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Law and Digital Society

The article argues that the digitally mediated and data-driven development stresses the need for socio-legal scrutiny. It focuses and briefly outline socio-legally relevant aspects of the “sharing” economy, that poses a number of conceptual issues on how we understand and regulate innovative platform based ventures. The article also underscores a number of issues relating to the role of consumer aIn this article we argue the need for more socio-legal scrutiny in a digitally mediated and data-driven development. We focus and briefly outline socio-legally relevant aspects of the “sharing” economy, that poses a number of conceptual issues on how we understand and regulate innovative platform based ventures. This also arguably underscores a number of issues relating to the role of consumer and

Clock-gating of streaming applications for energy efficient implementations on FPGAs

The paper investigates the reduction of dynamic power for streaming applications yielded by asynchronous dataflow designs by using clock gating techniques. Streaming applications constitute a very broad class of computing algorithms in areas such as signal processing, digital media coding, cryptography, video analytics, network routing and packet processing and many others. The paper introduces a

High-level synthesis of dynamic dataflow programs on heterogeneous MPSoC platforms

The growing complexity of digital signal processing applications make a compelling case the use of high-level design and synthesis methodologies for the implementation on programmable logic devices and embedded processors. Past research has shown that, for complex systems, raising the level of abstraction of design stages does not necessarily come at a penalty in terms of performance or resource r

Processes and actors: Translating Kahn processes to dataflow with firing

Dataflow programming is a paradigm for describing stream processing algorithms in a manner that naturally exposes their concurrency and makes the resulting programs readily implementable on highly parallel architectures. Dataflow programs are graph structured, with nodes representing computational kernels that process the data flowing over the edges. There are two major families of languages for t

Content-based caching in a managed runtime computing environment

A computer-implemented method of caching data in a managed runtime computing environment can include loading source data and comparing content of the source data with at least one of a plurality of cache entries. Each cache entry can include a representation of previously received source data and a transformation of the previously received source data. A transformation for the source data from a c

Neuron-enriched RNA-binding Proteins Regulate Pancreatic Beta Cell Function and Survival

Pancreatic beta cell failure is the central event leading to diabetes. Beta cells share many phenotypic traits with neurons, and proper beta cell function relies on the activation of several neuronal-like transcription programs. Regulation of gene expression by alternative splicing plays a pivotal role in brain, where it affects neuronal development, function and disease. The role of alternative s

Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS integrated care pathways (ICPs), (2) the joint initiative between the Reference site MACVIA-LR (Contre

Contextualizing distributed leadership in higher education

This case study of development in a technical university situates distributed leadership in higher education in an organizational perspective. Analysis of documentation from development programs and interviews with 10 faculty members showed that leadership practices were related to different institutional logics prominent in four key activities in this specific university: education, research, for

Paradiset. Ökenfädernas tänkespråk. Den systematiska samlingen VIII : Om att inte göra något för syns skull

Boken innehåller en grekisk text (baserad på cod. Athos Protaton 86) utgiven av Britt Dahlman och en svensk översättning av den systematiska samlingen av Apophthegmata Patrum (Ökenfädernas tänkespråk), bok 8. Översättningen har gjorts gemensamt av deltagarna i översättningsseminariet vid Johannesakademin.The book contains a Greek text (based on MS Athos Protaton 86) edited by Britt Dahlman and a Swedish translation of the Systematical collection of the Apophthegmata Patrum, book 8. The translation was made jointly by the participants in the translation seminar at Johannesakademin.

Lessons from basic pancreatic beta cell research in type-2 diabetes and vascular complications

The changes in life-style with increased access of food and reduced physical activity have resulted in the global epidemic of obesity. Consequently, individuals with type 2 diabetes and cardiovascular disease have also escalated. A central organ in the development of diabetes is the pancreas, and more specifically the pancreatic beta cells within the islets of Langerhans. Beta cells have been assi

Atmospheric mercury measurements onboard the CARIBIC passenger aircraft

Goal of the project CARIBIC (Civil Aircraft for the Regular Investigation of the atmosphere Based on an Instrumented Container) is to carry out regular and detailed observations of atmospheric composition (particles and gases) at cruising altitudes of passenger aircraft, i.e. at 9-12km. Mercury has been measured since May 2005 by a modified Tekran instrument (Tekran Model 2537 A analyser, Tekran I

Outset of the Morphology of Nanostructured Silica Particles during Nucleation Followed by Ultrasmall-Angle X-ray Scattering

Nucleation and growth of SBA-15 silica nanostructured particles with well-defined morphologies has been followed with time by small-angle X-ray scattering (SAXS) and ultrasmall-angle X-ray scattering (USAXS), using synchrotron radiation. Three different morphologies have been compared: platelets, toroids, and rods. SEM observations of the particles confirm that two key physical parameters control

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

Lenalidomide is a highly effective treatment for myelodysplastic syndrome (MDS) with deletion of chromosome 5q (del(5q)). Here, we demonstrate that lenalidomide induces the ubiquitination of casein kinase 1A1 (CK1α) by the E3 ubiquitin ligase CUL4-RBX1-DDB1-CRBN (known as CRL4CRBN), resulting in CK1α degradation. CK1α is encoded by a gene within the common deleted region for del(5q) MDS and haploi