marrow. Like most malignancies, myeloma cells alter

In this study, multilayered Cu mesh/AZ31 Mg foil composites were designed and fabricated by diffusion bonding in a closed graphite mold at 400–445 °C. The effects of temperature on the microstructure of the joints formed and the thermal conductivity of the composite was evaluated. The mechanism responsible for the observed improvement in thermal conductivity was analyzed. After diffusion bonding,

PURPOSE OF REVIEW: Malnutrition is frequent in patients with acute kidney injury. Nutrient clearance during renal replacement therapy (RRT) potentially contributes to this complication. Although losses of amino acid, trace elements and vitamins have been described, there is no clear guidance regarding the role of micronutrient supplementation. RECENT FINDINGS: A scoping review was conducted with t

Abstract: Males and females often have divergent evolutionary interests, generating sexual conflicts. This is particularly true in organisms that exhibit facultative sexuality, whereby females are capable of reproducing without fitness costs of mating. Here, we provide the first documented evidence with quantitative tracking showing that sex interacts with social context to determine space-use of

Since the beginning of African decolonisation in the mid-twentieth century, many newly independent countries struggled to embark upon a path of sustained economic growth to raise their populations out of poverty. One of these countries is Tanzania. Surrounded by the Great Lakes on the west and bordering the Indian Ocean to the east, Tanzania is the fifth-most populous country in Africa. It is also

We suggest that a renewed focus on integration (broadly conceived) would enablethe field to contemplate the ways in which crisis dynamics interconnect with and amplify three founding and (and unresolved) dilemmas of the European project. These can be summarized as (a) the constant tension between the goal of delivering an EU-wide market order versus the desire to ensure social solidarity, (b) the

This paper applies an analytical method for developing policy strategies to optimize municipal waste management systems (MWMSs) to the case of the Land of Fires (LoF). The LoF is an area of Italy’s Campania region that is characterized by a legacy of authoritarian environmental governance and the improper dumping and burning of waste. In this paper, we employ the fuzzy cognitive maps (FCM) method,

Anorectal malformations (ARM) are a spectrum of congenital malformations, specifically defined by the absence of a normal anal opening. These conditions are treated surgically by posterior sagittal anorectoplasty and, in cases with perineal fistulas, perineal skin advancement is required to cover the tissue defect. Complications involving wound dehiscence are frequent, and may be due to stretchingAnorectal malformations (ARM) are a spectrum of congenital malformations, specifically defined by the absence of a normal anal opening. These conditions are treated surgically by posterior sagittal anorectoplasty and, in cases with perineal fistulas, perineal skin advancement is required to cover the tissue defect. Complications involving wound dehiscence are frequent, and may be due to stretching

Introduction: This article explores explanations for attitudes towards the acceptability of transactional sex. The sparse research investigating attitudes towards transactional sex uncovers a link between gender equality, or feminism, and a lack of support for the trade in sex. However, there are no research agendas that attempt to explain variance in attitudes towards transactional sex where supp