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Acquired cystic fibrosis transmembrane regulator (CFTR) dysfunctions have been associated with several conditions, including myocardial infarction (MI). Here, CFTR is downregulated in brain, heart, and lung tissue and associates with inflammation and degenerative processes. Therapeutically increasing CFTR expression attenuates these effects. Whether potentiating CFTR function yields similar benefi

Detta är en bearbetad version på nederländska av min tidigare på svenska utgivna biografi om den engelske kungen Henrik VIII.De Zweedse hoogleraar Dick Harrison vertelt het kleurrijke levensverhaal van Hendrik VIII (1491-1547). Hendrik werd, na de dood van zijn vader, de tweede Tudor-koning van Engeland. Hij leidde een roemrucht bestaan. Hij had zes echtgenotes, van wie hij er twee liet onthoofden. Hij scheidde, voor eigen gewin, de Anglicaanse kerk af van de Kerk van Rome, en hij verenigde Engeland en Wales wettelijk i

Continuous evaluation of model results against observational data isvital to improving model projections of the structure and function offorest ecosystems. In this poster, we evaluate the forest management module of LPJ-GUESS (ver. 4. 1.2, rev 11016) across a latitudinal gradient in Sweden. The poster was presented at the LPJ-GUESS Community Meeting in Lund, May 3rd, 2023.

Denna avhandling belyser välbefinnandeprocesser utifrån två olika angreppssätt: 1)dels teoretiska beskrivningar av personligt växande, där personligt växandedefinieras som den gradvisa processen av förändring i välbefinnande, 2) delsempiriska undersökningar av välbefinnande och mental hälsa med fokus på eleversmentala hälsoprofiler och självuppfattning. Sammanlagt ingår fem studier iavhandlingen, This thesis follows two main lines of inquiry into well-being processes: 1) atheoretical exploration of personal growth, defined as the gradual growth of wellbeing, and 2) an empirical exploration of students’ mental health profiles and sense of self. Altogether five studies are included in the thesis, two of which follow thefirst line of inquiry (articles I and II) and three of which follow the s

Context: DevOps has recently become a mainstream solution for bridging the gaps between development (Dev) and operations (Ops) enabling cross-functional collaboration. The DevOps concept of continuous monitoring may bring a lot of benefits to development teams such as early detection of run-time errors and various performance anomalies. Objective: We aim to explore deep learning (DL) solutions for

BACKGROUNDThe evidence for temperature control for comatose survivors of cardiac arrest is inconclusive. Controversy exists as to whether the effects of hypothermia differ per the circumstances of the cardiac arrest or patient characteristics.METHODSAn individual patient data meta-analysis of the Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest (TTM) and Hypothermia versus

Recent assessments of the literature on the Haitian Revolution (1791–1804) offer radically different images, ranging from the identification of a politics of universal human rights to objections against conservative assumptions. The present article instead uncovers an overarching conflict between what is named the universality paradigm and the sceptical responses. However, in the outskirts of the

Open science and collaboration are necessary to facilitate the advancement of Parkinson’s disease (PD) research. Hackathons are collaborative events that bring together people with different skill sets and backgrounds to generate resources and creative solutions to problems. These events can be used as training and networking opportunities, thus we coordinated a virtual 3-day hackathon event, duri

BACKGROUND: Pain is a global health concern with substantial societal costs and limits the activity participation of individuals. The prevalence of pain is estimated to be high among individuals with cerebral palsy (CP).OBJECTIVES: To estimate the association between pain and labor outcomes for adults with CP in Sweden.METHODS: A longitudinal cohort study based on data from Swedish population-base

Aviation currently contributes about 3% of the world’s CO2 emissions, 5% of the global warming, and 35% of the trade. Reducing the emissions and the global warming from aviation is thus essential. Many approaches to achieve this goal are underway, including H2, fuel cells, and batteries, but also by replacing the fossil jet fuel with sustainable jet fuel from non-fossil feedstocks. This involves m

We examine whether exposure to gender inequality at export destinations affects the gender wage gap in exporting firms. We motivate the analysis through a stylized model where wages depend on worker productivity, and men have a comparative advantage when trading with gender-unequal countries due to customer discrimination. Empirically, we use high-quality matched employer-employee data from Sweden

Det finns runt 100 000 blinda och kraftigt synnedsatta individer (BKSI:er) i Sverige. Sådan synnedsättning leder till en kraftigt minskad förmåga för självständig förflyttning och lägre livskvalité, med ökad risk för arbetslöshet, trafikolyckor, en stillasittande livsstil och depression. Hälften av alla käpp- och hundanvändare är med om en huvudkollision årligen, och drygt var tredje för en fallolReduced independent mobility of blind and low-vision individuals (BLVIs) cause considerable societal cost, burden on relatives, and reduced quality of life for the individuals, including increased anxiety, depression symptoms, need of assistance, risk of falls, and mortality. Despite the numerous electronic travel aids proposed since at least the 1940’s, along with ever-advancing technology, the m

Studies have indicated that transportation noise is associated with higher cardiovascular mortality, whereas evidence of noise as a risk factor for respiratory and cancer mortality is scarce and inconclusive. Also, knowledge on effects of low-level noise on mortality is very limited. We aimed to investigate associations between road and railway noise and natural-cause and cause-specific mortality

BACKGROUND: Transportation noise increases the risk of ischemic heart disease (IHD), but few studies have investigated subtypes of IHD, such as myocardial infarction (MI), angina pectoris, or heart failure. We aimed to study whether exposure to road, railway and aircraft noise increased risk for ischemic heart disease (IHD), IHD subtypes, and heart failure in the entire adult Danish population, in

BACKGROUND: Epidemiologic studies have linked transportation noise to increased morbidity and mortality, particularly for cardiovascular outcomes. However, studies investigating metabolic outcomes such as diabetes are limited and have focused only on noise exposures estimated for the loudest residential façade.OBJECTIVES: We aimed to examine the influence of long-term residential exposure to trans

OBJECTIVES: To examine the role of prenatal and postnatal second-hand tobacco smoke (SHS) exposure on asthma, rhinitis, and eczema development up to 16 years of age.METHODS: A birth cohort of 4089 children was followed for 16 years. Information on parental smoking habits, lifestyle factors, and symptoms of allergic disease was gathered using repeated parental questionnaires. Generalized estimating

BACKGROUND: Epidemiological studies have linked transportation noise and cardiovascular diseases, however, atrial fibrillation (AF) has received limited attention. We aimed to investigate the association between transportation noise and AF risk.METHODS: Over the period 1990-2017 we estimated road and railway noise (Lden) at the most and least exposed façades for all residential addresses across De

PURPOSE: The Swedish Tattoo and Body Modifications Cohort (TABOO) cohort was established to provide an infrastructure for epidemiological studies researching the role of tattoos and other body modifications as risk factors for adverse health outcomes. It is the first population-based cohort with detailed exposure assessment of decorative, cosmetic, and medical tattoos, piercing, scarification, hen

OBJECTIVE: To investigate the association between long term residential exposure to road traffic and railway noise and risk of incident dementia.DESIGN: Nationwide prospective register based cohort study.SETTING: Denmark.PARTICIPANTS: 1 938 994 adults aged ≥60 years living in Denmark between 1 January 2004 and 31 December 2017.MAIN OUTCOME MEASURES: Incident cases of all cause dementia and dementi