Sökresultat

Filtyp

Din sökning på "*" gav 531497 sökträffar

Self-assembly of Fe nanocluster arrays on templated surfaces

The growth of Fe nanoclusters on the Ge(001) and MoO2/Mo(110) surfaces has been studied using low-temperature scanning tunneling microscopy (STM) and X-ray magnetic circular dichroism (XMCD). STM results indicate that at low coverage Fe atoms self-assemble on both surfaces into well-separated nanoclusters, which nucleate at equivalent surface sites. Their size, shape, and the observed spatial sepa

Infliximab or cyclosporine as rescue therapy in hospitalized patients with steroid-refractory ulcerative colitis: A retrospective observational study

Background: Cyclosporine (CsA) or infliximab (IFX) are used as rescue therapies in steroid-refractory, severe attacks of ulcerative colitis (UC). There are no data comparing the efficacy of these two alternatives. Methods: Outcome of rescue therapy was retrospectively studied in two cohorts of patients hospitalized due to steroid-refractory moderate to severe UC: 1) a Swedish-Danish cohort (n 49)

How the care managers handle the situation when older people consider relocation to a residential home

The aim of this article is to reveal how care managers handle the process when older people consider relocation to a residential home in a Swedish context. The article is based on vignette-based interviews with seven care managers. The main findings in the article are that the care managers assist older people in their decisions by turning ageing in place and relocation respectively into seemingly

Protein tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling

Fms-like tyrosine kinase 3 (FLT3) plays an important role in hematopoietic differentiation and constitutively active FLT3 mutant proteins contribute to the development of acute myeloid leukemia (AML). Little is known about the protein tyrosine phosphatases (PTP) affecting the signaling activity of FLT3. To identify such PTP, myeloid cells expressing wild type FLT3 were infected with a panel of len

Size-Dependent Effects of Nanoparticles on Enzymes in the Blood Coagulation Cascade.

Nanoparticles (NPs) are increasingly used in diagnostic and drug delivery. After entering the bloodstream, a protein corona will form around NPs. The size and curvature of NPs is one of the major characteristics affecting the composition of bound protein in the corona. Key initiators of the intrinsic pathway of blood coagulation, the contact activation complex, (Kallikrein, Factor XII, and high mo

Students' reflections in a portfolio pilot: Highlighting professional issues.

Background: Portfolios are highlighted as potential assessment tools for professional competence. Although students' self-reflections are considered to be central in the portfolio, the content of reflections in practice-based portfolios is seldom analysed. Aim: To investigate whether students' reflections include sufficient dimensions of professional competence, notwithstanding a standardized port

Calcium Regulates the Activity and Structural Stability of Tpr, a Bacterial Calpain-like Peptidase.

Porphyromonas gingivalis is a peptide-fermenting asaccharolytic periodontal pathogen. Its genome contains several genes encoding cysteine peptidases other than gingipains. One of these genes (PG1055) encodes a protein called Tpr (thiol protease), which has sequence similarity to cysteine peptidases of the papain and calpain families. In this study, we biochemically characterize Tpr. We found that

Search for neutral Higgs bosons of the minimal supersymmetric standard model in pp collisions at root s=8 TeV with the ATLAS detector

A search for the neutral Higgs bosons predicted by the Minimal Supersymmetric Standard Model (MSSM) is reported. The analysis is performed on data from proton-proton collisions at a centre-of-mass energy of 8 TeV collected with the ATLAS detector at the Large Hadron Collider. The samples used for this search were collected in 2012 and correspond to integrated luminosities in the range 19.5-20.3 fb

Optimizing nanovial outlet designs for improved solid-phase extraction in the integrated selective enrichment target-ISET.

The integrated selective enrichment target is a microfluidic platform for SPE sample preparation with integrated nanocolumns, which simultaneously offers direct MALDI MS read-out. Here, we present a study on the importance of different nanocolumn outlet hole geometries and hole areas in relation to MS signal intensity and reproducibility. A design solution that provides the flow characteristics re

Enzymatic monitoring of lignin and lignin derivatives biooxidation.

Lignin oxidation was enzymatically monitored by measuring methanol released during the reaction. The methanol was oxidized to formaldehyde and hydrogen peroxide, and the latter used to oxidize ABTS to a product measured spectrophotometrically. The efficiency was comparable to the commonly used gas chromatography method. The assay was fast and inexpensive.

Value assessment and pricing capabilities—how to profit from value

Value is a key concept for researchers and practitioners in the fields of strategy, marketing, and pricing. In the strategy literature, value is closely related to competitive advantage and profit, in the marketing literature value is the cornerstone of the marketing management process, in the pricing literature value represents the customer’s willingness to pay. The aim of this article is to brid

An hybrid evolutionary multiobjective algorithm for multiuser margin maximization in DSL

This work describes and proposes the application of evolutionary algorithms on the multiuser spectrum and SNR margin optimization problem for multicarrier systems, such as digital subscriber line. The proposed method is designed such that it takes advantage of special characteristics of the well-known power adaptation techniques and uses them to solve the broader and more challenging problem of mu

Search for pair production of first or second generation leptoquarks in proton-proton collisions at root s=7 TeV using the ATLAS detector at the LHC

This paper describes searches for the pair production of first or second generation scalar leptoquarks using 35 pb(-1) of proton-proton collision data recorded by the ATLAS detector at root s = 7 TeV. Leptoquarks are searched in events with two oppositely-charged muons or electrons and at least two jets, and in events with one muon or electron, missing transverse momentum and at least two jets. Af

Networks for the e-society

The 14th edition of International Telecommunications Network Strategy and Planning Symposium (shortly: Networks 2010) held in Warsaw, Poland. Networks 2010 was a four-day professional and scientific event organized by Warsaw University of Technology in co-operation with Polish Association of Telecommunication Engineers (SIT). The conference was focused on network design and planning methods includ

The Stroke Riskometer (TM) App: Validation of a data collection tool and stroke risk predictor

BackgroundThe greatest potential to reduce the burden of stroke is by primary prevention of first-ever stroke, which constitutes three quarters of all stroke. In addition to population-wide prevention strategies (the mass' approach), the high risk' approach aims to identify individuals at risk of stroke and to modify their risk factors, and risk, accordingly. Current methods of assessing and modif

Treatment of the critically ill patient with protein C: Is it worth the cost?

INTRODUCTION: We have shown that low protein C levels predict poor survival up to five years in a general intensive care unit patient material and hypothesize that treatment with protein C is beneficial. The objectives were to calculate costs of protein C treatment, at best-case scenario, per statistical life saved. MATERIALS AND METHODS: Ninety-two patients with deranged global haemostatic tests

A Pilot Study Examining Associations between DYRK1A and alpha-Synuclein Dementias

Background: DYRK1A is a kinase targeting several proteins associated with the pathology of dementias, including alpha-synuclein and amyloid precursor protein. It is not clear if DYRK1A genetics are associated with neurodegenerative conditions. Objective: To determine if DYRK1A also has a genetic association with alpha-synuclein dementias such as dementia with Lewy bodies and Parkinson's disease de