PURPOSE: There is uncertainty whether ER-low tumors with a 1-10% immunohistochemical staining of nuclei represent a distinct molecular biological entity of BC, posing significant challenges for their clinical management and developing novel therapies. We aimed to elucidate ER-low tumor biology.EXPERIMENTAL DESIGN: We analyzed primary tumors included in a Swedish population-based SCAN-B BC cohort,

IntroductionNon-beta-haemolytic streptococci are among the most common causative agents of infective endocarditis (IE). Patients with a heart valve prosthesis (HVP) have a high risk of IE. We aimed to determine the risk for IE in patients with HVP and non-beta-haemolytic streptococcal bacteraemia (NBHSB), and to study NBHSB relapse depending on treatment duration.MethodAdults with HVP and NBHSB 20

BACKGROUND: Shock is common in intensive care units, and treatment includes fluids, vasopressor and/or inotropic drugs, guided by hemodynamic monitoring. The aim of this study was to identify current practice for treatment of shock in Scandinavian intensive care units.METHODS: Seven-day inception cohort study in 43 intensive care units in Scandinavia. Patients ≥ 15 years old receiving more than 4

BACKGROUND/AIMS: Ventricular-arterial coupling (VAC) plays a crucial role in cardiovascular physiology, affecting cardiac function and arterial properties for optimal organ perfusion. Considering that diabetes mellitus (DM) is a known risk factor for incident heart disease and vascular damage, this study aims to investigate whether changes in VAC due to DM occur earlier, even before the onset of c

Background/Objectives: There is a lack of research examining healthcare professionals' perspectives regarding the potential of non-pharmacological solutions such as immersive virtual reality (VR). The aim of this study was to investigate opportunities and challenges related to the application of immersive virtual reality (VR) technology in patients aged 65 and older undergoing surgery with regiona

Rationale: Early detection, standardized therapy, adequate infrastructure, and strategies for quality improvement should constitute essential components of every hospital’s sepsis plan. Objectives: To investigate the extent to which recommendations from the sepsis guidelines are implemented and the availability of infrastructure for the care of patients with sepsis in acute-care hospitals. Methods

INTRODUCTION: The primary objective was to map the impact on confidence and performance on radiographic examinations among undergraduate radiography students utilizing virtual reality (VR). The secondary objective was to identify potential pitfalls to avoid in future VR implementation.METHODS: A systematic review was conducted, which included comprehensive search in nine databases. The software Co

This chapter explores how the poorest of the poor made a living in 1740 Stockholm. The 1740 mantalslängd, a sort of proto-census, describes the work done by the entirety of Stockholm's inhabitants in unusual detail, preserving information about beggars, street-peddlers, and both formal and informal poor-relief.

Av de tusentals stjärnor som analyserats i detta arbete framträder stjärnan Gliese 710 som särskilt intressant. Denna stjärna förväntas passera solen på ett avstånd av ungefär 10000 gånger avståndet mellan jorden och solen, om cirka 1.3 miljoner år. Även om detta låter avlägset kan en sådan förbiflygning störa det avlägsna Oort-molnet som omger solsystemet, vilket potentiellt kan öka antalet kometClose stellar encounters play a critical role in shaping planetary systems by perturbing the orbits of minor body populations like the Oort Cloud and the orbits of planets. Using data from the Gaia DR3 catalogue, this work quantifies close stellar encounters, investigating both Sun-star and star-star interactions. Assuming that stars move in straight lines, encounter distances and times were com

The replacement of fossil fuels by intermittent renewable energy sources is transforming energy systems world-wide. A significant part of the future electricity demand will be supplied by offshore renewable energy, especially wind, but emerging technologies such as wave and tidal energy also offer great potential. However, the ability of offshore renewable energy systems – and of power systems and

This paper introduces a new framework – RoadRAT - to calculate the probability of inundation, wave runup, and storm erosion impacting coastal roads. Extreme value analysis is applied to annual maxima of observed and simulated still water level levels (SWL), total water levels (SWL + runup), and storm erosion volumes. The probability of impact on the road is derived both for the present conditions

With increased focus on sustainable building materials and the growing popularity of uncoated wooden cladding, understanding consumer acceptance of aesthetic changes becomes crucial for sustainable architectural choices. This study investigated consumer acceptance of uncoated wooden cladding in Norway, Sweden, and Germany, focusing on personality traits and perceptions. Using an online survey with

In this article I first follow Aristotle's and Plato's critique of materialism in an ancient context, then, in order to bring the topic into a more modern discussion, I follow Marx' dissertation on Democritos and Epicurus in its attempts to counter this critique from a materialist standpoint. Finally I conclude in reaffirming and nuancing Aristotle's critique, showing the limits of using matter as

Denna studie undersöker hur restid upplevs och används av kollektivtrafikresenärer. Genom en enkät med drygt tusen respondenter och samtal i en fokusgrupp framkommer flera intressanta insikter.Mobiltelefonen har blivit den mest använda utrustningen ombord, medan traditionella medier som böcker och tidningar har minskat i förekomst. Vanliga aktiviteter under resan inkluderar att scrolla på mobilen,This study examines how travel time is perceived and utilised by public transport passengers. Through a survey of just over a thousand respondents and discussions in a focus group, several interesting insights emerge.The mobile phone has become the most used device on board, while traditional media such as books and newspapers have decreased in prevalence. Common activities during the journey incl

Collaboration in governing complex environmental challenges is the norm. However, collaboration does not necessarily deliver desirable outcomes, and the importance of forming collaborative networks that effectively address the challenges at hand has been emphasized in theory and practice. Evidence for what constitutes a suitable network structure is still scarce, and the understanding of what fact

Absolute environmental sustainability assessments quantify the environmental impacts of human activities in relation to ecological carrying capacities. Such assessments necessitate the application of sharing principles to allocate shares of carrying capacity to actors and activities at different scales, including products, companies, sectors, and countries. This can help decision-makers set target