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Acute myeloid leukemia is a genetically and cellularly heterogeneous disease. We characterize 120 AMLs using genomic and transcriptomic analyses, including single-cell RNA sequencing. Our results reveal an extensive cellular heterogeneity that distorts the bulk transcriptomic profiles. Selective examination of the transcriptional signatures of >90,000 immature AML cells identifies four main cluste
BackgroundDespite the high morbidity and severe consequences of epidermolysis bullosa (EB), current treatments remain inadequate, lacking efficacy and the ability to target the microbial and inflammatory components of EB wounds. In this first-in-human open-label, single-arm study—part 3 of a 3-part Phase 1 clinical trial—we examined the safety, tolerability, and systemic exposure of topically appl
INTRODUCTION: Survival and healthcare for patients with congenital heart disease have improved, and the number of pregnancies among women of childbearing age with congenital heart disease has increased. Our aim was to investigate obstetric outcomes in a large retrospective, national registry study of women with congenital heart disease compared to controls.MATERIAL AND METHODS: The study included
Entanglement is a key feature of quantum mechanics1–3, with applications in fields such as metrology, cryptography, quantum information and quantum computation4–8. It has been observed in a wide variety of systems and length scales, ranging from the microscopic9–13 to the macroscopic14–16. However, entanglement remains largely unexplored at the highest accessible energy scales. Here we report the
Det övergripande syftet med denna undersökning har varit att bredda bilden av Jon Fosse som dramatiker, genom att pröva hans pjäser mot ett perspektiv från den kritiska teorin – nämligen det utopiska, såsom det formulerats av Theodor W. Adorno och Ruth Levitas. Mer specifikt handlar det om att utforska negationen och dess utopiska potential i följande fem teaterstycken av Jon Fosse: Nokon kjem tilA general purpose of this study has been to refine the image of Jon Fosse as a playwright. The way to approach this has been to examine his plays from a perspective from critical theory – namely the utopian, as formulated by Theodor W. Adorno and Ruth Levitas. More specifically, the task has been to explore the negation and its utopian potential in the following five plays by Jon Fosse: Nokon kjem
Polyethylene glycol (PEG) is commonly used in the conservation of wooden artifacts, but its presence adversely affects the accuracy of radiocarbon dating. It is therefore critical to have robust methods for the removal of PEG from heritage materials. This paper presents the results of an experiment designed to test a protocol for the removal of low molecular-weight PEG-400 from conserved wood. We
BACKGROUND: Prediction models for sentinel lymph node (SLN) status could potentially substitute surgical axillary staging in patients with early breast cancer. Several imaging modalities have been used with various feature extraction and selection approaches. This systematic review and meta-analysis aimed to evaluate prediction models for SLN status based on breast imaging in patients with early b
Wood used in outdoor construction is consistently subjected to wetting by precipitation. High levels of moisture content, especially if sustained over long periods, promote fungal decay and structural degradation. Predicting temporal variation of moisture content in wood exposed to rain is essential for durability assessment, and simple fit-for-purpose numerical approaches have been developed for
Reusing building products is a feasible strategy for the construction and real estate industry to mitigate its climate impact. Sustainable reuse must be executed with quality assurance and defined responsibilities to encourage clients and avoid suboptimal outcomes. Despite the growing need to quality-assure reused products, there is limited research, particularly from an industry perspective. Prev
The 1914 eruption of Sakurajima (the Taisho eruption) caused catastrophic consequences by releasing enormous volcanic ash to Japan’s atmosphere, affecting both proximal and distal regions. As volcanic ash is a complex hazard that can cause damage to critical infrastructure and disrupt socio-economic activities, impacts from such an eruption in contemporary Japan will be more severe than in 1914. D
North Sea-Progressive Myoclonus Epilepsy (NS-PME) is a progressive neurological disorder, initially only associated with the homozygous GOSR2 founder mutation (c.430G>T; p.Gly144Trp). Clinical symptoms include untreatable early-onset ataxia, cortical myoclonus and epilepsy. Recently, the spectrum of GOSR2 mutations and associated phenotypic variability has expanded. To improve care and to facilita
This essay introduces four principles of nationalist historical narration by using the narrative strategies of the political parties the Sweden Democrats and the Danish People’s Party as examples. These narrative strategies follow the following four principles: 1. Nationalists cannot invent historical narratives solely out of figments of their imaginations. The Sweden Democrats, for example, can uThis essay introduces four principles of nationalist historical narration by using the narrative strategies of the political parties the Sweden Democrats and the Danish People’s Party as examples. These narrative strategies follow the following four principles: 1. Nationalists cannot invent historical narratives solely out of figments of their imaginations. The Sweden Democrats, for example, can u
Att läsa Mario Vargas Llosas Staden och hundarna är en utmaning för svenska universitetsstudenter som läser spanska som främmande språk, men trots detta visar kursutvärderingar att de tenderar att uppskatta upplevelsen. Denna studie fokuserar på att utforska studenternas läsprocess och deras reaktioner på texten genom ett läsloggprojekt. Felskis (2008) kategorier igenkänning, kunskap, förtrollningReading Mario Vargas Llosa's The time of the hero is a challenge for Swedish university students of Spanish as a foreign language, but despite this, course evaluations have shown that they tend to value the experience. This study focuses on exploring the students’ reading process and their reactions to the text through a reading log project. The categories of recognition, knowledge, enchantment an
BackgroundAmbulance clinicians regularly encounter medical, caring, existential and ethical challenges. Meeting patients with complex medical presentations underscore the need for holistic decision-making and actions as ambulance clinicians struggle to strike a balance between addressing medical and caring needs.AimThis study aimed to explore action alternatives considered and discussed during eth
Objective To evaluate any association of the presence and severity of nine major symptoms (pain, tiredness, drowsiness, nausea, appetite, breathlessness, depression, anxiety, and perceived well-being) with sleep quality and duration in elderly men.Design and setting Cross-sectional analysis within the population-based VAScular and Chronic Obstructive Lung disease study (VASCOL) conducted in southe
This study explored the international research collaboration led by China’s world-class universities and its impact during the first construction cycle of the “Double First-Class” initiative (2016–2020). We collected international collaborative publications based on the Scopus database and examined the performance of international research collaboration in terms of quantity, impact, collaborative
Contributing to analyses of housing welfare and inequality, this article examines how the territorial circumscription of asset-based welfare policies impact the pattern and trajectory of residential inequality in situ. We look to France, which since the 2000s has used asset-based welfare policies as a tool for rebalancing local territorial cohesion throughout the country. These policies, which onc
