In this work we measured, by using a direct approach, the equilibrium solubility of recombinant Aβ40 peptide to be S ​= ​0.36 ​± ​0.15 ​μM in aqueous solution of 20 ​mM sodium phosphate buffer at pH 7.4. Microfluidic diffusional sizing (MDS) and mass spectrometry (MALDI-TOF/TOF) with isotope standard were used to quantify the concentration of soluble Aβ40 species coexisting with formed fibrils. A

Elevated maternal glucocorticoid levels during gestation can lead to phenotypic changes in offspring via maternal effects. Although such effects have traditionally been considered maladaptive, maternally derived glucocorticoids may adaptively prepare offspring for their future environment depending upon the correlation between maternal and offspring environments. Nevertheless, relatively few studi

Data generated over nearly two decades clearly demonstrate the importance of epigenetic modifications and mechanisms in the pathogenesis of type 2 diabetes. However, the role of pharmacoepigenetics in type 2 diabetes is less well established. The field of pharmacoepigenetics covers epigenetic biomarkers that predict response to therapy, therapy-induced epigenetic alterations as well as epigenetic

Body mass is a commonly used indicator of the energy stores of migratory animals and there is considerable evidence that it is a critical determinant of migration decisions and outcomes. Mean population mass often increases during the post-breeding period in most migratory species. Usually, this increase is interpreted as the result of fuel accumulation for migration based on the assumption that m

Global shifts in technology and demand patterns might necessitate a firm’s switching to another inventory management system. The following five popular types of inventory policies are compared in terms of their impact on relevant inventory costs and bullwhip effect: newsvendor, order-up-to, min-max, reorder-point order-quantity, and economic order quantity. The model of four-stage supply chain pre

The Covid-19 pandemic represented a crisis that was handled in very different ways by different retailers. The purpose of this comprehensive empirical study is to explore how Swedish retailers adapted their retail formats, activities and governance over the course of the pandemic. Three types of adaptations were observed: adaptations in the physical store environment, new services connected to the

We construct a 2-generated pro-2 group with full normal Hausdorff spectrum [0, 1] [0,1], with respect to each of the four standard filtration series: the 2-power series, the lower 2-series, the Frattini series, and the dimension subgroup series. This answers a question of Klopsch and the second author, for the even prime case; the odd prime case was settled by the first author and Klopsch. Also, o

Coronavirus disease 2019 (COVID-19) has caused global disruption and a significant loss of life. Existing treatments that can be repurposed as prophylactic and therapeutic agents may reduce the pandemic’s devastation. Emerging evidence of potential applications in other therapeutic contexts has led to the investigation of dietary supplements and nutraceuticals for COVID-19. Such products include v

Free electron lasers or FELs, have transformed the way science has been done in the last decades by providing coherent, highly brilliant radiation at wavelengths not achievable with conventional lasers. Their most important characteristic, along side brightness, is their coherence, which allows users to perform experiments that rely on precise phase characteristics of the probing radiation.The FEL

The advent of x-ray free-electron lasers (FELs) drastically enhanced the capabilities of several analytical techniques, for which the degree of transverse (spatial) coherence of the source is essential. FELs can be operated in self-amplified spontaneous emission (SASE) or seeded configurations, which rely on a qualitatively different initialization of the amplification process leading to light emi

Purification of biopharmaceuticals has shifted toward continuous and integrated processes, in turn bringing along a need for monitoring and control to maintain a desired separation between the target pharmaceutical and any impurities it may carry. In this study, a cycle-to-cycle control of the retention volumes of two compounds in a chromatographic, ion exchange purification step was developed, al

Kort efter att hon bevittnat den franska revolutionens fasor i Paris reste den engelska filosofen och feministen Mary Wollstonecraft till ett sömnigt Skandinavien. Kontrasterna kunde inte ha varit större. Ändå var det just i Sverige som hennes sista, stora politiska fråga väcktes: Hur förändrar man ett samhälle? Lena Halldenius följer Wollstonecraft på hennes sista filosofiska resa.Bildningsboxen

Background: The pathogenesis of appendicitis is not understood completely and establishing a correct diagnosis can be clinically challenging. Previous investigations have shown an association between a T helper cell (Th)2-mediated inflammatory response, for example immunoglobulin E (IgE)-mediated allergy, and a decreased risk of complicated appendicitis. The present study aimed to evaluate differe

The majority of studies on internal brand equity examine its various dimensions and relationships between them. While prior research specifies organizational practices relevant for successful internal branding, the insights about the impact of essential organizational factors on internal brand equity are still limited. This study focuses on organizational resilience that is vital for the existenceThe majority of studies on internal brand equity examine its various dimensions and relationships between them. While prior research specifes organizational practices relevant for successful internal branding, the insights about the impact of essential organizational factors on internal brand equity are still limited. This study focuses on organizational resilience that is vital for the existence

Winter warming events (WWE) are abrupt and short-lasting (hours-to-days) events of extraordinarily warm weather occurring during wintertime, sometimes accompanied by rainfall (rain on snow events; ROS). Through direct heat transfer and changes in the snowpack properties, these events cause changes in the below-ground thermal regime that, in turn, controls a suite of ecosystem processes ranging fro

Ambitiösa ideal om tvärvetenskap är välkänt svåra att omsätta i praktiken, delvis beroende på att de motarbetas av hur många universitet är strukturerade. Detta är ett problem för doktorander i tvärvetenskapliga projekt såväl som för deras handledare. Tvärvetenskapliga doktorander har precis som alla doktorander ett forskningsämne i vilket de förväntas utvecklas till självständiga forskare men ockAmbitious ideals about interdisciplinarity are notoriously difficult to put into practice, partly because they are counteracted by how many universities are organised. This is a problem for doctoral students in interdisciplinary projects as well as for their supervisors. Interdisciplinary doctoral students, like all doctoral students, have a research subject in which they are expected to develop i

The theoretical foundation of inflation targeting was laid out by the Swedish economist Knut Wicksell (1851-1926) in his groundbreaking treatise, Interest and Prices, published originally in German in 1898. Here he proposed price stability as the rule for monetary policy. Today, inflation targeting is considered the best-practice approach to monetary policy across the world. It has contributed to

A piece about a just transition to a low-carbon future (contribution to UNESCO Inclusive Policy Lab 'Think pieces' that explores emerging issues in inclusive policies as well as offering cutting edge solutions).