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For many years, blood-based biomarkers for Alzheimer's disease seemed unattainable, but recent results have shown that they could become a reality. Convincing data generated with new high-sensitivity assays have emerged with remarkable consistency across different cohorts, but also independent of the precise analytical method used. Concentrations in blood of amyloid and phosphorylated tau proteins
Growing evidence supports the importance of lifestyle and environmental exposures— collectively referred to as the ‘exposome’—for ensuring immune health. In this narrative review, we summarize and discuss the effects of the different exposome components (physical activity, body weight management, diet, sun exposure, stress, sleep and circadian rhythms, pollution, smoking, and gut microbiome) on im
To explore the availability and accessibility of medically assisted reproduction (MAR) for people living with HIV in Europe, including the feasibility of cross-border care. Methods: We used a polymorphous engagement approach, primarily based on digital and email-based interviews with representatives of national HIV organizations, clinical researchers (infectious disease and/or infertility speciali
The concept of digital discretion has been defined as information and communication technology (ICT) influencing or replacing the professional judgment of civil servants. Studies within digital discretion has mainly taken a civil servants perspective focusing on how ICT can constrain or enable discretionary practices (Bovens and Zouridis 2002; Wenger and Wilkis 2009; Wihlborg et al. 2016) have inv
I have analyzed the coverage of the 30th anniversary of the Roundtable Agreement and June elections in Polish news-papers of all political hues. Additionally, I scrutinized several official speeches held in connection with the commemorations. The goal of my inquiry has been to examine the uses of memory of 1989 in Polish politics of 2019 and highlight the strategic choices and constraints faced by
The memory of the Holocaust has become one of the most salient and fully-fledged transnational collective memories traveling around the world. Most of the scholarship tracing the transnational flows of Holocaust memory representations has focussed on literature, films, and other media products. This lecture, however, instead foregrounds the research on memory practices in specific geographic locat
The article discusses the nationalist right-wing memory discourses in contemporary East Central and Southeastern Europe. It points out their main features such as: nationalization, re-nationalization, securitization, victimization, and weaponization of the Communist and post-Communist past. The focus is to explain the historical and cultural roots of these memory discourses, which are of vital imp
We tested concentration-dependence of selected gene transcripts (cat, gst, hsp70, hsp90, mt and sod) for evaluation as biomarkers of chemical stress. Contrary to the common approach of factorial designs and few exposure concentrations, we used regression across a high-resolution concentration series. Specifically, freshwater mussels (Anodonta anatina) were acutely (96 h) exposed to Cu (13 nominal
Context. Next to H and He, carbon is, together with oxygen, the most abundant element in the Universe and widely used when modelling the formation and evolution of galaxies and their stellar populations. For the Milky Way bulge, there are currently essentially no measurements of carbon in un-evolved stars, hampering our abilities to properly compare Galactic chemical evolution models to observatio
During solar storms, the Sun expels large amounts of energetic particles (SEP) that can react with the Earth’s atmospheric constituents and produce cosmogenic radionuclides such as 14C, 10Be and 36Cl. Here we present 10Be and 36Cl data measured in ice cores from Greenland and Antarctica. The data consistently show one of the largest 10Be and 36Cl production peaks detected so far, most likely produ
This paper presents experimental studies of the structures and burning velocities of premixed ammonia/air jet flames at high Karlovitz (Ka) number conditions. Simultaneous planar laser-induced fluorescence (PLIF) imaging of imidogen (NH) and hydroxyl (OH) radicals was performed to investigate the local flame structure and Laser Doppler Anemometry (LDA) measurements were employed for extracting com
Quantum computers based on rare-earth-ion-doped crystals show promising properties in terms of scalability and connectivity if single ions can be used as qubits. Through simulations, we investigate gate operations on such qubits. We discuss how gate and system parameters affect gate errors, the required frequency bandwidth per qubit, and the risk for instantaneous spectral diffusion (ISD). Further
As the lightest commercial metal structure material, magnesium alloy shows a wide application prospect in aerospace, automobile, 3C pro-ducts and other fields. At the same time, it is of great strategic significance to promote the application of magnesium alloy materials, in the face of the increasing shortage of iron and aluminum resources in the world and the dilemma of a large number of importe
Loess provides a valuable terrestrial record of past environmental conditions, including the dynamics and trajectories of air mass circulation responsible for dust transport. Here we explore variations in the luminescence sensitivity characteristics of sedimentary quartz and feldspar as possible tools for identifying changes in source down a loess-palaeosol sequence (LPS). Luminescence sensitivity
Increasing water deficits and severe droughts are expected to alter the dynamics of vegetation post-disturbance recovery by decreasing new recruitment and limiting growth in semi-arid Mediterranean ecosystems in future. However, which vegetation metrics will be shifted and how they respond over time are not clear, and the experimental evidence is still limited. Here we assessed the impacts of a lo
Sustainable low melting temperature bicomponent polyester fibers that can be circularly recycled were developed. The potentially biobased poly(hexamethylene terephthalate) (PHT), acting as the low melting temperature sheath material in the designed bicomponent fibers, was synthesized in a pilot scale. The obtained PHT with an intrinsic viscosity of 0.47 dL/g showed suitable processability when it
BACKGROUND: (Z,E)-9,12-tetradecadienyl acetate (ZETA, Z9,E12-14:OAc) is a major sex pheromone component for many stored-product moth species. This pheromone is used worldwide for mating disruption, detection, monitoring, and mass trapping in raw and processed food storage facilities. In this study, we demonstrate the biological production of ZETA pheromone by engineered yeast Saccharomyces cerevis
