Previous positron emission tomography (PET) studies have quantified filamentous tau pathology using regions-of-interest (ROIs) based on observations of the topographical distribution of neurofibrillary tangles in post-mortem tissue. However, such approaches may not take full advantage of information contained in neuroimaging data. The present study employs an unsupervised data-driven method to ide

Cadmium and lead have been classified as carcinogens by the International Agency for Research on Cancer. However, their associations with breast cancer risk are unknown despite their persistence in the environment and ubiquitous human exposure. We examined associations of circulating levels of cadmium and lead with breast cancer risk in three case–control studies nested within the Cancer Preventio

The Fluttering Shearwater (Puffinus gavia) is an abundant seabird endemic to breeding colonies in northern and central New Zealand. The species remains poorly studied, and here we present the first study to examine its breeding biology in detail. Fluttering Shearwater nests were monitored from laying in September to fledging in January 2016 on Burgess Island in the outer Hauraki Gulf, northern New

Common remediation and land management approaches often preclude economically attractive and low risk brownfield redevelopment. The authors argue that recently developed dynamic site characterization techniques can greatly improve sound decision making on land revitalization options. A number of these in-situ soil and groundwater test methods, such as MIP, ROST™/UVOST™, XRF and BAT, based on geote

In this article, numerical simulations have been conducted on the heat transfer effect of dimple/protrusion layouts of a pin-finned wedge duct. Conjugate heat transfer calculations are further performed to investigate the cooling effect of modified schemes with dimples and protrusions added. Comparisons are carried out with a turbine second stage guide vane employed as the prototype. The dimple/pr

In the field of exploration geophysics, the method known as "signal apparition" offers a different perspective on how to separate signals acquired from simultaneously fired seismic sources. The method uses a periodic sequence of small time shift variations to encode the different sources, and this choice leads to exact separation of signals in diamond-shaped regions of the frequencywavenumber doma

As almost all combustion processes of practical interest take place in the presence of turbulence, the development of the increasingly refined turbulence–chemistry interaction (TCI) models has led to highly sophisticated approaches. Nearly all of the studies comparing different models focus on stable premixed/non-premixed flame configurations. In this work, the focus is on well-documented, lean pr

The aim of this systematic review was to examine the associations between diabetic retinopathy (DR) and the common micro- and macrovascular complications of diabetes mellitus, and how these could potentially affect clinical practice. A structured search of the PubMed database identified studies of patients with diabetes that assessed the presence or development of DR in conjunction with other vasc

Although neutrophil extracellular traps (NETs) have been highlighted in several systemic inflammatory diseases, their clinical correlates and potential pathological role remain obscure. Herein, we describe a dramatic onset of systemic lupus erythematosus (SLE) with clear-cut pathogenic implications for neutrophils and NET formation in a young woman with cardiac (Libman–Sacks endocarditis) and cent

The Tröger’s base framework has been implemented in two different receptors. The first of these receptors,incorporating two 18-crown-6 moities, was used as a host in a binding study together with a sieries of bisammonium salts that yielded different binding constants that were then used as a benchmark to compare different computational methods (Molecular Mechanics (MM) and Density Functional TheorThe Tröger’s base framework has been implemented in two different receptors. The first of these receptors, incorporating two 18-crown-6 moities, was used as a host in a binding study together with a sieries of bisammonium salts that yielded different binding constants that were then used as a benchmark to compare different computational methods (Molecular Mechanics (MM) and Density Functional Theo

Internal combustion engines (ICE) have been a vital part of society ever since their inception more than a hundred years ago. While initially it seemed as if the replacement of horse and carriage had solved the issue with pollutant emissions, it became evident in the 60’s that emission from ICEs is a major concern. The first emissions in focus were the nitrogen oxides (NOx). Lately, however, focus

Background: Epidemiological studies suggest that haem iron, which is found predominantly in red meat and increases endogenous formation of carcinogenic N-nitroso compounds, may be positively associated with lung cancer. The objective was to examine the relationship between haem iron intake and lung cancer risk using detailed smoking history data and serum cotinine to control for potential confound

Because of the rarity of neuroblastoma and poor survival until the 1990s, information on late effects in neuroblastoma survivors is sparse. We comprehensively reviewed the long-term risk for somatic disease in neuroblastoma survivors. We identified 721 5-year survivors of neuroblastoma in Nordic population-based cancer registries and identified late effects in national hospital registries covering

Terrestrial Arctic ecosystems play a key role in the global carbon (C) cycle, as they store a large amount of organic matter in permafrost. Among regions with continuous permafrost, Svalbard has one of the warmest permafrost and may provide a template of the environmental responses of Arctic regions to future climate change. We analyze the CO2 fluxes at a polygonal tundra site in Adventdalen (Sval

Background: Physical activity reduces the risk of acquired cardiovascular disease, which is of great importance in patients with congenital heart disease (CHD). There are diverging data whether physical activity level (PAL) differs between patients with CHD and controls. Furthermore, it is unknown if PAL can be reliably assessed in patients with CHD using self-reported instruments. Methods: Sevent

Modification of the surface electronic properties of vertically aligned and randomly distributed carbon nanotubes and the hydrophobic character after exposure to Ar:F2 and CF4 plasma are exploited to optimize the sensing characteristics of these materials. The sensing properties of fluorinated carbon nanotubes are disclosed by probing their stability and responsiveness towards the detection of two

With older and aging populations, patients experience multiple chronic diseases at the same time. Individual chronic disease guidelines often recommend pharmacological therapies as a key intervention, resulting in patients being prescribed multiple regular medications for their different diseases. Although the term “polypharmacy” has been applied to the use of multiple medications, there is no con