Sökresultat

Finnish samples have been extensively utilized in studying single-gene disorders, where the founder effect has clearly aided in discovery, and more recently in genome-wide association studies of complex traits, where the founder effect has had less obvious impacts. As the field starts to explore rare variants' contribution to polygenic traits, it is of great importance to characterize and confirm

Peroxisome proliferator-activated receptor gamma (PPARG) is a master transcriptional regulator of adipocyte differentiation and a canonical target of antidiabetic thiazolidinedione medications. In rare families, loss-of-function (LOF) mutations in PPARG are known to cosegregate with lipodystrophy and insulin resistance; in the general population, the common P12A variant is associated with a decrea

Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,

Incorporating both ecosystem services and disservices into land-use decisions is essential for meeting conservation and livelihood goals. We discuss the merits and challenges of this concept, termed net effects, for birds in agroecosystems. Although birds have widely documented impacts on agriculture (e.g., pest control, crop damage), the net effects of such activities are rarely quantified. This

A search for vectorlike quarks is presented, which targets their decay into a Z boson and a third-generation Standard Model quark. In the case of a vectorlike quark T (B) with charge +2/3e (-1/3e), the decay searched for is T→Zt (B→Zb). Data for this analysis were taken during 2015 and 2016 with the ATLAS detector at the Large Hadron Collider and correspond to an integrated luminosity of 36.1 fb-1

With the ever-growing traffic demands, the transportation networks are getting more and more congested. While expanding these networks with more roads is both costly and in many cities not even feasible, the rapid development of new sensing and communication techniques has made it possible to perform control of transportation networks in real-time. With the right usage of such technologies, existi

Ion exchange membranes with high ionic contents typically suffer from excessive water uptake and dilution effects which compromise both mechanical properties and ion conductivity. In the present work we develop and compare partial quaternization, copolymerization and crosslinking as three different synthetic strategies to balance the ion exchange capacity (IEC), water uptake and hydroxide conducti

Micellisation of surfactants in deep eutectic solvents has been recently demonstrated to provide a controllable way to modify micelle morphology. Ion-pair interactions between the solvent and the surfactant headgroup were identified as affecting the micellisation by modifying the charge density of the micelle. Here we explore the micellisation of dodecylsulfate surfactants with different counterio

I mitt forskningsprojekt har jag studerat generna i ’the major histocompatibility complex’ (MHC). Generna i detta komplex kodar för molekyler som uttrycks på cellytan och dessa molekyler är avgörande för immunförsvarets förmåga att upptäcka och bekämpa patogener (sjukdomsalstrande mikroorganismer, som virus, bakterier och parasiter). Det övergripande syftet i min forskning har varit att undersöka Sex differences in immune responses have been observed across a wide range of animal species, with the generaltendency that males have weaker immune responses than females. These differences are at least partly caused by immune-regulating effects of sex hormones, and have been associated with an increased prevalence of autoimmune disorders in females and with a general tendency for males to be par

Osteoarthritis (OA) is a common chronic disease, causing joint pain and reduced physical function. OA progresses slowly over a period of several years; to avoid an exacerbation of symptoms, it is critical to able to diagnose the disease as early as possible. The identification of disease-specific biomarkers may enable such an early diagnosis. The aim of this study was to investigate potential biom

Public and private actors with critical roles for ensuring societal safety need to work proactively to reduce risks and vulnerabilities. Traditionally, risk management activities have often been performed in order to ensure continuous functioning of key societal services. Recently, however, business continuity management (BCM), and its analytical subcomponent business impact assessment (BIA), has

This paper employs an inductive case study to explore the relevance of the family functions in the opportunity creation process by immigrant entrepreneurs. We employ the perspective of the opportunity creation process and the family functions for theory building purposes. We conducted four cases of immigrant entrepreneurs who established businesses in Sweden and that have their origins in Lebanon

Small animals that winter at northern latitudes need to maximize energy intake and minimize energy loss. Many passerine birds use night-time hypothermia to conserve energy. A potential cost of night-time hypothermia with much theoretical (but little empirical) support is increased risk of night-time predation, due to reduced vigilance and lower escape speed in hypothermic birds. This idea has neve

Patient counseling on physical fitness remains underutilized in primary care, despite its clinical and cost effectiveness. Most counseling interventions have focused on aerobic activity and neglected another vital component of physical fitness, muscle strengthening, which has recently been shown to be independently protective against cardiometabolic diseases and premature mortality. This article r

Lytic polysaccharide monooxygenases (LPMOs) are copper-containing metalloenzymes that can cleave the glycosidic link in polysaccharides. This could become crucial for production of energy-efficient biofuels from recalcitrant polysaccharides. Although LPMOs are considered oxygenases, recent investigations have shown that H2O2 can also act as a co-substrate for LPMOs. Intriguingly, LPMOs generate H2

Cities are key actors in reducing both the causes of climate change (mitigation) and its impact (adaptation), and many have developed separate mitigation and adaptation strategies and measures. However, in order to maximize outcomes, both scholars and practitioners are increasingly calling for more integrated and synergetic approaches. Unfortunately, related research remains scarce and fragmented,

Trädgårdsboken om JORD ger svar på det mesta du behöver veta om jord i den egna trädgården. Vad är jord? Hur påverkar den oss och vår odling? Hur kan man förbättra, gödsla och underhålla olika sorters jord? Vilket förhållande har våra mest älskade växter till jorden? Jorden är nyckeln till allt. Sandlätt, torr och ljus eller mörk och en aning trött på hösten? Kunskap och omsorg om jorden är grun

Våra jordar är basen för en hållbar matproduktion. Vi har tagit jorden och jordarna för självklara men jordens hälsa är en garanti för framtiden. Jorden vi trampar på är av största vikt för allt levande på land. Med tanke på den alarmerande hastighet med vilken världens jordar håller på att förstöras är det viktigt att fästa uppmärksamheten på jord som en värdefull resurs som måste bevaras och utn