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3s(2)3p-3s3p(2) transitions in SIV
We use both the civ3 and mchf codes to calculate oscillator strengths of allowed and intercombination lines in the 3s(2) 3p-3s3p(2) multiplets. Valence, core-valence and some core-core correlation effects are included. The two approaches give results in excellent agreement. Core effects are particularly important for the intercombination lines, though relatively minor for allowed transitions. We o
Acute allergic responses induce a prompt luminal entry of airway tissue eosinophils.
Traditionally, traffic and activation of eosinophils in asthmatic airways are thought to take place during the late-phase allergic reaction. The present study tests the hypothesis that when eosinophils are present in the tissue before allergen exposure, as in chronically inflamed asthmatic airways, acute anaphylactic reactions initiate an eosinophil response. Using a guinea-pig allergic model, whe
TOPICAL TACROLIMUS FOR THE TREATMENT OF ATOPIC DERMATITIS: A SYSTEMATIC REVIEW WITH META-ANALYSES
Wingless signaling in a large insect, the blowfly Lucilia sericata: A beautiful example of evolutionary developmental biology
Blowflies are the primary facultative agent in causing myiasis of domestic sheep in the whole world and, at the same time, it is an important tool for forensic medicine. Surprisingly, and in contrast to its importance, almost no data regarding the embryology and molecular markers are known for this insect. In this report, we present a detailed description of the blowfly Lucilia sericata embryogene
Reconstructing the pancreas: Restoration of normoglycemia, exocrine function, and islet innervation by islet transplantation to the pancreas
Impaired function in transplanted islets may be ascribed in part to disturbed reinnervation. The objectives of this study were to determine whether islet transplantation to the pancreas in the presence of nerve growth factor (NGF) would restore islet innervation and endocrine and exocrine pancreatic function. Streptozotocin-diabetic Lewis rats received 800 syngeneic islets beneath the pancreatic c
Structural insights into the active-ready form of [FeFe]-Hydrogenase and mechanistic details of its inhibition by carbon monoxide
[FeFe]-Hydrogenases harbor a {2Fe3S} assembly bearing two CO and two CN- groups, a mu-CO ligand, and a vacant coordination site trans to the mu-CO group. Recent theoretical results obtained studying the isolated {2Fe3S} subsite indicated that one of the CN- ligands can easily move from the crystallographic position to the coordination site trans to the mu-CO group; such an isomerization would have
A Monte Carlo investigation of dual-energy-window scatter correction for volume-of-interest quantification in 99Tcm SPECT
Using Monte Carlo simulation of 99Tcm single-photon-emission computed tomography (SPECT), we investigate the effects of tissue-background activity, tumour location, patient size, uncertainty of energy windows, and definition of tumour region on the accuracy of quantification. The dual-energy-window method of correction for Compton scattering is employed and the multiplier which yields correct acti
Increased circulating levels of proteinase 3 in patients with anti-neutrophilic cytoplasmic autoantibodies-associated systemic vasculitis in remission.
PRL signal transduction in the epithelial compartment of rat prostate maintained as long-term organ cultures in vitro
Using long-term organ cultures of rat prostate tissue explants, we previously demonstrated that PRL both stimulates proliferation and acts as an androgen-independent suppressor of apoptosis in prostate epithelial cells, leading to epithelial hyperplasia. In this work we delineate intracellular signaling molecules activated by PRL in prostate tissue to identify candidate signaling proteins that are
Secular Trends in Swedish Hip Fracture Incidence 1987-2002
Phenotypically different microalgal morphospecies with identical ribosomal DNA: A case of rapid adaptive evolution?
The agents driving the divergence and speciation of free-living microbial populations are still largely unknown. We investigated the dinoflagellate morphospecies Scrippsiella hangoei and Peridinium aciculiferum, which abound in the Baltic Sea and in northern temperate lakes, respectively. Electron microscopy analyses showed significant interspecific differences in the external cellular morphology,
Transition-state docking of flunitrazepam and progesterone in cytochrome P450
We have developed a method to dock a transition-state structure into the active site of an enzyme. Such an approach is more discriminative than standard docking when looking for substrates of an enzyme, because a transition state has more sterical restrictions than a nonreactive state. We use an accurate and tailored force field for the transition-state for the hydroxylation reaction in cytochrome
Hepatitis C virus RNA kinetics during the initial 12 weeks treatment with pegylated interferon-alpha 2a and ribavirin according to virological response
To optimize treatment of chronic hepatitis C early identification of patients who will not achieve a sustained virological response (SVR) is desirable. We investigated hepatitis C virus (HCV) RNA kinetics at day 1 (in 15 patients; genotypes 1 and non-1, 9 and 6 respectively) at weeks 1, 4 and 12 (in 53 patients; genotypes 1 and non-1, 19 and 34, respectively) during treatment with pegylated interf
Influence of mode of delivery on neonatal mortality and morbidity in spontaneous preterm breech delivery.
Objective: To study the association between mode of delivery and neonatal outcome in singleton pregnancy with breech presentation and preterm birth, due to premature tabour (PTL) and/or preterm premature rupture of the membranes (pPROM). Design and methods: Information on preterm (gestational week 25-36) singleton births in breech presentation in Sweden during 1990-2002 was obtained from the Swedi
The illness experiences of patients after a first time myocardial infarction
The purpose of this study was to investigate illness experiences of patients after a first myocardial infarction (MI), focusing on life situation and the recovery process over time. Thirty patients were interviewed within the first 3 days of hospitalisation, and again 17 weeks after discharge. The interviews were tape-recorded verbatim and the transcriptions were analysed and categorised using qua
Developing and testing a questionnaire to assess the quality of pain management in acute care in Sweden.
Pain management is an important indicator of the quality of patient care. The aim of this study was to develop and test a questionnaire to assess the quality of pain management in acute care in Sweden with emphasis on validity and reliability, as well as pain severity, interference with function, and patient participation. A descriptive cross-sectional study was conducted with consecutively select
Population genetic structure, gene flow and sex-biased dispersal in frillneck lizards (Chlamydosaurus kingii)
By using both mitochondrial and nuclear multiloci markers, we explored population genetic structure, gene flow and sex-specific dispersal of frillneck lizards (Chlamydosaurus kingii) sampled at three locations, separated by 10 to 50 km, in a homogenous savannah woodland in tropical Australia. Apart from a recombinant lizard, the mitochondrial analyses revealed two nonoverlapping haplotypes/populat
Low molecular weight heparin given the evening before surgery compared with conventional low-dose heparin in prevention of thrombosis
A prospective randomized double-blind trial was performed comparing conventional low-dose heparin with a low molecular weight heparin fragment for thromboprophylaxis in elective general abdominal surgical patients. The first dose of the heparin fragment was given the evening before surgery, and further doses were given thereafter every evening. There were 1002 analysable patients, 826 having recei
The tyranny of small steps: A reoccurring behaviour in management
The Tyranny of Small Steps (TYST) behaviour has been investigated. Explained through a systemic perspective, the behaviour TYST is an unwanted change to a system through a series of small activities that may be independent from one another. These activities are small enough not to be detected by the 'surveillance' within the system, but significant enough to encroach upon the 'tolerance zone' of t