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Adenosine plays an important role in cell death and differentiation as well as in tumorigenesis and the intra- and extra-cellular levels range from nanomolar to millimolar levels under various physiological or pathophysiological conditions. Here we report that adenosine can activate HPV16 late gene expression in a dose- and time-dependent manner, but only in the presence of guanosine. This activat

Although a number of different medium access control (MAC) schemes are adopted for wireless multi-hop networks, time division multiple access (TDMA) approaches based on a periodic frame of time slots are the most common when very high efficiency is needed in terms of use of radio and energy resources. Efficient resource usage is typically based on parallel compatible transmissions from multiple no

Studies on the natural human exposures to fine particulate matter (PM2.5) and their elements composition are practically non-existent in South America. In order to understand the natural exposure of the typical Brazilian population to PM2.5 and their trace element composition, we measured PM2.5 concentrations and collected mass on filters for nine continuous hours during a typical workday of volun

Three new U–Pb ID-TIMS isotopic ages confirm previous evidence for two geochemically distinct, early Mesoproterozoic pulses of mafic magmatism along the western margin of Laurentia. The first is a U–Pb baddeleyite age of 1590 ± 5 Ma from a dyke swarm in the Tobacco Root Mountains of western Laurentia. It is the first evidence for magmatism of this age in west-central Laurentia. The second is a U–P

Artikeln är en komparativ studie av historieundervisning vid amerikanska och svenska lärosäten. Skillnaderna till trots märks vissa gemensamma drag såsom att styrmekanismerna har blivit allt fler, vilket har inneburit att den enskilde läraren har fått allt mindre att säga till om, bland annat till följd av en marknadsanpassning av högre utbildning med fokus på mätbarhet och utvärderingar. Samtidig

Investigating the chemical homogeneity of stars born from the same molecular cloud at virtually the same time is very important for our understanding of the chemical enrichment of the interstellar medium and with it the chemical evolution of the Galaxy. One major cause of inhomogeneities in the abundances of open clusters is stellar evolution of the cluster members. In this work, we investigate va

This paper focuses on entrepreneurship by academic leaders. With the use of patents, inventions, and spin-offs to measure commercialization, and directors, research group leaders, and business owners as academic leaders, results, using a sample of more than 2,500 German researchers, show differences across academic leaders and commercialization. Findings for spin-offs are different from those for

Begonia mariachristinae Wahlsteen, a new endemic species from Kachin, northern Myanmar, is described and illustrated. The new species is characterised by its combination of four perianth segments in the female flower, two ovary wings, two locules, two styles and a dioecious breeding system.

The breast cancer risk variants identified in genome-wide association studies explain only a small fraction of the familial relative risk, and the genes responsible for these associations remain largely unknown. To identify novel risk loci and likely causal genes, we performed a transcriptome-wide association study evaluating associations of genetically predicted gene expression with breast cancer

Laser-driven high-order harmonic generation1,2 provides spatially3 and temporally4 coherent tabletop sources of broadband extreme-ultraviolet (XUV) light. These sources typically operate at low repetition rates, frep ≲ 100 kHz, where phase-matched HHG is readily achieved5,6. However, many applications demand the improved counting statistics or frequency-comb precision afforded by high repetition r

Objective: We sought to examine changes in regional and sex disparities in stunting, thinness, and overweight among Chinese school-aged children from 1985 to 2014. Methods: We analyzed data on 1,489,953 children aged 7–18 years in the Chinese National Survey on Students’ Constitution and Health. Stunting, thinness, and overweight were defined according to WHO anthropomorphic definitions. After adj

Background: Malaria parasites and related haemosporidian parasites are widespread and may cause severe diseases in birds. These pathogens should be considered in projects aiming breeding of birds for purposes of sustained ex situ conservation. Cranes are the 'flagship species' for health assessment of wetland ecosystems, and the majority of species are endangered. Malaria parasites and other haemo

Dendritic cells (DC) are an integral part of the tumor microenvironment. Pancreatic cancer is characterized by reduced number and function of DCs, which impacts antigen presentation and contributes to immune tolerance. Recent data suggest that exosomes can mediate communication between pancreatic cancer cells and DCs. Furthermore, levels of DCs may serve as prognostic factors. There is also growin

While immunomodulatory monoclonal antibodies (mAbs) have therapeutic efficacy against many tumors, few patients are cured. Attempting to improve their therapeutic efficacy we have applied the TC1 mouse lung carcinoma model and injected established subcutaneous tumors intratumorally with 3 weekly doses of various combinations of mAbs. Combinations of mAbs to CTLA4/PD1/CD137 (the 3 mAb combination)

This study compares the historical evolution of Total Quality Management (TQM) to eight well-known management theories to investigate whether there are affinities between TQM and the selected management theories. The study uses the core values and components of the EFQM Excellence Model as the framework for the analysis which reveals that most of the ingredients in the selected management theories

In this reply to S. Durbin's comment on our original paper "Ultrafast terahertz-field-driven ionic response in ferroelectric BaTiO3," we concur that his final equations 8 and 9 more accurately describe the change in diffracted intensity as a function of Ti displacement. We also provide an alternative derivation based on an ensemble average over unit cells. The conclusions of the paper are unaffect

The purpose of this paper is to examine the hypothesis that increased participation in global value chains (GVCs), such as assembly of imported parts for exports, leads to higher economic growth. The focus is particularly on the extent to which this holds for low-income countries, and the role that capability-building, i.e. development of the national innovation system, plays in the possibility of

The local governments of EU member countries are attracted to the possibility of receiving EU funding. However, as the governance structures of EU funds are complex and dynamic, municipalities are increasingly drawing on the knowledge and resources of ‘EU experts’ who mediate and provide project support. This article contributes to our understanding of how EU cohesion policy is translated through

Purpose: There is a current trend in healthcare management away from produced and standardized one-size-fits-all processes toward co-created and individualized services. The purpose of this paper is to increase understanding of the value concept in healthcare organization and management by recognizing different levels of value (private, group and public) and the interconnectedness among these leve