Understanding the complete immune cell composition of human neuroblastoma (NB) is crucial for the development of immunotherapeutics. Here, we perform single-cell RNA sequencing (scRNA-seq) on 19 human NB samples coupled with multiplex immunohistochemistry, survival analysis, and comparison with normal fetal adrenal gland data. We provide a comprehensive immune cell landscape and characterize cell-

Coal is used to generate electricity and produce high-value chemicals through coal gasification, liquefaction, and coke. During combustion sulfur is released, which leads to acid rain formation. Mineral matter present in coal is undesirable because it causes technological problems such as corrosion of equipment and reduction of overall rate of combustion of coal. Also, after combustion, the minera

Aim of the studyRates of bystander CPR are increasing, yet mortality after out-of-hospital cardiac arrest (OHCA) remains high. The aim of this survey was to explore public knowledge and attitudes to CPR. Our hypotheses were that recent CPR training (< 5 years) would be associated with a high-quality response in a case vignette of OHCA with agonal breathing, and associated with an interest to becom

AimTo analyze the impact of a time-gain selective, first-responder dispatch system on the presence of a shockable initial rhythm (SIR), return of spontaneous circulation (ROSC) and 30-day survival after out-of-hospital cardiac arrest (OHCA).MethodA retrospective observational study comprising OHCA registry data and dispatch data in the Skåne Region, Sweden (2010–2018). Data were categorized accord

Långt innan poesin blev kärlekens språk var den maktens och hatets tjänare. Än idag är den ett effektivt vapen i kampen om makt och inflytande. I "Poesi som propaganda" berättar propagandaforskaren Jimmy Vulovic om hur och varför dikten så ofta har tvingats tjäna maktens intressen. Med tematiska nedslag i härskarhymner samt krigs-, seger- och gudsdikter tecknas propagandapoesins historia från kils

Ligaments of the knee provide stability and prevent excessive motions of the joint. Rupture of the anterior cruciate ligament (ACL), a common sports injury, results in an altered loading environment for other tissues in the joint, likely leading to their mechanical adaptation. In the collateral ligaments, the patterns and mechanisms of biomechanical adaptation following ACL transection (ACLT) rema

Digital platforms are spreading very fast and new opportunities are emerging in the realm of digital services. But, can any firm easily succeed with a new platform business model? Well, reality seems to be quite complex. Focusing on digital health platforms as examples of new business models in highly regulated sectors, we outline the challenges that platforms should prepare for.

Civil society leadership training programmes are a new phenomenon, and they are often overlooked by civil society scholarship despite being linked to the professionalisation of the sector. In this article, we examine 14 Swedish leadership programmes in order to identify leadership ideals in the sector. Drawing on the notion of ‘symbolic boundaries’, we argue that leadership programmes produce hori

Nordic welfare states continue to rely on strong central and local governments in the regulation, funding, and implementation of social policies. However, decentralization of particular policy areas (e.g. activation policies) have further increased the significance of the local level in Nordic social policy regulation. However, increasing differences between local entities (e.g. between urban and

Sepsis is caused by systemic infection and is a major health concern as it is the primary cause of death from infection. It is the leading cause of mortality worldwide and there are no specific effective treatments for sepsis. Gene deletion of the neutral solute channel Aquaporin 9 (AQP9) normalizes oxidative stress and improves survival in a bacterial endotoxin induced mouse model of sepsis. In t

Osteoporotic fractures are one of the major problems facing healthcare systems worldwide. Undoubtedly, fragility fractures of the hip represent a far greater burden in terms of morbidity, mortality, and healthcare costs than other fracture sites. However, despite the significant impact on the health and quality of life of older adults, there is a general lack of awareness of osteoporosis, which re

Aims: Repeated risk assessments and treatment patterns over long time are sparsely studied in chronic thromboembolic pulmonary hypertension (CTEPH); thus, we aimed to investigate changes in risk status and treatment patterns in incident patients with CTEPH over a 5 year period. Methods and results: Descriptive and explorative study including 311 patients diagnosed with CTEPH 2008–2019 from the Swe