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Structural characterization of protein-ligand binding interfaces at atomic resolution is essential for improving the design of specific and potent inhibitors. Herein, we explored fast 19F- and 1H-detected magic angle spinning NMR spectroscopy to investigate the interaction between two fluorinated ligand diastereomers with the microcrystalline galectin-3 carbohydrate recognition domain. The detaile

BACKGROUND: After combat-related lower extremity amputations, patients rapidly lose bone mineral density (BMD). As serial dual x-ray absorptiometry (DXA) scans are rarely performed in this setting, it is difficult to determine the timeline for bone loss and recovery or the role of interventions. However, a strong correlation has been demonstrated between DXA BMD and computed tomography (CT) signal

Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder characterized by brain aggregation of β-amyloid (Aβ) peptides and phosphorylated tau (P-tau) proteins. Extracellular vesicles (EVs) can be isolated and studied for potential roles in disease. While several studies have tested plasma-derived EVs in AD, few have analyzed EVs from cerebrospinal fluid (CSF), which are potentially mo

In this article, we argue for the relevance of studying the association between objects and people as co-constituting legality in everyday life rather than solely focusing either on people or on ‘icons’. Indeed, we go further and argue that scholarship is in danger of producing an impoverished version of legal consciousness if it fails to look beyond the human actors, the people in society. Studyi

The present article explores the implication of fairness as a regulatory and competition law concept applied to digital and Artificial Intelligence markets, in light of recent law and policy developments targeting the interaction between data, market power and competition law. Much of the policy discussions, legislative proposals as well some emerging case law elevate the matter of “fairness” in tThe present article explores the implication of fairness as a regulatory and competition law concept applied to digital and Artificial Intelligence markets, in light of recent law and policy developments targeting the interaction between data, market power and competition law.Much of the policy discussions, legislative proposals as well some emerging case law elevate the matter of “fairness” in th

Behrang Kianzad, researcher at Lund University School of Economics and Management, ponders the idea of fairness in EU regulation. It will be difficult to find someone who would argue in favour of a world that is unfair, yet the idea of fairness is not as universal as it may seem, nor is it easy to operationalise. The Commission attempts to do so in new regulation such as the DMA. Important questio

Importance: Large-scale estimates of bronchopulmonary dysplasia (BPD) are warranted for adequate prevention and treatment. However, systematic approaches to ascertain rates of BPD are lacking. Objective: To conduct a systematic review and meta-analysis to assess the prevalence of BPD in very low birth weight (≤ 1,500 g) or very low gestational age (< 32 weeks) neonates. Data sources: A search of M

Lake level, area and volume are sensitive indicators of climate change. At present, many studies have focused on the interannual water balance of lakes, but lake level and area can change remarkably with seasons, especially for lakes with seasonal ice cover. Zhari Namco, a seasonal frozen lake, was selected as an example to investigate its seasonal water balance. Multi-source altimetry and Landsat

Software analytics (SA) is frequently proposed as a tool to support practitioners in software engineering (SE) tasks. We have observed that several secondary studies on SA have been published. Some of these studies have overlapping aims and some have even been published in the same calendar year. This presents an opportunity to analyze the congruence or divergence of the conclusions in these studi

Van der Waals (vdW) magnetic materials are comprised of layers of atomically thin sheets, making them ideal platforms for studying magnetism at the two-dimensional (2D) limit. These materials are at the center of a host of novel types of experiments, however, there are notably few pathways to directly probe their magnetic structure. We confirm the magnetic order within a single crystal of NiPS3 an

The aim of this study was to give insights on the effects of an industrially relevant kilning method, with a focus on lipase inactivation and oat-base production. Storage of non-kilned, dehulled oat kernels in either room temperature or at 37 °C for up to 64 days led to increasing lipase activity with time, despite a decrease in moisture content and water activity, demonstrating the importance of

The use of deep learning for classification tasks has shown great potential in medical applications. In critical domains as such, it is of high interest to have trustworthy algorithms which are able to tell when a reliable assessment cannot be guaranteed. Hence, detecting out-of-distribution (OOD) samples is a crucial step towards building a safe classifier. Following a previous study, showing tha

Included in 'Peter Sheppard Skærved’s Knowledge Exchange Violin'. A project that brings together historic instruments, composers, nature , painting, ecologists, architecture, and much more.Krämarkapellet/The Chapel (US Premiere)The piece 'Eroded Memories of Heaven and Beyond' (inspired by Krämarkapellet in Petri Kyrka) was performed by Peter Sheppard Skærved, solo violin